Interleukin-26 (IL-26) is a novel anti-microbial peptide produced by T cells in response to staphylococcal enterotoxin

Anders Woetmann; Morten Alhede; Sally Dabelsteen; Thomas Bjarnsholt; Morten Rybtke; Claudia Nastasi; Thorbjørn Krejsgaard; Mads Hald Andersen; Charlotte M Bonefeld; Carsten Geisler; Michael Givskov; Niels Odum

doi:10.18632/oncotarget.24603

Interleukin-26 (IL-26) is a novel anti-microbial peptide produced by T cells in response to staphylococcal enterotoxin

Anders Woetmann, Morten Alhede, Sally Dabelsteen, Thomas Bjarnsholt, Morten Rybtke, Claudia Nastasi, Thorbjørn Krejsgaard, Mads Hald Andersen, Charlotte M Bonefeld, Carsten Geisler, Michael Givskov, Niels Odum

5 Citationer (Scopus)

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Abstract

Anti-microbial peptides are produced at outer and inner surfaces by epithelia and innate immune cells in response to bacterial infection. Staphylococcus aureus is an enterotoxin producing, Gram-positive pathogen, which is a major cause of soft tissue infections and life-threatening bacteremia and sepsis. Here we show that (i) skin T cells in chronic wounds infected with S. aureus express interleukin-26 (IL-26) in situ, (ii) staphylococcal enterotoxins (SE) trigger IL-26 expression in T cell lines and primary skin T cells, and (iii) IL-26 triggers death and inhibits biofilm formation and growth of S. aureus. Thus, we provide novel evidence that IL-26 is an anti-microbial peptide produced by T cells in response to SE. Accordingly, we propose that IL-26 producing T cells take part in the innate immune response to SE producing S. aureus and thus play a novel role in the primary innate immune defense in addition to their classical role in adaptive immunity.

Originalsprog	Engelsk
Tidsskrift	OncoTarget
Vol/bind	9
Udgave nummer	28
Sider (fra-til)	19481-19489
Antal sider	9
ISSN	1949-2553
DOI	https://doi.org/10.18632/oncotarget.24603
Status	Udgivet - 2018

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10.18632/oncotarget.24603Licens: CC BY

Interleukin-26 (IL-26) is a novel anti-microbial peptide produced by T cells in response to staphylococcal enterotoxinForlagets udgivne version, 1,6 MBLicens: CC BY

Citationsformater

Woetmann, A., Alhede, M., Dabelsteen, S., Bjarnsholt, T., Rybtke, M., Nastasi, C., Krejsgaard, T., Andersen, M. H., Bonefeld, C. M., Geisler, C., Givskov, M., & Odum, N. (2018). Interleukin-26 (IL-26) is a novel anti-microbial peptide produced by T cells in response to staphylococcal enterotoxin. OncoTarget, 9(28), 19481-19489. https://doi.org/10.18632/oncotarget.24603

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title = "Interleukin-26 (IL-26) is a novel anti-microbial peptide produced by T cells in response to staphylococcal enterotoxin",

abstract = "Anti-microbial peptides are produced at outer and inner surfaces by epithelia and innate immune cells in response to bacterial infection. Staphylococcus aureus is an enterotoxin producing, Gram-positive pathogen, which is a major cause of soft tissue infections and life-threatening bacteremia and sepsis. Here we show that (i) skin T cells in chronic wounds infected with S. aureus express interleukin-26 (IL-26) in situ, (ii) staphylococcal enterotoxins (SE) trigger IL-26 expression in T cell lines and primary skin T cells, and (iii) IL-26 triggers death and inhibits biofilm formation and growth of S. aureus. Thus, we provide novel evidence that IL-26 is an anti-microbial peptide produced by T cells in response to SE. Accordingly, we propose that IL-26 producing T cells take part in the innate immune response to SE producing S. aureus and thus play a novel role in the primary innate immune defense in addition to their classical role in adaptive immunity.",

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author = "Anders Woetmann and Morten Alhede and Sally Dabelsteen and Thomas Bjarnsholt and Morten Rybtke and Claudia Nastasi and Thorbj{\o}rn Krejsgaard and Andersen, {Mads Hald} and Bonefeld, {Charlotte M} and Carsten Geisler and Michael Givskov and Niels Odum",

year = "2018",

doi = "10.18632/oncotarget.24603",

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pages = "19481--19489",

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AU - Woetmann, Anders

AU - Alhede, Morten

AU - Dabelsteen, Sally

AU - Bjarnsholt, Thomas

AU - Rybtke, Morten

AU - Nastasi, Claudia

AU - Krejsgaard, Thorbjørn

AU - Andersen, Mads Hald

AU - Bonefeld, Charlotte M

AU - Geisler, Carsten

AU - Givskov, Michael

AU - Odum, Niels

PY - 2018

Y1 - 2018

N2 - Anti-microbial peptides are produced at outer and inner surfaces by epithelia and innate immune cells in response to bacterial infection. Staphylococcus aureus is an enterotoxin producing, Gram-positive pathogen, which is a major cause of soft tissue infections and life-threatening bacteremia and sepsis. Here we show that (i) skin T cells in chronic wounds infected with S. aureus express interleukin-26 (IL-26) in situ, (ii) staphylococcal enterotoxins (SE) trigger IL-26 expression in T cell lines and primary skin T cells, and (iii) IL-26 triggers death and inhibits biofilm formation and growth of S. aureus. Thus, we provide novel evidence that IL-26 is an anti-microbial peptide produced by T cells in response to SE. Accordingly, we propose that IL-26 producing T cells take part in the innate immune response to SE producing S. aureus and thus play a novel role in the primary innate immune defense in addition to their classical role in adaptive immunity.

AB - Anti-microbial peptides are produced at outer and inner surfaces by epithelia and innate immune cells in response to bacterial infection. Staphylococcus aureus is an enterotoxin producing, Gram-positive pathogen, which is a major cause of soft tissue infections and life-threatening bacteremia and sepsis. Here we show that (i) skin T cells in chronic wounds infected with S. aureus express interleukin-26 (IL-26) in situ, (ii) staphylococcal enterotoxins (SE) trigger IL-26 expression in T cell lines and primary skin T cells, and (iii) IL-26 triggers death and inhibits biofilm formation and growth of S. aureus. Thus, we provide novel evidence that IL-26 is an anti-microbial peptide produced by T cells in response to SE. Accordingly, we propose that IL-26 producing T cells take part in the innate immune response to SE producing S. aureus and thus play a novel role in the primary innate immune defense in addition to their classical role in adaptive immunity.

KW - Antimicrobial peptide

KW - Chronic wounds

KW - IL-26

KW - Immune response

KW - Immunity

KW - Immunology: Immunology and Microbiology Section

KW - Staphylococcus aureus enterotoxins

KW - Superantigens staphylococcus pseudomonas

U2 - 10.18632/oncotarget.24603

DO - 10.18632/oncotarget.24603

M3 - Journal article

C2 - 29731960

SN - 1949-2553

VL - 9

SP - 19481

EP - 19489

JO - Oncotarget

JF - Oncotarget

IS - 28

ER -

Interleukin-26 (IL-26) is a novel anti-microbial peptide produced by T cells in response to staphylococcal enterotoxin

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