Factors Affecting the Absorption of Subcutaneously Administered Insulin: Effect on Variability

TY - JOUR

T1 - Factors Affecting the Absorption of Subcutaneously Administered Insulin

T2 - Effect on Variability

AU - Gradel, Anna Katrina Jógvansdóttir

AU - Porsgaard, Trine

AU - Lykkesfeldt, Jens

AU - Seested, Torben

AU - Gram-Nielsen, Sanne

AU - Kristensen, Niels Rode

AU - Refsgaard, Hanne

PY - 2018

Y1 - 2018

N2 - Variability in the effect of subcutaneously administered insulin represents a major challenge in insulin therapy where precise dosing is required in order to achieve targeted glucose levels. Since this variability is largely influenced by the absorption of insulin, a deeper understanding of the factors affecting the absorption of insulin from the subcutaneous tissue is necessary in order to improve glycaemic control and the long-term prognosis in people with diabetes. These factors can be related to either the insulin preparation, the injection site/patient, or the injection technique. This review highlights the factors affecting insulin absorption with special attention on the physiological factors at the injection site. In addition, it also provides a detailed description of the insulin absorption process and the various modifications to this process that have been utilized by the different insulin preparations available.

AB - Variability in the effect of subcutaneously administered insulin represents a major challenge in insulin therapy where precise dosing is required in order to achieve targeted glucose levels. Since this variability is largely influenced by the absorption of insulin, a deeper understanding of the factors affecting the absorption of insulin from the subcutaneous tissue is necessary in order to improve glycaemic control and the long-term prognosis in people with diabetes. These factors can be related to either the insulin preparation, the injection site/patient, or the injection technique. This review highlights the factors affecting insulin absorption with special attention on the physiological factors at the injection site. In addition, it also provides a detailed description of the insulin absorption process and the various modifications to this process that have been utilized by the different insulin preparations available.

KW - Faculty of Health and Medical Sciences

U2 - 10.1155/2018/1205121

DO - 10.1155/2018/1205121

M3 - Review

C2 - 30116732

SN - 2314-6745

VL - 2018

JO - Journal of Diabetes Research

JF - Journal of Diabetes Research

M1 - 1205121

ER -