Adult Stromal (Skeletal, Mesenchymal) Stem Cells: Advances Towards Clinical Applications

Abbas Jafari Kermani; Linda Harkness; Walid Zaher; Moustapha Saad El-Deen Kassem

doi:10.1007/978-1-4614-9569-7_15

Adult Stromal (Skeletal, Mesenchymal) Stem Cells: Advances Towards Clinical Applications

Abbas Jafari Kermani, Linda Harkness, Walid Zaher, Moustapha Saad El-Deen Kassem

Morphogenesis and Differentiation Program

Abstract

Mesenchymal Stem Cells (MSC) are non-hematopoietic adult stromal cells that reside in a perivascular niche in close association with pericytes and endothelial cells and possess self-renewal and multi-lineage differentiation capacity. The origin, unique properties, and therapeutic benefits of MSC are under intensive investigation worldwide. Several challenges with regard to the proper source of clinical-grade MSC and the efficacy of MSC-based treatment strategies need to be addressed before MSC can be routinely used in the clinic. Here, we discuss three areas that can potentially facilitate the translation of MSC into clinic: Generation of MSC-like cells from human pluripotent stem cells, strategies to enhance homing of MSC to injured tissues, and targeting of MSC in vivo.

Original language	English
Title of host publication	Adult Stem Cells : Stem Cell Biology and Regenerative Medicine
Editors	Kursad Turksen
Number of pages	15
Place of Publication	New York
Publisher	Humana Press
Publication date	2014
Pages	359-373
ISBN (Print)	978-1-4614-9568-0
ISBN (Electronic)	978-1-4614-9569-7
DOIs	https://doi.org/10.1007/978-1-4614-9569-7_15
Publication status	Published - 2014

Keywords

Faculty of Health and Medical Sciences

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10.1007/978-1-4614-9569-7_15

http://link.springer.com/chapter/10.1007/978-1-4614-9569-7_15

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Adult Stromal (Skeletal, Mesenchymal) Stem Cells: Advances Towards Clinical Applications. / Kermani, Abbas Jafari; Harkness, Linda; Zaher, Walid et al.

Adult Stem Cells : Stem Cell Biology and Regenerative Medicine. ed. / Kursad Turksen. New York : Humana Press, 2014. p. 359-373.

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

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AB - Mesenchymal Stem Cells (MSC) are non-hematopoietic adult stromal cells that reside in a perivascular niche in close association with pericytes and endothelial cells and possess self-renewal and multi-lineage differentiation capacity. The origin, unique properties, and therapeutic benefits of MSC are under intensive investigation worldwide. Several challenges with regard to the proper source of clinical-grade MSC and the efficacy of MSC-based treatment strategies need to be addressed before MSC can be routinely used in the clinic. Here, we discuss three areas that can potentially facilitate the translation of MSC into clinic: Generation of MSC-like cells from human pluripotent stem cells, strategies to enhance homing of MSC to injured tissues, and targeting of MSC in vivo.

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Adult Stromal (Skeletal, Mesenchymal) Stem Cells: Advances Towards Clinical Applications

Abstract

Keywords

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