Physical mapping and cloning of RAD56

David P Mathiasen; Irene Gallina; Susanne Manuela Germann; Wissam Hamou; Morgane Eléouët; Sara Thodberg; Nadine Eckert-Boulet; John Game; Michael Lisby

doi:10.1016/j.gene.2013.01.044

Physical mapping and cloning of RAD56

David P Mathiasen, Irene Gallina, Susanne Manuela Germann, Wissam Hamou, Morgane Eléouët, Sara Thodberg, Nadine Eckert-Boulet, John Game, Michael Lisby

Abstract

Here we report the physical mapping of the rad56-1 mutation to the NAT3 gene, which encodes the catalytic subunit of the NatB N-terminal acetyltransferase in Saccharomyces cerevisiae. Mutation of RAD56 causes sensitivity to X-rays, methyl methanesulfonate, zeocin, camptothecin and hydroxyurea, but not to UV light, suggesting that N-terminal acetylation of specific DNA repair proteins is important for efficient DNA repair.

Translated title of the contribution	Fysisk kortlægning og klonering af RAD56
Original language	English
Journal	Gene
Volume	519
Issue number	1
Pages (from-to)	182-186
Number of pages	5
ISSN	0378-1119
DOIs	https://doi.org/10.1016/j.gene.2013.01.044
Publication status	Published - 25 Apr 2013

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http://www.sciencedirect.com/science/article/pii/S0378111913001170

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title = "Physical mapping and cloning of RAD56",

abstract = "Here we report the physical mapping of the rad56-1 mutation to the NAT3 gene, which encodes the catalytic subunit of the NatB N-terminal acetyltransferase in Saccharomyces cerevisiae. Mutation of RAD56 causes sensitivity to X-rays, methyl methanesulfonate, zeocin, camptothecin and hydroxyurea, but not to UV light, suggesting that N-terminal acetylation of specific DNA repair proteins is important for efficient DNA repair.",

author = "Mathiasen, {David P} and Irene Gallina and Germann, {Susanne Manuela} and Wissam Hamou and Morgane El{\'e}ou{\"e}t and Sara Thodberg and Nadine Eckert-Boulet and John Game and Michael Lisby",

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T1 - Physical mapping and cloning of RAD56

AU - Mathiasen, David P

AU - Gallina, Irene

AU - Germann, Susanne Manuela

AU - Hamou, Wissam

AU - Eléouët, Morgane

AU - Thodberg, Sara

AU - Eckert-Boulet, Nadine

AU - Game, John

AU - Lisby, Michael

PY - 2013/4/25

Y1 - 2013/4/25

N2 - Here we report the physical mapping of the rad56-1 mutation to the NAT3 gene, which encodes the catalytic subunit of the NatB N-terminal acetyltransferase in Saccharomyces cerevisiae. Mutation of RAD56 causes sensitivity to X-rays, methyl methanesulfonate, zeocin, camptothecin and hydroxyurea, but not to UV light, suggesting that N-terminal acetylation of specific DNA repair proteins is important for efficient DNA repair.

AB - Here we report the physical mapping of the rad56-1 mutation to the NAT3 gene, which encodes the catalytic subunit of the NatB N-terminal acetyltransferase in Saccharomyces cerevisiae. Mutation of RAD56 causes sensitivity to X-rays, methyl methanesulfonate, zeocin, camptothecin and hydroxyurea, but not to UV light, suggesting that N-terminal acetylation of specific DNA repair proteins is important for efficient DNA repair.

U2 - 10.1016/j.gene.2013.01.044

DO - 10.1016/j.gene.2013.01.044

M3 - Journal article

C2 - 23403232

SN - 0378-1119

VL - 519

SP - 182

EP - 186

JO - Gene

JF - Gene

IS - 1

ER -

Physical mapping and cloning of RAD56

Abstract

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