ERG Controls B Cell Development by Promoting Igh V-to-DJ Recombination

Elisabeth Søndergaard, Alexander Rauch, Magali Michaut, Nicolas Rapin, Matilda Rehn, Anna S. Wilhelmson, Alessandro Camponeschi, Marie S. Hasemann, Frederik O. Bagger, Johan Jendholm, Kasper J. Knudsen, Susanne Mandrup, Inga Lill Mårtensson, Bo T. Porse*

*Corresponding author af dette arbejde
3 Citationer (Scopus)

Abstract

Søndergaard et al. demonstrate that ERG is a critical transcriptional regulator essential for B cell development. Loss of ERG leads to a marked reduction in V-to-DJ recombination at the Igh locus, precluding B cell progenitors from expressing the pre-B cell receptor, which is required for entering the final stages of B cell development.

OriginalsprogEngelsk
TidsskriftCell Reports
Vol/bind29
Udgave nummer9
Sider (fra-til)2756-2769.e6
Antal sider21
ISSN2211-1247
DOI
StatusUdgivet - 26 nov. 2019

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