Thomas van Overeem Hansen

Research output

Research output per year 2004 2010 2013 2018

• 21 Journal article

Research output per year

Research output per year

Search results

• 2018

  MicroRNA dysregulation in adenoid cystic carcinoma of the salivary gland in relation to prognosis and gene fusion status: a cohort study

  Andreasen, S., Tan, Q., Agander, T. K., Hansen, T. V. O., Steiner, P., Bjørndal, K., Høgdall, E., Larsen, S. R., Erentaite, D., Olsen, C. H., Ulhøi, B. P., Heegaard, S., Wessel, I. & Homøe, P., Sept 2018, In: Virchows Archiv. 473, 3, p. 329-340

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Adenoid Cystic Carcinoma 100%
  • Gene Fusion 89%
  • Salivary Glands 81%
  • MicroRNAs 66%
  • Cohort Studies 53%
  12 Citations (Scopus)
• 2016

  Validation study of HPV DNA detection from stained FNA smears by polymerase chain reaction: Improving the diagnostic workup of patients with a tumor on the neck

  Channir, H. I., Larsen, C. G., Ahlborn, L. B., Hansen, T. V. O., Gerds, T. A., Charabi, B. W., Vainer, B., von Buchwald, C., Lajer, C. B. & Kiss, K., 1 Nov 2016, In: Cancer Cytopathology. 124, 11, p. 820-827 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Validation Studies 100%
  • Fine Needle Biopsy 92%
  • Neck 68%
  • Polymerase Chain Reaction 53%
  • DNA 50%
  13 Citations (Scopus)
• 2014

  IMP3 RNP safe houses prevent miRNA-directed HMGA2 mRNA decay in cancer and development

  Jønson, L., Christiansen, J., Hansen, T. V. O., Vikeså, J., Yamamoto, Y. & Nielsen, F. C., 24 Apr 2014, In: Cell Reports. 7, 2, p. 539-551 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ribonucleoproteins 100%
  • RNA Stability 89%
  • MicroRNAs 68%
  • Messenger RNA 46%
  • Neoplasms 26%
  49 Citations (Scopus)

  1360 Downloads (Pure)

• The genetic prehistory of the New World Arctic

  Raghavan, M., DeGiorgio, M., Albrechtsen, A., Moltke, I., Skoglund, P., Korneliussen, T. S., Grønnow, B., Appelt, M., Gulløv, H. C., Friesen, T. M., Fitzhugh, W., Malmström, H. S., Rasmussen, S., Olsen, J., Melchior, L. C., Fuller, B. T., Fahrni, S. M., Stafford jr., T., Grimes, V., Renouf, M. A. P., & 36 othersCybulski, J., Lynnerup, N., Lahr, M. M., Britton, K., Knecht, R., Arneborg, J., Metspalu, M., Cornejo, O. E., Malaspinas, A. S., Wang, Y., Rasmussen, M., Raghavan, V., Hansen, T. V. O., Khusnutdinova, E., Pierre, T. L., Dneprovsky, K., Andreasen, C., Lange, H., Hayes, M. G., Coltrain, J., Spitsyn, V. A., Götherström, A., Orlando, L. A. A., Kivisild, T., Villems, R., Crawford, M. H., Nielsen, F. C., Dissing, J., Heinemeier, J., Meldgaard, M., Bustamante, C., O'Rourke, D. H., Jakobsson, M., Gilbert, M. T. P., Nielsen, R. & Willerslev, E., 29 Aug 2014, In: Science. 345, 6200, 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Inuits 100%
  • Arctic Regions 81%
  • Archaeology 37%
  • Siberia 34%
  • Greenland 33%
  178 Citations (Scopus)
• 2013

  Classifications within molecular subtypes enables identification of BRCA1/BRCA2 mutation carriers by RNA tumor profiling

  Larsen, M. J., Kruse, T. A., Tan, Q., Lænkholm, A-V., Bak, M., Lykkesfeldt, A. E., Sørensen, K. P., Hansen, T. V. O., Ejlertsen, B., Gerdes, A-M. & Thomassen, M., 21 May 2013, In: P L o S One. 8, 5, 12 p., e64268.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Profiling 100%
  • RNA 85%
  • Tumor 75%
  • tumor 74%
  • Tumors 72%
  59 Citations (Scopus)

• Functional examination of MLH1, MSH2, and MSH6 intronic mutations identified in Danish colorectal cancer patients

  Petersen, S. M., Dandanell, M., Rasmussen, L. J., Gerdes, A-M., Krogh, L. N., Bernstein, I., Okkels, H., Wikman, F., Nielsen, F. C. & Hansen, T. V. O., 3 Oct 2013, In: BMC Medical Genetics. 14, p. 103

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Colorectal Neoplasms 100%
  • Mutation 70%
  • Computer Simulation 44%
  • Hereditary Nonpolyposis Colorectal Neoplasms 41%
  • Frameshift Mutation 19%
  16 Citations (Scopus)

• Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31

  Permuth-Wey, J., Lawrenson, K., Shen, H. C., Velkova, A., Tyrer, J. P., Chen, Z., Lin, H-Y., Chen, Y. A., Tsai, Y-Y., Qu, X., Ramus, S. J., Karevan, R., Lee, J., Lee, N., Larson, M. C., Aben, K. K., Anton-Culver, H., Antonenkova, N., Antoniou, A. C., Armasu, S. M., & 160 othersBacot, F., Baglietto, L., Bandera, E. V., Barnholtz-Sloan, J., Beckmann, M. W., Birrer, M. J., Bloom, G., Bogdanova, N., Brinton, L. A., Brooks-Wilson, A., Brown, R. J., Butzow, R., Cai, Q., Campbell, I., Chang-Claude, J., Chanock, S., Chenevix-Trench, G., Cheng, J. Q., Cicek, M. S., Coetzee, G. A., Cook, L. S., Couch, F. J., Cramer, D. W., Cunningham, J. M., Dansonka-Mieszkowska, A., Despierre, E., Doherty, J. A., Dörk, T., du Bois, A., Dürst, M., Easton, D. F., Eccles, D., Edwards, R., Ekici, A. B., Fasching, P. A., Fenstermacher, D. A., Flanagan, J. M., Garcia-Closas, M., Gentry-Maharaj, A., Giles, G. G., Glasspool, R. M., Gonzalez-Bosquet, J., Goodman, M. T., Gore, M., Górski, B., Gronwald, J., Hall, P., Halle, M. K., Harter, P., Heitz, F., Hillemanns, P., Hoatlin, M., Høgdall, C. K., Høgdall, E., Hosono, S., Jakubowska, A., Jensen, A., Jim, H., Kalli, K. R., Karlan, B. Y., Kaye, S. B., Kelemen, L. E., Kiemeney, L. A., Kikkawa, F., Konecny, G. E., Krakstad, C., Kjaer, S. K., Kupryjanczyk, J., Lambrechts, D., Lambrechts, S., Lancaster, J. M., Le, N. D., Leminen, A., Levine, D. A., Liang, D., Lim, B. K., Lin, J., Lissowska, J., Lu, K. H., Lubi?ski, J., Lurie, G., Massuger, L. F. A. G., Matsuo, K., McGuire, V., McLaughlin, J. R., Menon, U., Modugno, F., Moysich, K. B., Nakanishi, T., Narod, S. A., Nedergaard, L., Ness, R. B., Nevanlinna, H., Nickels, S., Noushmehr, H., Odunsi, K., Olson, S. H., Orlow, I., Paul, J., Pearce, C. L., Pejovic, T., Pelttari, L. M., Pike, M. C., Poole, E. M., Raska, P., Renner, S. P., Risch, H. A., Rodriguez-Rodriguez, L., Rossing, M. A., Rudolph, A., Runnebaum, I. B., Rzepecka, I. K., Salvesen, H. B., Schwaab, I., Severi, G., Shridhar, V., Shu, X-O., Shvetsov, Y. B., Sieh, W., Song, H., Southey, M. C., Spiewankiewicz, B., Stram, D., Sutphen, R., Teo, S-H., Terry, K. L., Tessier, D. C., Thompson, P. J., Tworoger, S. S., van Altena, A. M., Vergote, I., Vierkant, R. A., Vincent, D., Vitonis, A. F., Wang-Gohrke, S., Palmieri Weber, R., Wentzensen, N., Whittemore, A. S., Wik, E., Wilkens, L. R., Winterhoff, B., Woo, Y. L., Wu, A. H., Xiang, Y-B., Yang, H. P., Zheng, W., Ziogas, A., Zulkifli, F., Phelan, C. M., Iversen, E., Schildkraut, J. M., Berchuck, A., Fridley, B. L., Goode, E. L., Pharoah, P. D. P., Monteiro, A. N. A., Sellers, T. A., Gayther, S. A., Study, A. C. & Hansen, T. V. O., 2013, In: Nature Communications. 4, p. 1-12 1627.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • MicroRNA 100%
  • Ovarian Epithelial Carcinoma 94%
  • loci 91%
  • cancer 76%
  • Ovarian Neoplasms 74%
  79 Citations (Scopus)

• Von Hippel-Lindau disease (vHL)

  Binderup, M. L. M., Bisgaard, S. M. L., Harbud, V., Møller, H. U., Gimsing, S., Friis-Hansen, L., Hansen, T. V. O., Bagi, P., Knigge, U., Kosteljanetz, M., Bøgeskov, L., Thomsen, C., Gerdes, A-M., Ousager, L. B. & Sunde, L., Dec 2013, In: Danish Medical Journal. 60, 12, p. B4763

  Research output: Contribution to journal › Journal article › Research › peer-review

  • von Hippel-Lindau Disease 100%
  • Islet cell tumor syndrome 14%
  • Normetanephrine 13%
  • Metanephrine 12%
  • Hemangioblastoma 12%
  49 Citations (Scopus)
• 2012

  Functional characterization of MLH1 missense variants identified in Lynch Syndrome patients

  Andersen, S. D., Liberti, S. E., Lützen, A., Drost, M., Bernstein, I., Nilbert, M., Dominguez, M., Nyström, M., Hansen, T. V. O., Christoffersen, J. W., Jäger, A. C., de Wind, N., Nielsen, F. C., Tørring, P. M. & Rasmussen, L. J., Dec 2012, In: Human Mutation. 33, 12, p. 1647-1655 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hereditary Nonpolyposis Colorectal Neoplasms 100%
  • DNA Mismatch Repair 45%
  • Proteins 27%
  • exodeoxyribonuclease I 22%
  • Germ-Line Mutation 14%
  14 Citations (Scopus)
• 2011

  A method for detecting IBD regions simultaneously in multiple individuals--with applications to disease genetics

  Moltke, I., Albrechtsen, A., Hansen, T. V. O., Nielsen, F. C. & Nielsen, R., Jul 2011, In: Genome Research. 21, 7, p. 1168-80 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Inborn Genetic Diseases 100%
  • Pedigree 59%
  • Single Nucleotide Polymorphism 45%
  • Monte Carlo Method 38%
  • Inbreeding 38%
  34 Citations (Scopus)

• Genetic variation at 9p22.2 and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers

  Ramus, S. J., Kartsonaki, C., Gayther, S. A., Pharoah, P. D. P., Sinilnikova, O. M., Beesley, J., Chen, X., McGuffog, L., Healey, S., Couch, F. J., Wang, X., Fredericksen, Z., Peterlongo, P., Manoukian, S., Peissel, B., Zaffaroni, D., Roversi, G., Barile, M., Viel, A., Allavena, A., & 31 othersOttini, L., Papi, L., Gismondi, V., Capra, F., Radice, P., Greene, M. H., Mai, P. L., Andrulis, I. L., Glendon, G., Ozcelik, H., Thomassen, M., Gerdes, A-M., Kruse, T. A., Cruger, D., Jensen, U. B., Caligo, M. A., Olsson, H., Kristoffersson, U., Lindblom, A., Arver, B., Karlsson, P. W., Stenmark Askmalm, M., Borg, A., Neuhausen, S. L., Ding, Y. C., Nathanson, K. L., Domchek, S. M., Hansen, T. V. O., Jønson, L., Ejlertsen, B. & OCGN, 19 Jan 2011, In: National Cancer Institute. Journal (Print). 103, 2, p. 105-16 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Genetic Variation 100%
  • Ovarian Neoplasms 94%
  • Mutation 57%
  • Single Nucleotide Polymorphism 34%
  • Alleles 30%
  34 Citations (Scopus)
• 2010

  A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population

  Antoniou, A. C., Wang, X., Fredericksen, Z. S., McGuffog, L., Tarrell, R., Sinilnikova, O. M., Healey, S., Morrison, J., Kartsonaki, C., Lesnick, T., Ghoussaini, M., Barrowdale, D., Peock, S., Cook, M., Oliver, C., Frost, D., Eccles, D., Evans, D. G., Eeles, R., Izatt, L., & 31 othersChu, C., Douglas, F., Paterson, J., Stoppa-Lyonnet, D., Houdayer, C., Mazoyer, S., Giraud, S., Lasset, C., Remenieras, A., Caron, O., Hardouin, A., Berthet, P., Hogervorst, F. B. L., Rookus, M. A., Jager, A., van den Ouweland, A., Hoogerbrugge, N., van der Luijt, R. B., Meijers-Heijboer, H., Gómez García, E. B., Devilee, P., Vreeswijk, M. P. G., Lubinski, J., Jakubowska, A., Gronwald, J., Huzarski, T., Byrski, T., Gerdes, A-M., Hansen, T. V. O., Nielsen, F. C. & EMBRACE, 1 Oct 2010, In: Nature Genetics. 42, 10, p. 885-92 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hormones 100%
  • Breast Neoplasms 90%
  • Mutation 79%
  • Single Nucleotide Polymorphism 79%
  • Population 55%
  253 Citations (Scopus)

• Ancient human genome sequence of an extinct Palaeo-Eskimo

  Rasmussen, M., Li, Y., Lindgreen, S., Pedersen, J. S., Albrechtsen, A., Moltke, I., Metspalu, M., Metspalu, E., Kivisild, T., Gupta, R., Bertalan, M., Nielsen, K., Gilbert, T., Wang, Y., Raghavan, M., Campos, P., Kamp, H. L. M., Wilson, A. S., Gledhill, A., Tridico, S., & 32 othersBunce, M., Lorenzen, E., Binladen, J. K. M. A., Guo, X., Zhao, J., Zhang, X., Zhang, H., Li, Z., Chen, M., Orlando, L. A. A., Kristiansen, K., Bak, M., Tommerup, N., Bendixen, C., Pierre, T. L., Grønnow, B., Meldgaard, M., Andreasen, C., Fedorova, S. A., Osipova, L. P., Higham, T. F. G., Ramsey, C. B., Hansen, T. V. O., Nielsen, F. C., Crawford, M. H., Brunak, S., Sicheritz-Pontén, T., Villems, R., Nielsen, R., Krogh, A., Wang, J. & Willerslev, E., 11 Feb 2010, In: Nature. 463, 7282, p. 757-762 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Inuits 100%
  • Human Genome 70%
  • Single Nucleotide Polymorphism 56%
  • Genome 45%
  • Permafrost 41%
  485 Citations (Scopus)

• Common genetic variants and modification of penetrance of BRCA2-associated breast cancer

  Gaudet, M. M., Kirchhoff, T., Green, T., Vijai, J., Korn, J. M., Guiducci, C., Segrè, A. V., McGee, K., McGuffog, L., Kartsonaki, C., Morrison, J., Healey, S., Sinilnikova, O. M., Stoppa-Lyonnet, D., Mazoyer, S., Gauthier-Villars, M., Sobol, H., Longy, M., Frenay, M., GEMO Study Collaborators, & 31 othersHogervorst, F. B. L., Rookus, M. A., Collée, J. M., Hoogerbrugge, N., van Roozendaal, K. E. P., Piedmonte, M., Rubinstein, W., Nerenstone, S., Van Le, L., Blank, S. V., Caldés, T., de la Hoya, M., Nevanlinna, H., Aittomäki, K., Lazaro, C., Blanco, I., Arason, A., Johannsson, O. T., Barkardottir, R. B., Devilee, P., Olopade, O. I., Neuhausen, S. L., Wang, X., Fredericksen, Z. S., Peterlongo, P., Manoukian, S., Barile, M., Viel, A., Overeem Hansen, T. V., Nielsen, F. C. & HEBON Study Collaborators, 1 Oct 2010, In: P L o S Genetics. 6, 10, p. e1001183

  Research output: Contribution to journal › Journal article › Research › peer-review

  • penetrance 100%
  • Penetrance 86%
  • breast neoplasms 85%
  • mutation 74%
  • cancer 69%
  75 Citations (Scopus)

• Identification of a Danish breast/ovarian cancer family double heterozygote for BRCA1 and BRCA2 mutations

  Steffensen, A. Y., Jønson, L., Ejlertsen, B., Gerdes, A-M., Nielsen, F. C. & Hansen, T. V. O., 1 Sept 2010, In: Familial Cancer. 9, 3, p. 283-7 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Heterozygote 100%
  • Ovarian Neoplasms 85%
  • Breast Neoplasms 59%
  • Mutation 52%
  • Exons 17%
  13 Citations (Scopus)

• Identification of a novel BRCA1 nucleotide 4803delCC/c.4684delCC mutation and a nucleotide 249T>A/c.130T>A (p.Cys44Ser) mutation in two Greenlandic Inuit families: implications for genetic screening of Greenlandic Inuit families with high risk for breast and/or ovarian cancer

  Hansen, T. V. O., Jønson, L., Albrechtsen, A., Steffensen, A. Y., Bergsten, E. B., Myrhøj, T., Ejlertsen, B. L. & Nielsen, F. C., Nov 2010, In: Breast Cancer Research and Treatment. 124, 1, p. 259-264 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Inuits 100%
  • Genetic Testing 69%
  • Ovarian Neoplasms 61%
  • Nucleotides 54%
  • Breast Neoplasms 42%
  7 Citations (Scopus)
• 2009

  Large BRCA1 and BRCA2 genomic rearrangements in Danish high risk breast-ovarian cancer families

  Hansen, T. V. O., Jønson, L., Albrechtsen, A., Andersen, M. K., Ejlertsen, B. & Nielsen, F. C., May 2009, In: Breast Cancer Research and Treatment. 115, 2, p. 315-323 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ovarian Neoplasms 100%
  • Exons 91%
  • Breast Neoplasms 70%
  • Mutation 27%
  • Chromosomes, Human, Pair 17 15%
  46 Citations (Scopus)
• 2007

  Blau syndrome-associated mutations in exon 4 of the caspase activating recruitment domain 15 (CARD 15) gene are not found in ethnic Danes with sarcoidosis

  Milman, N., Nielsen, F. C., Hviid, T. V. F. & Hansen, T. V. O., Dec 2007, In: Clinical Respiratory Journal. 1, 2, p. 74-9 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Blau syndrome 100%
  • Caspase Activation and Recruitment Domain 85%
  • Sarcoidosis 62%
  • Exons 47%
  • Mutation 32%
  6 Citations (Scopus)
• 2006

  Favourable effect of TNF-alpha inhibitor (infliximab) on Blau syndrome in monozygotic twins with a de novo CARD15 mutation

  Milman, N., Andersen, C. B., Hansen, A., van Overeem Hansen, T., Nielsen, F. C., Fledelius, H., Ahrens, P. & Nielsen, O. H., Dec 2006, In: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 114, 12, p. 912-9 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Blau syndrome 100%
  • Tumor Necrosis Factor Inhibitors 69%
  • Monozygotic Twins 68%
  • Infliximab 67%
  • Tumor Necrosis Factor-alpha 40%
  71 Citations (Scopus)
• 2005

  Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer

  Hammer, N. A., Hansen, T. V. O., Byskov, A. G., Rajpert-De Meyts, E., Grøndahl, M. L., Bredkjaer, H. E., Wewer, U. M., Christiansen, J. & Nielsen, F. C., 2005, In: Reproduction. 130, 2, p. 203-12 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Insulin-Like Growth Factor II 100%
  • Gonads 92%
  • Testicular Neoplasms 91%
  • Carrier Proteins 67%
  • Messenger RNA 45%
  85 Citations (Scopus)
• 2004

  Dwarfism and impaired gut development in insulin-like growth factor II mRNA-binding protein 1-deficient mice

  Hansen, T. V. O., Hammer, N. A., Nielsen, J., Madsen, M., Dalbaeck, C., Wewer, U. M., Christiansen, J. & Nielsen, F. C., 2004, In: Molecular and Cellular Biology. 24, 10, p. 4448-64 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Dwarfism 100%
  • Insulin-Like Growth Factor II 90%
  • Carrier Proteins 61%
  • Messenger RNA 41%
  • Procollagen 21%
  158 Citations (Scopus)