Skeletal (stromal) stem cells: An update on intracellular signaling pathways controlling osteoblast differentiation

TY - JOUR

T1 - Skeletal (stromal) stem cells

T2 - An update on intracellular signaling pathways controlling osteoblast differentiation

AU - Abdallah, Basem M

AU - Kermani, Abbas Jafari

AU - Zaher, Walid

AU - Qiu, Weimin

AU - Kassem, Moustapha

N1 - Copyright © 2014 Elsevier Inc. All rights reserved.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Skeletal (marrow stromal) stem cells (BMSCs) are a group of multipotent cells that reside in the bone marrow stroma and can differentiate into osteoblasts, chondrocytes and adipocytes. Studying signaling pathways that regulate BMSC differentiation into osteoblastic cells is a strategy for identifying druggable targets for enhancing bone formation. This review will discuss the functions and the molecular mechanisms of action on osteoblast differentiation and bone formation; of a number of recently identified regulatory molecules: the non-canonical Notch signaling molecule Delta-like 1/preadipocyte factor 1 (Dlk1/Pref-1), the Wnt co-receptor Lrp5 and intracellular kinases. This article is part of a Special Issue entitled: Stem Cells and Bone.

AB - Skeletal (marrow stromal) stem cells (BMSCs) are a group of multipotent cells that reside in the bone marrow stroma and can differentiate into osteoblasts, chondrocytes and adipocytes. Studying signaling pathways that regulate BMSC differentiation into osteoblastic cells is a strategy for identifying druggable targets for enhancing bone formation. This review will discuss the functions and the molecular mechanisms of action on osteoblast differentiation and bone formation; of a number of recently identified regulatory molecules: the non-canonical Notch signaling molecule Delta-like 1/preadipocyte factor 1 (Dlk1/Pref-1), the Wnt co-receptor Lrp5 and intracellular kinases. This article is part of a Special Issue entitled: Stem Cells and Bone.

U2 - 10.1016/j.bone.2014.07.028

DO - 10.1016/j.bone.2014.07.028

M3 - Journal article

C2 - 25138551

SN - 8756-3282

VL - 70

SP - 28

EP - 36

JO - Bone

JF - Bone

ER -