Skeletal (stromal) stem cells: An update on intracellular signaling pathways controlling osteoblast differentiation

Basem M Abdallah; Abbas Jafari Kermani; Walid Zaher; Weimin Qiu; Moustapha Kassem

doi:10.1016/j.bone.2014.07.028

Skeletal (stromal) stem cells: An update on intracellular signaling pathways controlling osteoblast differentiation

Basem M Abdallah, Abbas Jafari Kermani, Walid Zaher, Weimin Qiu, Moustapha Kassem

66 Citations (Scopus)

Abstract

Skeletal (marrow stromal) stem cells (BMSCs) are a group of multipotent cells that reside in the bone marrow stroma and can differentiate into osteoblasts, chondrocytes and adipocytes. Studying signaling pathways that regulate BMSC differentiation into osteoblastic cells is a strategy for identifying druggable targets for enhancing bone formation. This review will discuss the functions and the molecular mechanisms of action on osteoblast differentiation and bone formation; of a number of recently identified regulatory molecules: the non-canonical Notch signaling molecule Delta-like 1/preadipocyte factor 1 (Dlk1/Pref-1), the Wnt co-receptor Lrp5 and intracellular kinases. This article is part of a Special Issue entitled: Stem Cells and Bone.

Original language	English
Journal	Bone
Volume	70
Pages (from-to)	28-36
Number of pages	9
ISSN	8756-3282
DOIs	https://doi.org/10.1016/j.bone.2014.07.028
Publication status	Published - 1 Jan 2015

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title = "Skeletal (stromal) stem cells: An update on intracellular signaling pathways controlling osteoblast differentiation",

abstract = "Skeletal (marrow stromal) stem cells (BMSCs) are a group of multipotent cells that reside in the bone marrow stroma and can differentiate into osteoblasts, chondrocytes and adipocytes. Studying signaling pathways that regulate BMSC differentiation into osteoblastic cells is a strategy for identifying druggable targets for enhancing bone formation. This review will discuss the functions and the molecular mechanisms of action on osteoblast differentiation and bone formation; of a number of recently identified regulatory molecules: the non-canonical Notch signaling molecule Delta-like 1/preadipocyte factor 1 (Dlk1/Pref-1), the Wnt co-receptor Lrp5 and intracellular kinases. This article is part of a Special Issue entitled: Stem Cells and Bone.",

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AU - Zaher, Walid

AU - Qiu, Weimin

AU - Kassem, Moustapha

PY - 2015/1/1

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AB - Skeletal (marrow stromal) stem cells (BMSCs) are a group of multipotent cells that reside in the bone marrow stroma and can differentiate into osteoblasts, chondrocytes and adipocytes. Studying signaling pathways that regulate BMSC differentiation into osteoblastic cells is a strategy for identifying druggable targets for enhancing bone formation. This review will discuss the functions and the molecular mechanisms of action on osteoblast differentiation and bone formation; of a number of recently identified regulatory molecules: the non-canonical Notch signaling molecule Delta-like 1/preadipocyte factor 1 (Dlk1/Pref-1), the Wnt co-receptor Lrp5 and intracellular kinases. This article is part of a Special Issue entitled: Stem Cells and Bone.

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JF - Bone

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Skeletal (stromal) stem cells: An update on intracellular signaling pathways controlling osteoblast differentiation

Abstract

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