Interleukin-26 (IL-26) is a novel anti-microbial peptide produced by T cells in response to staphylococcal enterotoxin

TY - JOUR

T1 - Interleukin-26 (IL-26) is a novel anti-microbial peptide produced by T cells in response to staphylococcal enterotoxin

AU - Woetmann, Anders

AU - Alhede, Morten

AU - Dabelsteen, Sally

AU - Bjarnsholt, Thomas

AU - Rybtke, Morten

AU - Nastasi, Claudia

AU - Krejsgaard, Thorbjørn

AU - Andersen, Mads Hald

AU - Bonefeld, Charlotte M

AU - Geisler, Carsten

AU - Givskov, Michael

AU - Odum, Niels

PY - 2018

Y1 - 2018

N2 - Anti-microbial peptides are produced at outer and inner surfaces by epithelia and innate immune cells in response to bacterial infection. Staphylococcus aureus is an enterotoxin producing, Gram-positive pathogen, which is a major cause of soft tissue infections and life-threatening bacteremia and sepsis. Here we show that (i) skin T cells in chronic wounds infected with S. aureus express interleukin-26 (IL-26) in situ, (ii) staphylococcal enterotoxins (SE) trigger IL-26 expression in T cell lines and primary skin T cells, and (iii) IL-26 triggers death and inhibits biofilm formation and growth of S. aureus. Thus, we provide novel evidence that IL-26 is an anti-microbial peptide produced by T cells in response to SE. Accordingly, we propose that IL-26 producing T cells take part in the innate immune response to SE producing S. aureus and thus play a novel role in the primary innate immune defense in addition to their classical role in adaptive immunity.

AB - Anti-microbial peptides are produced at outer and inner surfaces by epithelia and innate immune cells in response to bacterial infection. Staphylococcus aureus is an enterotoxin producing, Gram-positive pathogen, which is a major cause of soft tissue infections and life-threatening bacteremia and sepsis. Here we show that (i) skin T cells in chronic wounds infected with S. aureus express interleukin-26 (IL-26) in situ, (ii) staphylococcal enterotoxins (SE) trigger IL-26 expression in T cell lines and primary skin T cells, and (iii) IL-26 triggers death and inhibits biofilm formation and growth of S. aureus. Thus, we provide novel evidence that IL-26 is an anti-microbial peptide produced by T cells in response to SE. Accordingly, we propose that IL-26 producing T cells take part in the innate immune response to SE producing S. aureus and thus play a novel role in the primary innate immune defense in addition to their classical role in adaptive immunity.

KW - Antimicrobial peptide

KW - Chronic wounds

KW - IL-26

KW - Immune response

KW - Immunity

KW - Immunology: Immunology and Microbiology Section

KW - Staphylococcus aureus enterotoxins

KW - Superantigens staphylococcus pseudomonas

U2 - 10.18632/oncotarget.24603

DO - 10.18632/oncotarget.24603

M3 - Journal article

C2 - 29731960

SN - 1949-2553

VL - 9

SP - 19481

EP - 19489

JO - OncoTarget

JF - OncoTarget

IS - 28

ER -