Adult Stromal (Skeletal, Mesenchymal) Stem Cells: Advances Towards Clinical Applications

Abbas Jafari Kermani; Linda Harkness; Walid Zaher; Moustapha Saad El-Deen Kassem

doi:10.1007/978-1-4614-9569-7_15

Adult Stromal (Skeletal, Mesenchymal) Stem Cells: Advances Towards Clinical Applications

Abbas Jafari Kermani, Linda Harkness, Walid Zaher, Moustapha Saad El-Deen Kassem

Morphogenesis and Differentiation Program

Abstract

Mesenchymal Stem Cells (MSC) are non-hematopoietic adult stromal cells that reside in a perivascular niche in close association with pericytes and endothelial cells and possess self-renewal and multi-lineage differentiation capacity. The origin, unique properties, and therapeutic benefits of MSC are under intensive investigation worldwide. Several challenges with regard to the proper source of clinical-grade MSC and the efficacy of MSC-based treatment strategies need to be addressed before MSC can be routinely used in the clinic. Here, we discuss three areas that can potentially facilitate the translation of MSC into clinic: Generation of MSC-like cells from human pluripotent stem cells, strategies to enhance homing of MSC to injured tissues, and targeting of MSC in vivo.

Originalsprog	Engelsk
Titel	Adult Stem Cells : Stem Cell Biology and Regenerative Medicine
Redaktører	Kursad Turksen
Antal sider	15
Udgivelsessted	New York
Forlag	Humana Press
Publikationsdato	2014
Sider	359-373
ISBN (Trykt)	978-1-4614-9568-0
ISBN (Elektronisk)	978-1-4614-9569-7
DOI	https://doi.org/10.1007/978-1-4614-9569-7_15
Status	Udgivet - 2014

Emneord

Det Sundhedsvidenskabelige Fakultet
Mesenchymal stem cells
MSC-like cells
Pluripotent stem cells
Homing
In vivo targeting

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10.1007/978-1-4614-9569-7_15

http://link.springer.com/chapter/10.1007/978-1-4614-9569-7_15

Citationsformater

Adult Stromal (Skeletal, Mesenchymal) Stem Cells: Advances Towards Clinical Applications. / Kermani, Abbas Jafari; Harkness, Linda; Zaher, Walid et al.

Adult Stem Cells : Stem Cell Biology and Regenerative Medicine. red. / Kursad Turksen. New York : Humana Press, 2014. s. 359-373.

Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › peer review

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AB - Mesenchymal Stem Cells (MSC) are non-hematopoietic adult stromal cells that reside in a perivascular niche in close association with pericytes and endothelial cells and possess self-renewal and multi-lineage differentiation capacity. The origin, unique properties, and therapeutic benefits of MSC are under intensive investigation worldwide. Several challenges with regard to the proper source of clinical-grade MSC and the efficacy of MSC-based treatment strategies need to be addressed before MSC can be routinely used in the clinic. Here, we discuss three areas that can potentially facilitate the translation of MSC into clinic: Generation of MSC-like cells from human pluripotent stem cells, strategies to enhance homing of MSC to injured tissues, and targeting of MSC in vivo.

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Adult Stromal (Skeletal, Mesenchymal) Stem Cells: Advances Towards Clinical Applications

Abstract

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