Targeting the intestinal L-cell for obesity and type 2 diabetes treatment

TY - JOUR

T1 - Targeting the intestinal L-cell for obesity and type 2 diabetes treatment

AU - Albrechtsen, Nicolai Jacob Wewer

AU - Kuhre, Rune Ehrenreich

AU - Deacon, Carolyn F.

AU - Holst, Jens Juul

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Degradation-resistant glucagon-like peptide-1 (GLP-1) mimetics and GLP-1 enhancers (inhibitors of dipeptidyl peptidase-4, the enzyme which degrades and inactivates GLP-1) have been used for treatment of type 2 diabetes mellitus since 2005-2006. Cutting-edge research is now focusing on uncovering the secretory mechanisms of the GLP-1-producing cells (L-cells) with the purpose of developing agonists that enhance endogenous hormone secretion. Since GLP-1 co-localizes with other anorectic peptides, cholecystokinin, oxyntomodulin/glicentin and peptide YY, L-cell targeting might cause release of several hormones at the same time, providing additive effects on appetite and glucose regulation. In this review, we explore the role of proglucagon-derived peptides and other L-cell co-localizing hormones, in appetite regulation and the mechanism regulating their secretion.

AB - Degradation-resistant glucagon-like peptide-1 (GLP-1) mimetics and GLP-1 enhancers (inhibitors of dipeptidyl peptidase-4, the enzyme which degrades and inactivates GLP-1) have been used for treatment of type 2 diabetes mellitus since 2005-2006. Cutting-edge research is now focusing on uncovering the secretory mechanisms of the GLP-1-producing cells (L-cells) with the purpose of developing agonists that enhance endogenous hormone secretion. Since GLP-1 co-localizes with other anorectic peptides, cholecystokinin, oxyntomodulin/glicentin and peptide YY, L-cell targeting might cause release of several hormones at the same time, providing additive effects on appetite and glucose regulation. In this review, we explore the role of proglucagon-derived peptides and other L-cell co-localizing hormones, in appetite regulation and the mechanism regulating their secretion.

KW - appetite regulation

KW - gut hormones

KW - gut-brain axis

KW - L-cell

KW - obesity

U2 - 10.1586/17446651.2014.862152

DO - 10.1586/17446651.2014.862152

M3 - Journal article

AN - SCOPUS:84893138518

SN - 1744-6651

VL - 9

SP - 61

EP - 72

JO - Expert Review of Endocrinology & Metabolism

JF - Expert Review of Endocrinology & Metabolism

IS - 1

ER -