Factors Affecting the Absorption of Subcutaneously Administered Insulin: Effect on Variability

Anna Katrina Jógvansdóttir Gradel; Trine Porsgaard; Jens Lykkesfeldt; Torben Seested; Sanne Gram-Nielsen; Niels Rode Kristensen; Hanne Refsgaard

doi:10.1155/2018/1205121

Factors Affecting the Absorption of Subcutaneously Administered Insulin: Effect on Variability

Anna Katrina Jógvansdóttir Gradel, Trine Porsgaard, Jens Lykkesfeldt, Torben Seested, Sanne Gram-Nielsen, Niels Rode Kristensen, Hanne Refsgaard

Lifepharm

26 Citations (Scopus)

85 Downloads (Pure)

Abstract

Variability in the effect of subcutaneously administered insulin represents a major challenge in insulin therapy where precise dosing is required in order to achieve targeted glucose levels. Since this variability is largely influenced by the absorption of insulin, a deeper understanding of the factors affecting the absorption of insulin from the subcutaneous tissue is necessary in order to improve glycaemic control and the long-term prognosis in people with diabetes. These factors can be related to either the insulin preparation, the injection site/patient, or the injection technique. This review highlights the factors affecting insulin absorption with special attention on the physiological factors at the injection site. In addition, it also provides a detailed description of the insulin absorption process and the various modifications to this process that have been utilized by the different insulin preparations available.

Original language	English
Article number	1205121
Journal	Journal of Diabetes Research
Volume	2018
Number of pages	17
ISSN	2314-6745
DOIs	https://doi.org/10.1155/2018/1205121
Publication status	Published - 2018

Keywords

Faculty of Health and Medical Sciences

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1155/2018/1205121Licence: CC BY

Factors Affecting the Absorption of Subcutaneously Administered Insulin: Effect on VariabilityFinal published version, 2.17 MBLicence: CC BY

Cite this

@article{96743695f9614d47a129af7b61eb8c0a,

title = "Factors Affecting the Absorption of Subcutaneously Administered Insulin: Effect on Variability",

abstract = "Variability in the effect of subcutaneously administered insulin represents a major challenge in insulin therapy where precise dosing is required in order to achieve targeted glucose levels. Since this variability is largely influenced by the absorption of insulin, a deeper understanding of the factors affecting the absorption of insulin from the subcutaneous tissue is necessary in order to improve glycaemic control and the long-term prognosis in people with diabetes. These factors can be related to either the insulin preparation, the injection site/patient, or the injection technique. This review highlights the factors affecting insulin absorption with special attention on the physiological factors at the injection site. In addition, it also provides a detailed description of the insulin absorption process and the various modifications to this process that have been utilized by the different insulin preparations available.",

keywords = "Faculty of Health and Medical Sciences",

author = "Gradel, {Anna Katrina J{\'o}gvansd{\'o}ttir} and Trine Porsgaard and Jens Lykkesfeldt and Torben Seested and Sanne Gram-Nielsen and Kristensen, {Niels Rode} and Hanne Refsgaard",

year = "2018",

doi = "10.1155/2018/1205121",

language = "English",

volume = "2018",

journal = "Journal of Diabetes Research",

issn = "2314-6745",

publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Factors Affecting the Absorption of Subcutaneously Administered Insulin

T2 - Effect on Variability

AU - Gradel, Anna Katrina Jógvansdóttir

AU - Porsgaard, Trine

AU - Lykkesfeldt, Jens

AU - Seested, Torben

AU - Gram-Nielsen, Sanne

AU - Kristensen, Niels Rode

AU - Refsgaard, Hanne

PY - 2018

Y1 - 2018

N2 - Variability in the effect of subcutaneously administered insulin represents a major challenge in insulin therapy where precise dosing is required in order to achieve targeted glucose levels. Since this variability is largely influenced by the absorption of insulin, a deeper understanding of the factors affecting the absorption of insulin from the subcutaneous tissue is necessary in order to improve glycaemic control and the long-term prognosis in people with diabetes. These factors can be related to either the insulin preparation, the injection site/patient, or the injection technique. This review highlights the factors affecting insulin absorption with special attention on the physiological factors at the injection site. In addition, it also provides a detailed description of the insulin absorption process and the various modifications to this process that have been utilized by the different insulin preparations available.

AB - Variability in the effect of subcutaneously administered insulin represents a major challenge in insulin therapy where precise dosing is required in order to achieve targeted glucose levels. Since this variability is largely influenced by the absorption of insulin, a deeper understanding of the factors affecting the absorption of insulin from the subcutaneous tissue is necessary in order to improve glycaemic control and the long-term prognosis in people with diabetes. These factors can be related to either the insulin preparation, the injection site/patient, or the injection technique. This review highlights the factors affecting insulin absorption with special attention on the physiological factors at the injection site. In addition, it also provides a detailed description of the insulin absorption process and the various modifications to this process that have been utilized by the different insulin preparations available.

KW - Faculty of Health and Medical Sciences

U2 - 10.1155/2018/1205121

DO - 10.1155/2018/1205121

M3 - Review

C2 - 30116732

SN - 2314-6745

VL - 2018

JO - Journal of Diabetes Research

JF - Journal of Diabetes Research

M1 - 1205121

ER -

Factors Affecting the Absorption of Subcutaneously Administered Insulin: Effect on Variability

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this