Short presentation

The main focus of my research for the last years has been:

• Understanding the molecular mechanisms driving disease development of both cutaneous T cells lymphoma and benign skin inflammatory diseases.
• Understanding the role of bacterial derived metabolites in regulation of the innate and adaptive immune system in the skin, and how these impact cutanous disease development. 
• Furthermore, as part of my research focus, I have also been involved in the development of new tools for improved diagnostic distinction between benign, and malignant skin diseases (miRNA profiling, patent: WO2013011378-A1), and in development of new drug for treatment of cutaneous T cell lymphoma (pending patent: P017300DK1).

CV

CUR­RICULUM VITAE FOR:

Anders Woetmann (born 1967)                                                                                           

Work address: ISIM, Panum Institute 22.5.40 phone: 3532-7754

E-mail: [email protected]   

Academic Examinations, degrees ect

2015      Professor, University of Copenhagen

2009      Associate Professor, University of Copenhagen

2004      PhD., University of Copenhagen

1998      M.Sc., University of Copenhagen

Positions:

2016-                   Head of Studies: Master of Immunology and Inflammation.

2015-                   Professor MSO, ISIM, Faculty of Health Sciences, University of Copenhagen

2012-                   Associate professor, ISIM, Faculty of Health Sciences, University of Copenhagen

2009-2011           Associate professor, Department of Biology, University of Copenhagen

2005-                   Assistant Professor, Department of Biology, University of Copenhagen

2004-                   Assistant Professor, Institute for Medical Microbiology and Immunology,          University of Copenhagen

­2000-                   PhD student at University of Copenhagen

1998-                   Research fellow at University of Copenhagen

Publications and patents (May 2018):

Author of 93 papers published in international peer-reviewed journals.

Google Scholar: 3357 citations, H-index=32. Scopus: 2545 citations, H-index=27. Web of Science: 2389 citations, H-index=26.

Co-owner of patent number: WO2013011378-A1 and pending patent: P017300DK1.

Research interests:

Biology of skin immunity, inflammatory skin disorders, immune regulation, signal transduction, drug development, tumor immunology & biology, microbiota-immune system interactions

Science administration:

Member of the expert panel for biomedical sciences in the Icelandic research foundation (RANNIS). Editor for Nature Scientific Reports. Editor for APMIS.

PUBLICATIONS

93.       Fredholm S, Willerslev-Olsen A, Met Ö, Kubat L, Gluud M, Mathiasen SL, Friese C, Blümel E, Petersen DL, Hu T, Nastasi C, Lindahl LM, Buus TB, Krejsgaard T, Wasik MA, Kopp KL, Koralov SB, Persson JL, Bonefeld CM, Geisler C, Woetmann A, Iversen L, Becker JC, Odum N (2018) “Special AT rich-binding1 protein (SATB1) in malignant T cells”, J Invest Dermatol., pii: S0022-202X(18)31956-0. doi: 10.1016/j.jid.2018.03.1526. [Epub ahead of print].

92.       Woetmann A, Alhede M, Dabelsteen S, Bjarnsholt T, Rybtke M, Nastasi C, Krejsgaard T, Andersen MH, Bonefeld CM, Geisler C, Givskov and Odum N (2018) “Interleukin-26 (IL-26) is a novel anti-microbial peptide produced by T cells in response to staphylococcal enterotoxin”, Oncotarget, 13;9(28):19481-19489. doi: 10.18632/oncotarget.24603. eCollection 2018 Apr 13. PMID: 29731960.

91.       Ahmad SM, Martinenaite E, Holmström M, Jørgensen MA, Met Ö, Nastasi C, Klausen U, Donia M, Pedersen LM, Munksgaard L, Ødum N, Woetmann A, Svane IM, Andersen MH. (2018) “The inhibitory checkpoint, PD-L2, is a target for effector T cells: Novel possibilities for immune therapy”, Oncoimmunol.1;7(2):e1390641. doi: 10.1080/2162402X.2017.1390641. eCollection 2018

90.       Lindahl LM, Besenbacher S, Rittig AH, Celis P, Willerslev-Olsen A, Gjerdrum LMR, Krejsgaard T, Johansen C, Litman T, Woetmann A, Odum N, Iversen L. (2018) “Prognostic miRNA classifier in early-stage mycosis fungoides: development and validation in a Danish nationwide study”, Blood, 15;131(7):759-770. doi: 10.1182/blood-2017-06-788950.

89.       Netchiporouk E, Gantchev J, Tsang M, Thibault P, Watters AK, Hughes JM, Ghazawi FM, Woetmann A, Ødum N, Sasseville D, Litvinov IV. (2017) “Analysis of CTCL cell lines reveals important differences between mycosis fungoides/Sézary syndrome vs. HTLV-1+ leukemic cell lines”, Oncotarget, 8(56):95981-95998. doi: 10.18632/oncotarget.21619.

88.       Nastasi C, Fredholm S, Willerslev-Olsen A, Hansen M, Bonefeld CM, Geisler C, Andersen MH, Ødum N, Woetmann A. (2017) “Butyrate and propionate inhibit antigen-specific CD8₊ T cell activation by suppressing IL-12 production by antigen-presenting cells”, Sci. Rep., 6;7(1):14516. doi: 10.1038/s41598-017-15099-w.

87.       LauenborgB, Litvinov IV, Zhou Y, Willerslev-Olsen A, BonefeldCM, Nastasi C, Fredholm S, LindahlLM, SassevilleD, GeislerC, Wasik MM, KrejsgaardT, GjerdrumLMR, IversenL, OdumN & Woetmann A. (2017) “Malignant T cells activate endothelial cells via IL-17F”, Blood Cancer J., 7(7):e586. doi: 10.1038/bcj.2017.64.

86.       Pedersen DL, Berthelsen J, Willerslev-Olesen A, FredholmS, DabelsteenS, BonefeldCM, GeislerC & WoetmannA. (2017) “A novel BLK-induced tumor model”, Tumor Biology, 39(7):1010428317714196. doi: 10.1177/1010428317714196.

85.       Heftdal LD, Andersen T, Jæhger D, Woetmann A, Østgård R, Kenngott EE, Sieper USJ, Hvid M & Deleuran B. (2017) “Synovial cell production of IL-26 induces bone mineralization in spondyloarthritis”, J Mol Med., 95(7):779-787. doi: 10.1007/s00109-017-1528-2.

84.       Rode AKO, Kongsbak M, Hansen MM, Lopez DV, Levring TB, Woetmann A, Ødum N, Bonefeld CM & Geisler C. (2017) “Vitamin D Counteracts Mycobacterium tuberculosis-Induced Cathelicidin Downregulation in Dendritic Cells and Allows Th1 Differentiation and IFNγ Secretion.”, Front Immunol. 31;8:656. doi: 10.3389/fimmu.2017.00656.

83.       King SL, Joshi HJ, Schjoldager KT, Halim A, Madsen TD, Dziegiel MH, Woetmann A, Vakhrushev SY & Wandall HH. (2017) “Characterizing the O-glycosylation landscape of human plasma, platelets, and endothelial cells”, Blood Advances, 1(7):429-442. doi: 10.1182/bloodadvances.2016002121.

82.       Odum N, Lindahl LM, Wod M, Krejsgaard T, Skytthe A, Woetmann A, Iversen L & Christensen K. (2017) “Investigating heredity in cutaneous T-cell lymphoma in a unique cohort of Danish twins”, Blood Cancer J., 20;7(1):e517. doi: 10.1038/bcj.2016.128.

81.       Schmidt JD, Ahlström MG, Johansen JD, Dyring-Andersen B, Agerbeck C, Nielsen MM, Poulsen SS, Woetmann A, Ødum N, Thomsen AR, Geisler C & Bonefeld CM. (2016) “Rapid allergen-induced interleukin-17 and interferon-γ secretion by skin-resident memory CD8+ T cells”, Contact Dermatitis. 2017 Apr;76(4):218-227. doi: 10.1111/cod.12715. Epub 2016 Nov 22. PMID: 27873334.

80.       Krejsgaard T, Lindahl LM, Mongan NP, Wasik MA, Litvinov IV, Iversen L, Langhoff E, Woetmann A, Odum N. (2016) “Malignant inflammation in cutaneous T-cell lymphoma-a hostile takeover” Semin Immunopathol., doi: 10.1007/s00281-016-0594-9.

79.       Litvinov IV, Shtreis A, Kobayashi K, Glassman S, Tsang M, Woetmann A, Sasseville D, Ødum N, Duvic M. (2016) “Investigating potential exogenous tumor initiating and promoting factors for Cutaneous T-Cell Lymphomas (CTCL), a rare skin malignancy” Oncoimmunology, 5(7):e1175799. doi: 10.1080/2162402X.2016.1175799.

78.       Lindahl LM, Fredholm S, Joseph C, Nielsen BS, Jønson L, Willerslev-Olsen A, Gluud M, Blümel E, Petersen DL, Sibbesen N, Hu T, Nastasi C, Krejsgaard T, Jæhger D, Persson JL, Mongan N, Wasik MA, Litvinov IV, Sasseville D, Koralov SB, Bonefeld CM, Geisler C, Woetmann A, Ralfkiaer E, Iversen L, Odum N. (2016) “STAT5 induces miR-21 expression in cutaneous T cell lymphoma” Oncotarget, doi: 10.18632/oncotarget.10160, 19;7(29):45730-45744. doi: 10.18632/oncotarget.10160.

77.       Fredholm S, Litvinov IV, Mongan NP, Schiele S, Willerslev-Olsen A, Petersen DL, Krejsgaard T, Sibbesen N, Nastasi C, Bonefeld CM, Persson JL, Straten PT, Andersen MH, Koralov SB, Wasik MM, Geisler C, Sasseville D, Woetmann A, Ødum N. (2016) “The Expression of IL-21 Is Promoted by MEKK4 in Malignant T Cells and Associated with Increased Progression Risk in Cutaneous T-Cell Lymphoma” J Invest Dermatol., 136(4):866-869.

76.       Willerslev-Olsen A, Krejsgaard T, Lindahl LM, Litvinov IV, Fredholm S, Petersen DL, Nastasi C, Gniadecki R, Mongan NP, Sasseville D, Wasik MA, Bonefeld CM, Geisler C, Woetmann A, Iversen L, Kilian M, Koralov SB, Odum N. (2016) “Staphylococcal enterotoxin A (SEA) stimulates STAT3 activation and IL-17 expression in cutaneous T-cell lymphoma” Blood, 127(10):1287-1296.

75.       Nastasi, C., Candela, M., Bonefeld, C.M., Geisler, C., Hansen, M., Krejsgaard, T., Biagi, E., Andersen, M.H., Brigidi, P., Ødum, N., Litman, T., Woetmann A.  (2015) “The effect of short-chain fatty acids on human monocyte-derived dendritic cells” Sci. Rep. 6;5:16148. doi: 10.1038/srep16148.

74.       Levring TB, Kongsbak M, Rode AK, Woetmann A, Ødum N, Bonefeld CM, Geisler C. (2015) “Human CD4+ T cells require exogenous cystine for glutathione and DNA synthesis” Oncotarget, 6(26):21853-21864.

73.       Sibbesen NA, Kopp KL, Litvinov IV, Jønson L, Willerslev-Olsen A, Fredholm S, Petersen DL, Nastasi C, Krejsgaard T, Lindahl LM, Gniadecki R, Mongan NP, Sasseville D, Wasik MA, Iversen L, Bonefeld CM, Geisler C, Woetmann A, Odum N. (2015) “Jak3, STAT3, and STAT5 inhibit expression of miR-22, a novel tumor suppressor microRNA, in cutaneous T-Cell lymphoma” Oncotarget, 6(24):20555-20569.

72.       Bagdonaite I, Wandall HH, Litvinov IV, Nastasi C, Becker JC, Dabelsteen S, Geisler C, Bonefeld CM, Zhang Q, Wasik MA, Zhou Y, Sasseville D, Ødum N, Woetmann A. (2015) “Ectopic expression of a novel CD22 splice-variant regulates survival and proliferation in malignant T cells from cutaneous T cell lymphoma (CTCL) patients” Oncotarget, 6(16):14374-14384.

71.       Boding L, Hansen AK, Meroni G, Levring TB, Woetmann A, Ødum N, Bonefeld CM, Geisler C. (2015) “MID2 can substitute for MID1 and control exocytosis of lytic granules in cytotoxic T cells” APMIS., 123(8):682-7.

70.       Lauenborg B, Christensen L, Ralfkiaer U, Kopp KL, Jønson L, Dabelsteen S, Bonefeld CM, Geisler C, Gjerdrum LM, Zhang Q, Wasik MA, Ralfkiaer E, Ødum N, Woetmann A. (2015) “Malignant T cells express lymphotoxin α and drive endothelial activation in cutaneous T cell lymphoma” Oncotarget., 6(17):15235-15249.

69.       Boding L, Hansen AK, Nielsen MM, Meroni G, Braunstein TH, Woetmann A, Ødum N, Bonefeld CM, Geisler C. (2015) “Midline 1 controls polarization and migration of murine cytotoxic T cells”, Immun Inflamm Dis., 2(4):262-271.

68.       Nielsen MM, Dyring-Andersen B, Schmidt JD, Witherden D, Lovato P, Woetmann A, Ødum N, Poulsen SS, Havran WL, Geisler C, Bonefeld CM. (2015) “NKG2D-dependent activation of dendritic epidermal T cells in contact hypersensitivity” J Invest Dermatol., 135(5):1311-1319.

67.       Thode, C., Woetmann, A., Wandall, H.H., Carlsson, M.C., Qvortrup, K., Kauczok, C.S., Wobser, M., Printzlau, A., Odum, N. & Dabelsteen, S. (2015) “Malignant T cells secrete galectins and induce epidermal hyperproliferation and disorganized stratification in a skin model of cutaneous T-cell lymphoma” J. Invest. Dermatol., (1):238-246.

66.       Litvinov IV, Netchiporouk E, Cordeiro B, Zargham H, Pehr K, Gilbert M, Zhou Y, Moreau L, Woetmann A, Ødum N, Kupper TS, Sasseville D. (2014) “Ectopic expression of embryonic stem cell and other developmental genes in cutaneous T-cell lymphoma” Oncoimmunology, 3(11):e970025.

65.       Ralfkiaer U, Lindahl LM, Litman T, Gjerdrum LM, Ahler CB, Gniadecki R, Marstrand T, Fredholm S, Iversen L, Wasik MA, Bonefeld CM, Geisler C, Krejsgaard T, Glue C, Røpke MA, Woetmann A, Skov L, Grønbæk K, Odum N. (2014) “MicroRNA expression in early mycosis fungoides is distinctly different from atopic dermatitis and advanced cutaneous T-cell lymphoma” Anticancer Res., 34(12):7207-7217.

64.       Litvinov, I.V., Cordeiro, B., Fredholm, S., Odum, N., Zargham, H., Huang, Y., Zhou, Y., Pehr, K., Kupper, T.S., Woetmann A. & Sasseville, D. (2014) “Analysis of STAT4 expression in cutaneous T-cell lymphoma (CTCL) patients and patient-derived cell lines”,Cell Cycle, 13(18):2975-82

63.       Fredholm, S., Gjerdrum, L.M., Willerslev-Olsen, A., Petersen, D.L., Nielsen, I.Ø., Kauczok, C.S., Wobser, M., Ralfkiaer, U., Bonefeld, C.M., Wasik, M.A., Krejsgaard, T., Geisler, C., Ralfkiaer, E., Gniadecki, R., Woetmann, A. & Odum, N. (2014) “STAT3 activation and infiltration of eosinophil granulocytes in mycosis fungoides”, Anticancer Res., 34(10):5277-5286.

62.       Kongsbak, M., von Essen, M., Levring, T., Schjerling, P., Woetmann, A., Odum, N., Bonefeld, C. & Geisler, C. (2014) “Vitamin D-binding protein controls T cell responses to vitamin D”, BMC Immunol., 15(1):35. [Epub ahead of print]

61.       Radhakrishnan P, Dabelsteen S, Madsen FB, Francavilla C, Kopp KL, Steentoft C, Vakhrushev SY, Olsen JV, Hansen L, Bennett EP, Woetmann A, Yin G, Chen L, Song H, Bak M, Hlady RA, Peters SL, Opavsky R, Thode C, Qvortrup K, Schjoldager KT, Clausen H, Hollingsworth MA. & Wandall HH. (2014) “Immature truncated O-glycophenotype of cancer directly induces oncogenic features”, Proc. Natl. Acad. Sci. U.S.A., 111(39):E4066-4075.

60.       Boding, L., Hansen, A.K., Meroni, G., Johansen, B.B., Braunstein, T.H., Bonefeld, C.M., Kongsbak, M., Jensen, B.A., Woetmann, A., Thomsen, A.R., Odum, N., von Essen, M.R. & Geisler, C. (2014) “Midline 1 directs lytic granule exocytosis and cytotoxicity of mouse killer T cells”, Eur. J. Immunol., 44(10):3109-3118.

59.       Vennegaard, M.T., Dyring-Andersen, B., Skov, L., Nielsen, M.M., Schmidt, J.D., Bzorek, M., Poulsen, S.S., Thomsen, A.R., Woetmann, A., Thyssen, J.P., Johansen, J.D., Odum, N., Menné , T., Geisler, C. & Bonefeld, C.M. (2014) “Epicutaneous exposure to nickel induces nickel allergy in mice via a MyD88-dependent and interleukin-1-dependent pathway”, Contact Dermatitis, 71(4):224-232.

58.       Krejsgaard, T., Willerslev-Olsen, A., Lindahl, L.M., Bonefeld, C.M., Koralov, S.B., Geisler, C., Wasik, M.A., Gniadecki, R., Kilian, M., Iversen, L., Woetmann, A. & Odum, N. (2014) “Staphylococcal enterotoxins stimulate lymphoma-associated immune dysregulation”, Blood, 124(5):761-770

57.       Petersen, D.L., Krejsgaard, T., Berthelsen, J., Fredholm, S., Willerslev-Olsen, A., Sibbesen, N.A., Bonefeld, C.M., Andersen, M.H., Francavilla, C., Olsen, J.V., Hu, T., Zhang, M., Wasik, M.A., Geisler, C., Woetmann, A. & Odum, N. (2014) “B-lymphoid tyrosine kinase (Blk) is an oncogene and a potential target for therapy with dasatinib in cutaneous T-cell lymphoma (CTCL)”, Leukemia, 28(10):2109-2112.

56.       Kongsbak, M., von Essen, M.R., Boding, L., Levring, T.B., Schjerling, P., Lauritsen, J.P., Woetmann, A., Odum, N., Bonefeld, C.M. & Geisler, C. (2014) “Vitamin D Up-Regulates the Vitamin D Receptor by Protecting It from Proteasomal Degradation in Human CD4+ T Cells” PLoS One, 9(5):e96695.

55.       Willerslev-Olsen, A., Litvinov, I.V., Fredholm, S.M., Petersen, D.L., Sibbesen, N.A., Gniadecki, R., Zhang, Q., Bonefeld, C.M., Wasik, M.A., Geisler, C., Zhou, Y., Woetmann, A., Sasseville, D., Krejsgaard, T. & Odum N (2014) “IL-15 and IL-17F are differentially regulated and expressed in mycosis fungoides (MF)” Cell Cycle, 15; 13(8):1306-1312.

54.       Nielsen, M.M., Lovato, P., MacLeod, A.S., Witherden, D.A., Skov, L., Dyring-Andersen, B., Dabelsteen, S., Woetmann, A., Ødum, N., Havran, W.L., Geisle,r C. & Bonefeld, C.M. (2014) “IL-1β-dependent activation of dendritic epidermal T cells in contact hypersensitivity” J Immunol., 1; 192(7):2975-2983.

53.       Zhang, Q., Wang, H.Y., Wei, F., Liu, X., Paterson, J.C., Roy, D., Mihova, D., Woetmann, A., Ptasznik, A., Odum, N., Schuster, S.J., Marafioti, T., Riley, J.L. & Wasik, M.A. (2014) “Cutaneous T cell lymphoma expresses immunosuppressive CD80 (B7-1) cell surface protein in a STAT5-dependent manner” J Immunol., 15; 192(6):2913-9

52.       Marzec, M., Halasa, K.,  Liu, X.,  Wang, H.Y., Cheng, M., Baldwin, D.,  Tobias, J.W.,  Schuster, S.J., Woetmann, A.,  Zhang, Q., Turner, S.D., Odum, N. & Wasik, M.A. (2013) “Malignant transformation of CD4+ T lymphocytes mediated by oncogenic kinase NPM/ALK recapitulates IL-2-induced cell signaling and gene expression reprogramming" J. Immunol., 15; 191(12): 6200-6207.

51.       Kopp, K.L., Ralfkiaer, U., Nielsen, B.S., Gniadecki, R., Woetmann, A., Odum, N. & Ralfkiaer, E. (2013) “Expression of miR-155 and miR-126 in situ in cutaneous T-cell lymphomas” APMIS, 121 (11): 1020-1024.

50.       Willerslev-Olsen, A., Krejsgaard, T., Lindahl, L.M., Bonefeld, C.M., Wasik, M.A., Koralov, S.B., Geisler, C., Kilian, M., Iversen, L., Woetmann, A. & Odum, N. (2013) “Bacterial toxins fuel disease progression in cutaneous T-cell lymphoma” Toxins, 5(8): 1402-1421.

49.       Larsen, S.K., Munir, S., Woetmann, A., Frøsig, T.M., Odum, N., Svane, I.M., Becker, J.C. & Andersen, M.H. (2013) “Functional characterization of Foxp3-specific spontaneous immune responses”, Leukemia, 27(12):2332-2340.

48.       Krejsgaard, T., Litvinov, I.V., Wang, Y., Xia, L., Willerslev-Olsen, A., Koralov, S.B.,  Kopp, K.L., Bonefeld, C.M., Wasik, M.A., Geisler, C., Woetmann, A., Zhou, Y., Sasseville, D. & Odum, N. (2013) “Elucidating the role of interleukin-17F in cutaneous T-cell lymphoma” Blood, 122(6): 943-950.

47.       Marstrand, T., Ahler, C.B., Ralfkiaer, U., Clemmensen, A., Kopp, K.L., Sibbesen, N.A., Krejsgaard, T., Litman, T., Wasik, M.A., Bonefeld, C.M., Grønbæk, K., Gjerdum, L.M., Gniadecki, R., Ralfkiaer, E., Geisler, C., Woetmann, A., Røpke, M.A., Glue, C., Skov, L. & Odum, N. (2013) “Validation of a diagnostic miRNA classifier in cutaneous T-cell lymphomas” Leuk. Lymphoma, 55(4):957-958.

46.       Kopp, K.L., Ralfkiaer, U., Gjerdrum, L.M., Helvad, R., Pedersen, I.H., Litman, T., Jønson, L., Hagedorn, P.H., Krejsgaard, T., Gniadecki, R., Bonefeld, C.M,. Skov, L., Geisler, C., Wasik, M.A., Ralfkiae,r E., Odum, N. & Woetmann, A. (2013) “STAT5-mediated expression of oncogenic miR-155 in cutaneous T-cell lymphoma” Cell Cycle, 12(12): 1939-1947.

45.       Munir, S., Andersen, G.H., Woetmann, A., Odum, N., Becker, J.C. & Andersen, M.H. (2013) “Cutaneous T cell lymphoma cells are targets for immune checkpoint ligand PD-L1-specific, cytotoxic T cells”, Leukemia, 27(11):2251-2253.

44.       Falkencrone, S., Poulsen, L.K., Bindslev-Jensen, C., Woetmann, A., Odum, N., Poulsen, B.C., Blom, L., Jensen, B.M., Gibbs, B.F., Yasinska, I.M., Sumbayev, V.V. & Skov, P.S. (2013) “IgE-mediated basophil tumour necrosis factor alpha induces matrix metalloproteinase-9 from monocytes”, Allergy, 68(5): 614-620.

43.       Manfè, V., Biskup, E., Willumsgaard, A., Skov, A.G., Palmieri, D., Gasparini, P., Laganá, A., Woetmann, A., Ødum, N., Croce, C.M. & Gniadecki, R. (2013) “cMyc/miR-125b-5p signalling determines sensitivity to bortezomib in preclinical model of cutaneous T-cell lymphomas”, PLoS One, 8(3): e59390.

42.       von Essen, M.R., Kongsbak, M., Levring, T.B., Hansen, A.K., Boding, L., Lauritsen, J.P., Woetmann, A., Baier, G., Odum, N., Bonefeld, C.M. & Geisler, C. (2013) “PKC-θ exists in an oxidized inactive form in naive human T cells”, Eur. J. Immunol., 43(6): 1659-1666.

41.       Ryder, L.R., Ryder, L.P., Bartels, E.M., Woetmann, A., Madsen, H.O., Ødum, N., Danneskiold-Samsøe, B., Ribel-Madsen, S. & Bliddal, H. (2013) ”Differential effects of decoy receptor- and antibody-mediated tumour necrosis factor blockage on FoxP3 expression in responsive arthritis patients”, APMIS, 121(4): 337-347.

40.       Pedersen, I.H., Willerslev-Olsen, A., Vetter-Kauczok, C., Krejsgaard, T., Lauenborg, B., Kopp, K.L., Geisler, C., Bonefeld, C.M., Zhang, Q., Wasik, M.A., Dabelsteen, S., Woetmann, A., Becker, J.C. & Odum, N. (2013) “Vascular endothelial growth factor receptor-3 expression in mycosis fungoides”, Leuk. Lymphoma, 54(4): 819-826

39.       Lavrsen, K, Madsen, C.B., Rasch, M.G., Woetmann, A., Ødum, N., Mandel, U., Clausen, H., Pedersen, A.E. & Wandall, H.H. (2013) “Aberrantly glycosylated MUC1 is expressed on the surface of breast cancer cells and a target for antibody-dependent cell-mediated cytotoxicity”, Glycoconj. J., 30(3): 227-236.

38.       Vennegaard, M.T., Bonefeld, C.M., Hagedorn, P.H., Bangsgaard, N., Løvendorf, M.B., Odum, N., Woetmann, A., Geisler, C. & Skov, L. (2012) “Allergic contact dermatitis induces upregulation of identical microRNAs in humans and mice”, Contact Dermatitis., 67(5): 298-305.

37.       Ryder, L.R., Bartels, E.M., Woetmann, A., Madsen, H.O., Odum, N., Bliddal, H., Danneskiold-Samsøe, B., Ribel-Madsen, S. & Ryder, L.P. (2012) ”FoxP3 mRNA splice forms in synovial CD4+ T cells in rheumatoid arthritis and psoriatic arthritis”, APMIS, 120 (5): 387-396.

36.       Levring, T.B., Hansen, A.K., Nielsen, B.L., Kongsbak, M., von Essen, M.R., Woetmann, A., Odum, N., Bonefeld, C.M. & Geisler, C. (2012) ”Activated human CD4 T cells express transporters for both cysteine and cystine”, Sci. Rep., 2: 266

35.       Kantekure, K., Yang, Y., Raghunath, P., Schaffer, A., Woetmann, A., Zhang, Q., Odum, N. & Wasik, M. (2012) “Expression patterns of the immunosuppressive proteins PD-1/CD279 and PD-L1/CD274 at different stages of cutaneous T-cell lymphoma/mycosis fungoides”, Am. J. Dermatopathol. 34 (1): 126-128.

34.       Krejsgaard, T., Odum, N., Geisler, C., Wasik, M.A. & Woetmann, A. (2012) “Regulatory T cells and immunodeficiency in mycosis fungoides and Sézary syndrome”, Leukemia. 26 (3): 424-432.

33.       Ralfkiaer, U., Hagedorn, P.H., Bangsgaard, N., Løvendorf, M.B., Ahler, C.B., Svensson, L., Kopp, K.L., Vennegaard, M.T., Lauenborg, B., Zibert, J.R., Krejsgaard, T., Bonefeld, C.M., Søkilde, R., Gjerdrum, L.M., Labuda, T., Mathiesen, A.M., Grønbæk, K., Wasik, M.A., Sokolowska-Wojdylo, M., Queille-Roussel, C., Gniadecki,          R., Ralfkiaer, E., Geisler, C., Litman, T., Woetmann, A., Glue, C., Røpke, M.A., Skov,    L., Odum, N. (2011) “Diagnostic microRNA profiling in cutanous T-cell lymphoma (CTCL)”, Blood, 118 (22): 5891-5900.

32.       Hansen. M.L., Woetmann, A., Krejsgaard, T., Kopp, K.L., Søkilde, R., Litman, T., Straten, P.T., Geisler, C., Wasik, M.A., Odum, N. & Eriksen, K.W. (2011) ”IFN-α primes T- and NK-cells for IL-15-mediated signaling and cytotoxicity”, Mol. Immunol., 48 (15-16): 2087-2093.

31.       Krejsgaard, T., Ralfkiaer, U., Clasen-Linde, E., Eriksen, K.W., Kopp, K.L., Bonefeld, C.M., Geisler, C, Dabelsteen, S., Wasik, M.A., Ralfkiaer, E., Woetmann, A. & Odum N. (2011) “Malignant cutaneous T-cell lymphoma cells express IL-17 utilizing the Jak3/Stat3 signaling pathway”, J. Invest. Dermatol., 131 (6): 1331-1338.

30.       Marzec, M., Liu, X., Wong, W., Yang, Y., Pasha, T., Kantekure, K., Zhang, P., Woetmann, A., Cheng, M., Odum, N., Wasik, M.A. (2010) “Oncogenic kinase NPM/ALK induces expression of HIF1α mRNA”, Oncogene, 30 (11): 1372-1378.

29.       Kopp, K.L., Dabelsteen, S., Krejsgaard, T., Eriksen, K.W., Geisler, C., Becker, J.C., Wasik, M., Ødum, N., Woetmann, A. (2010) “COX-2 is a novel target in therapy of mycosis fungoides” Leukemia, 24 (12): 2127-2129.

28.       Krejsgaard, T., Kopp, K., Ralfkiaer, E., Willumsgaard, A.E., Eriksen, K.W., Labuda, T., Rasmussen, S., Mathiesen, A.M., Geisler, C., Lauenborg, B., Becker, J.C., Zhang, Q., Wasik, M.A., Odum, N., Woetmann, A. (2010) “A novel xenograft model of cutaneous T-cell lymphoma”, Exp. Dermatol., 19 (12): 1096-1102.

27.       Kamstrup, M.R., Gjerdrum, L.M., Biskup, E., Lauenborg, B.T., Ralfkiaer, E., Woetmann, A., Ødum, N. & Gniadecki, R. (2010) “Notch1 as a potential target in cutaneous T-cell lymphoma”, Blood, 116 (14): 2504-2512.

26.       Ryder, R.L.,  Woetmann, A., Madsen, H.O., Ødum, N., Ryder, L.P., Bliddal, H., Danneskiold-Samsøe, B., Ribel-Madsen, S. & Bartels, E.M. (2010) ”Expression of full length and splice forms of FoxP3 in rheumatoid arthritis”,  Scand. J. Rheumatol., 39 (4): 279-286.

25.       Kopp, K.L., Kauczok, C.S., Lauenborg, B., Krejsgaard, T., Eriksen, K.W., Zhang, Q., Wasik, M.A., Geisler, C., Ralfkiaer, E., Becker, J.C., Ødum, N. & Woetmann, A. (2010) “COX-2-dependent PGE(2) acts as a growth factor in mycosis fungoides (MF)”, Leukemia, 24 (6): 1179-1185.

24.       Eriksen, K.W., Woetmann, A., Skov, L., Krejsgaard, T., Bovin, L.F., Hansen, M.L., Grønbeck, K., Billestrup, N., Nissen, M.H., Geisler, C., Wasik, M.A. & Odum, N. (2010) “Deficient SOCS3 and SHP-1 expression in psoriatic T cells”, J. Invest. Dermatol., 130 (6): 1590-1597.

23.       Krejsgaard, T., Helvad, R., Ralfkiaer, E., Astvad, K., Grønbæk, K., Eriksen, K.W., Geisler, C., Kopp, K., Zhang, Q., Odum, N. & Woetmann, A. (2010) “Malignant T cells exhibit CD45 resistant Stat3 activation and proliferation in cutaneous T-cell lymphoma”, Open Leukemia J., 3: 9-15.

22.       Lauenborg, B., Kopp, K., Krejsgaard, T., Eriksen, K.W., Geisler, C., Dabelsteen, S., Gniadecki, R. Zhang, Q., Wasik, M.A., Woetmann, A. & Odum, N. (2010) “Programmed cell death 10 (PDCD10) enhances proliferation and protects malignant T cells from apoptosis”, APMIS, 118(10): 719-728.

21.       Krejsgaard, T., Vetter-Kauczok, C.S., Woetmann, A., Kneitz, H., Eriksen, K.W., Lovato, P., Zhang, Q., Wasik, M.A., Geisler, C., Ralfkiaer, E., Becker, J.C. & Odum, N. (2009) “Ectopic expression of B-lymphoid kinase in cutaneous T-cell lymphoma”, Blood., 113 (23): 5896-5904.

20.       Erikesen, K.W, Søndergaard, H., Woetmann, A., Krejsgaard, T., Skak, K., Geisler, C., Wasik, M.A. & Odum, N. (2009) “The combination of IL-21 and IFN-alpha boosts STAT3 activation, cytotoxicity and experimental tumor therapy” Mol. Immunol., 46 (5): 812-820.

19.       Krejsgaard, T., Gjerdrum, L.M., Ralfkiaer, E., Lauenborg, B., Eriksen, K.W., Mathiesen, A.M., Bovin, L.F., Gniadecki, R., Geisler, C., Ryder, L.P., Zhang, Q., Wasik, M.A, Odum, N. & Woetmann, A. (2008) “Malignant Tregs express low molecular splice forms of FOXP3 in Sézary syndrome”, Leukemia, 22(12): 2230-2239.

18.       Kasprzycka, M., Zhang, Q., Witkiewicz, A., Marzec, M., Potoczek, M., Liu, X., Wang, H.Y., Milone, M., Basu, S., Mauger, J., Choi, J.K., Abrams, J.T., Hou, J.S., Rook, A.H., Vonderheid, E., Woetmann, A., Odum, N. & Wasik, M.A. (2008) “Gamma c-signaling cytokines induce a regulatory T cell phenotype in malignant CD4+ T lymphocytes”, J. Immunol., 181(4): 2506-2512.

17.       Gjerdrum, L.M., Woetmann, A., Odum, N., Hother, C., Henrik-Nielsen, R., Gniadecki, R. & Ralfkiaer, E. (2008) “FOXP3 positive regulatory T-cells in cutaneous and systemic CD30 positive T-cell lymphoproliferations” Eur. J. Haematol., 80(6): 483-489.

16.       Andersen, P., Pedersen, M.W., Woetmann, A., Villingshøj, M., Stockhausen, M.T., Odum, N. & Poulsen H.S. (2008) “EGFR induces expression of IRF-1 via STAT1 and STAT3 activation leading to growth arrest of human cancer cells” Int. J. Cancer, 122 (2): 342-349.

15.       Gjerdrum, L.M., Woetmann, A., Odum, N., Burton, C.M., Rossen, K., Skovgaard, G.L., Ryder, L.P. & Ralfkiaer, E. (2007) “FOXP3+ regulatory T cells in cutaneous T-cell lymphoma: association with disease stage and survival”, Leukemia, 21 (12): 2512-2518.

14.       Woetmann, A., Lovato, P., Eriksen, K.W., Krejsgaard, T., Labuda, T., Zhang, Q., Mathiesen, A-M., Gesiler, C., Svejgaard, A., Wasik, M.A. & Ødum, N. (2007) ”Nonmalignant T cells stimulate growth of T-cell lymphoma cells in the presence of bacterial toxins”, Blood, 190 (8): 3325-3332.

13.       Sønder, S.U., Woetmann, A., Ødum, N. & Bendtzen, K. (2006) “Spironolactone induced apoptosis and inhibits Nf-kappaB independent of the mineralocorticoid receptor” Apoptosis, 11 (12): 2159-2165.

12.       Krejsgaard, T., Vetter-Kauczok, C.S., Woetmann, A., Lovato, P., Labuda, T., Eriksen, K.W., Zhang, Q., Becker, J.C. & Ødum, N. (2006) “Jak3- and JNK-dependent vascular endothelial growth factor expression in cutanous T-cell lymphoma”, Leukemia, 20 (10): 1759-1766.

11.       Zhang, Q., Wang, H.Y., Woetmann, A., Raghunath, P.N., Ødum, N. & Wasik M.A. (2006) “STAT3 induces transcription of the DNA methyltransferse 1 gene (DNMT1) in malignant T lymphocytes” Blood, 108 (3): 1058-1064.

10.       Skov, S., Pedersen, M.T., Andresen, L, Straten, P.T., Woetmann, A. & Ødum, N. (2005) ”Cancer cells become susceptible to natural killer cell killing after exposure to histone deacetylase inhibitors due to glycogen synthase kinase-3-dependent expression of MHC class I-related chain A and B”, Cancer Res. 65 (23): 11136-11145.

9.         Brender, C.,  Lovato, P., Sommer, V.H., Woetmann, A., Mathiessen, A.M., Geisler, C., Wasik, M.A., & Ødum, N. (2005) “Constitutive SOCS-3 expression protects T cell lymphoma against growth inhibition by IFN-α”, Leukemia, 19 (2): 209-213.

8.         Sommer, V.H., Clemmensen, O.J., Nielsen, O., Wasik, M., Lovato, P., Brender, C., Eriksen, K.W., Woetmann, A., Kaestel, C.G., Nissen, M.H., Röpke, C., Skov, S. & Ødum, N. (2004) "In vivo activation of STAT3 in cutaneous T cell lymphoma. Evidence for an antiapoptotic function of STAT3", Leukemia, 18 (7): 1288-1295.

7.         Eriksen, K.W., Sommer, V.H., Woetmann, A., Rasmussen, A.B., Brender, C., Svejgaard, A., Skov, S., Geisler, C. & Ødum. N. (2003) “Bi-phasic effect of IFN-a: IFN-a up- and down-regulates IL-4-signaling in human T-cells”, J.Biol.Chem. 279 (1): 169-176.

6.         Woetmann, A., Brockdorff, J.L., Lovato, P., Nielsen, M., Leick, V., Rieneck, K., Svejgaard, A., Geisler, C. & Ødum, N. (2003) “Protein phosphatase 2A (PP2A) regulates IL-4 mediated STAT6 signaling” J.Biol. Chem., 278 (5): 2787-2791.

5.         Lovato, P., Brender, C., Agnholt, J.,Kelsen, J., Kaltoft, K., Svejgaard, A., Eriksen, K.W.,  Woetmann, A. & Ødum, N. (2003) "Constitutive Stat3 activation in intestinal T cells from patients with Crohn's disease" J.Biol. Chem., 278 (19): 16777-16781.

4.         Brockdorff, J.L., Woetmann, A., Mustelin, T., Kaltoft, K., Zhang, Q., Wasik, M.A., Röpke, C. & Ødum, N. (2002) “SHP2 regulates IL-2 induced MAPK activation, but not Stat3 or Stat5 activation, in mycosis fungoides derived tumor T cells”, Cytokine, 20 (4):141-147.

3.         Woetmann, A., Nielsen, M., Christensen, S.T., Brockdorff, J., Kaltoft, K., Skov, S.,

Brender, C., Svejgaard, A., Leick, V. & Ødum, N. (1999) “Inhibition of protein phosphatase PP2A induces serine/threonine phosphorylation and functional inhibition of STAT3",  Proc.Natl. Acad. Sci. U.S.A., 96 (19): 10620-10625.

2.         Nielsen, M., Kæstel, C.G., Eriksen, K.W., Woetmann, A., Stokkedal, T., Geisler, C., Röpke,C. & Ødum, N. (1999) “Inhibition of constitutively activated Stat3 correlates with altered Bcl-2/Bax expression and induction of apoptosis in mycosis fungoides tumor cells”,Leukemia. 13 (5): 735-738

1.         Amos, C.L., Woetmann, A., Nielsen, M., Geisler, C., Ødum, N., Brown, B.L. & Dobson, P.R.M. (1998) ”The role of caspase3 and BclxL in the action of interleukin 7 (IL-7): a survival factor in activated human T cells”, Cytokine, 10 (9): 662-668.