Physical mapping and cloning of RAD56

David P Mathiasen; Irene Gallina; Susanne Manuela Germann; Wissam Hamou; Morgane Eléouët; Sara Thodberg; Nadine Eckert-Boulet; John Game; Michael Lisby

doi:10.1016/j.gene.2013.01.044

Physical mapping and cloning of RAD56

Bidragets oversatte titel: Fysisk kortlægning og klonering af RAD56

David P Mathiasen, Irene Gallina, Susanne Manuela Germann, Wissam Hamou, Morgane Eléouët, Sara Thodberg, Nadine Eckert-Boulet, John Game, Michael Lisby

Abstract

Here we report the physical mapping of the rad56-1 mutation to the NAT3 gene, which encodes the catalytic subunit of the NatB N-terminal acetyltransferase in Saccharomyces cerevisiae. Mutation of RAD56 causes sensitivity to X-rays, methyl methanesulfonate, zeocin, camptothecin and hydroxyurea, but not to UV light, suggesting that N-terminal acetylation of specific DNA repair proteins is important for efficient DNA repair.

Bidragets oversatte titel	Fysisk kortlægning og klonering af RAD56
Originalsprog	Engelsk
Tidsskrift	Gene
Vol/bind	519
Udgave nummer	1
Sider (fra-til)	182-186
Antal sider	5
ISSN	0378-1119
DOI	https://doi.org/10.1016/j.gene.2013.01.044
Status	Udgivet - 25 apr. 2013

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10.1016/j.gene.2013.01.044

http://www.sciencedirect.com/science/article/pii/S0378111913001170

Citationsformater

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title = "Physical mapping and cloning of RAD56",

abstract = "Here we report the physical mapping of the rad56-1 mutation to the NAT3 gene, which encodes the catalytic subunit of the NatB N-terminal acetyltransferase in Saccharomyces cerevisiae. Mutation of RAD56 causes sensitivity to X-rays, methyl methanesulfonate, zeocin, camptothecin and hydroxyurea, but not to UV light, suggesting that N-terminal acetylation of specific DNA repair proteins is important for efficient DNA repair.",

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T1 - Physical mapping and cloning of RAD56

AU - Mathiasen, David P

AU - Gallina, Irene

AU - Germann, Susanne Manuela

AU - Hamou, Wissam

AU - Eléouët, Morgane

AU - Thodberg, Sara

AU - Eckert-Boulet, Nadine

AU - Game, John

AU - Lisby, Michael

PY - 2013/4/25

Y1 - 2013/4/25

N2 - Here we report the physical mapping of the rad56-1 mutation to the NAT3 gene, which encodes the catalytic subunit of the NatB N-terminal acetyltransferase in Saccharomyces cerevisiae. Mutation of RAD56 causes sensitivity to X-rays, methyl methanesulfonate, zeocin, camptothecin and hydroxyurea, but not to UV light, suggesting that N-terminal acetylation of specific DNA repair proteins is important for efficient DNA repair.

AB - Here we report the physical mapping of the rad56-1 mutation to the NAT3 gene, which encodes the catalytic subunit of the NatB N-terminal acetyltransferase in Saccharomyces cerevisiae. Mutation of RAD56 causes sensitivity to X-rays, methyl methanesulfonate, zeocin, camptothecin and hydroxyurea, but not to UV light, suggesting that N-terminal acetylation of specific DNA repair proteins is important for efficient DNA repair.

U2 - 10.1016/j.gene.2013.01.044

DO - 10.1016/j.gene.2013.01.044

M3 - Journal article

C2 - 23403232

SN - 0378-1119

VL - 519

SP - 182

EP - 186

JO - Gene

JF - Gene

IS - 1

ER -

Physical mapping and cloning of RAD56

Abstract

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