Thomas Andrew Qvistgaard Jepps

Research output

Research output per year 2009 2014 2016 2018 2019 2020

• 28 Journal article
• 1 Review

Research output per year

Research output per year

Search results

• 2020

  Effects of a novel selenium substituted-sugar (1,4-anhydro-4-seleno-d-talitol, SeTal) on human coronary artery cell lines and mouse aortic rings

  Zacharias, T., Flouda, K., Jepps, T. A., Gammelgaard, B., Schiesser, C. H. & Davies, M. J., Mar 2020, In: Biochemical Pharmacology. p. 113631

  Research output: Contribution to journal › Journal article › Research › peer-review

  • altritol 100%
  • Protective Agent 65%
  • Selenium 51%
  • Bioavailability 45%
  • Sugars 45%
  2 Citations (Scopus)

• Genome-wide association study identifies locus at chromosome 2q32.1 associated with syncope and collapse

  Hadji-Turdeghal, K., Andreasen, L., Hagen, C. M., Ahlberg, G., Ghouse, J., Bækvad-Hansen, M., Bybjerg-Grauholm, J., Hougaard, D. M., Hedley, P., Haunsø, S., Svendsen, J. H., Kanters, J. K., Jepps, T. A., Skov, M. W., Christiansen, M. & Olesen, M. S., 1 Jan 2020, In: Cardiovascular Research.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Syncope 100%
  • Genome-Wide Association Study 95%
  • Chromosomes 72%
  • Zinc Fingers 25%
  • Genome 23%
  3 Citations (Scopus)
• 2019

  Deletion in mice of X-linked, Brugada syndrome- and atrial fibrillation-associated Kcne5 augments ventricular KV currents and predisposes to ventricular arrhythmia

  David, J-P., Lisewski, U., Crump, S. M., Jepps, T. A., Bocksteins, E., Wilck, N., Lossie, J., Roepke, T. K., Schmitt, N. & Abbott, G. W., Feb 2019, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 2, p. 2537-2552 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Brugada Syndrome 100%
  • Intracardiac 65%
  • Atrial Fibrillation 64%
  • Cardiac Arrhythmias 61%
  • Mutation 61%
  7 Citations (Scopus)

• Kcne4 deletion sex dependently inhibits the RISK pathway response and exacerbates hepatic ischemia-reperfusion injury in mice

  Hu, Z., Jepps, T. A., Zhou, L., Liu, J., Li, M. & Abbott, G. W., 1 May 2019, In: A J P: Regulatory, Integrative and Comparative Physiology (Online). 316, 5, p. R552-R562

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Reperfusion Injury 100%
  • Phosphotransferases 79%
  • Liver 53%
  • Survivors 37%
  • Glycogen Synthase Kinase 3 34%

• KCNQ5 activation is a unifying molecular mechanism shared by genetically and culturally diverse botanical hypotensive folk medicines

  Manville, R. W., van der Horst, J., Redford, K. E., Katz, B. B., Jepps, T. A. & Abbott, G. W., 15 Oct 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 42, p. 21236-21245

  Research output: Contribution to journal › Journal article › Research › peer-review

  15 Citations (Scopus)

• TMEM16A is implicated in the regulation of coronary flow and is altered in hypertension

  Askew Page, H. R., Dalsgaard, T., Baldwin, S. N., Jepps, T. A., Povstyan, O., Olesen, S. P. & Greenwood, I. A., Jun 2019, In: British Journal of Pharmacology. 176, 11, p. 1635-1648

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Coronary Vessels 100%
  • 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid 81%
  • Hypertension 79%
  • Inbred SHR Rats 66%
  • T16AInh-A01 61%
  11 Citations (Scopus)
• 2018

  4-Aminopyridine: a pan voltage-gated potassium channel inhibitor that enhances K7.4 currents and inhibits noradrenaline-mediated contraction of rat mesenteric small arteries

  Khammy, M. M., Kim, S., Bentzen, B. H., Lee, S., Choi, I., Aalkjaer, C. & Jepps, T. A., Feb 2018, In: British Journal of Pharmacology. 175, 3, p. 501-516 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Voltage-Gated Potassium Channels 100%
  • 4-Aminopyridine 97%
  • Mesenteric Arteries 92%
  • Norepinephrine 64%
  • Oocytes 11%
  10 Citations (Scopus)

• Angiotensin II Promotes K_V7.4 Channels Degradation Through Reduced Interaction With HSP90 (Heat Shock Protein 90)

  Barrese, V., Stott, J. B., Figueiredo, H. B., Aubdool, A. A., Hobbs, A. J., Jepps, T. A., McNeish, A. J. & Greenwood, I. A., Jun 2018, In: Hypertension. 71, 6, p. 1091-1100 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • HSP90 Heat-Shock Proteins 100%
  • Angiotensin II 73%
  • Vascular Smooth Muscle 24%
  • Smooth Muscle Myocytes 22%
  • Ubiquitination 18%
  8 Citations (Scopus)

• Contractile responses in intact and mucosa-denuded human ureter: a comparison with urinary bladder detrusor preparations

  Roedel, M., Ravens, U., Kasper, M., Wirth, M. P., Jepps, T. A. & Propping, S., 1 Aug 2018, In: Naunyn-Schmiedeberg's Archives of Pharmacology. 391, 8, p. 773-782 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ureter 100%
  • Urinary Bladder 75%
  • Mucous Membrane 74%
  • Desmin 18%
  • Carbachol 17%
  4 Citations (Scopus)

• Impaired Kv7 channel function in cerebral arteries of a tauopathy mouse model (rTg4510)

  de Jong, I. E. M. & Jepps, T. A., Dec 2018, In: Physiological Reports. 6, 23, 10 p., e13920 .

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Tauopathies 100%
  • Cerebral Arteries 89%
  • HEK293 Cells 19%
  • Alzheimer Disease 14%
  • Myography 13%
  3 Citations (Scopus)

  56 Downloads (Pure)

• Microtubule Regulation of Kv7 Channels Orchestrates cAMP-Mediated Vasorelaxations in Rat Arterial Smooth Muscle

  Lindman, J., Khammy, M. M., Lundegaard, P. R., Aalkjær, C. & Jepps, T. A., Feb 2018, In: Hypertension. 71, 2, p. 336-345 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Mesenteric Arteries 100%
  • Microtubules 79%
  • Vasodilation 78%
  • Colchicine 78%
  • Smooth Muscle 71%
  7 Citations (Scopus)
• 2017

  Unravelling the complexities of vascular smooth muscle ion channels: Fine tuning of activity by ancillary subunits

  Jepps, T. A., Oct 2017, In: Pharmacology & Therapeutics. 178, p. 57-66 10 p.

  Research output: Contribution to journal › Review › peer-review

  • Ion Channels 100%
  • Vascular Smooth Muscle 99%
  • Vascular Diseases 49%
  • Membrane Potentials 24%
  • Epidemics 21%
  3 Citations (Scopus)
• 2016

  Kcne4 Deletion Sex-Dependently Alters Vascular Reactivity

  Abbott, G. W. & Jepps, T. A., 1 Dec 2016, In: Journal of Vascular Research. 53, 3-4, p. 138-148 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Mesenteric Arteries 100%
  • Blood Vessels 80%
  • Methoxamine 38%
  • Voltage-Gated Potassium Channels 35%
  • Isoproterenol 27%
  20 Citations (Scopus)

• MicroRNA-153 targeting of KCNQ4 contributes to vascular dysfunction in hypertension

  Carr, G., Barrese, V., Stott, J. B., Povstyan, O. V., Jepps, T. A., Figueiredo, H. B., Zheng, D., Jamshidi, Y. & Greenwood, I. A., 1 Nov 2016, In: Cardiovascular Research. 112, p. 581-589 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • rat Kcnq4 protein 100%
  • MicroRNAs 98%
  • Mesenteric Arteries 94%
  • 3' Untranslated Regions 80%
  • Hypertension 75%
  27 Citations (Scopus)

  154 Downloads (Pure)

• Molecular and functional characterization of Kv 7 channels in penile arteries and corpus cavernosum of healthy and metabolic syndrome rats

  Jepps, T. A., Olesen, S. P., Greenwood, I. A. & Dalsgaard, T., 1 May 2016, In: British Journal of Pharmacology. 173, 9, p. 1478-1490 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Metabolic Syndrome 100%
  • Arteries 80%
  • BMS204352 63%
  • Heart Failure 56%
  • linopirdine 56%
  21 Citations (Scopus)

• pH-dependent inhibition of K2P3.1 prolongs atrial refractoriness in whole hearts

  Skarsfeldt, M. A., Jepps, T. A., Bomholtz, S. H., Abildgaard, L., Sørensen, U. S., Gregers, E., Svendsen, J. H., Diness, J. G., Grunnet, M., Schmitt, N., Olesen, S-P. & Bentzen, B. H., 1 Apr 2016, In: Pfluegers Archiv. 468, 4, p. 643-654 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Refractory 100%
  • Antiarrhythmic Agent 79%
  • Heart 62%
  • Action Potentials 49%
  • Atrial Fibrillation 48%
  8 Citations (Scopus)
• 2015

  Contribution of Kv7 channels to natriuretic peptide mediated vasodilation in normal and hypertensive rats

  Stott, J. B., Barrese, V., Jepps, T. A., Leighton, E. V. & Greenwood, I. A., 4 Mar 2015, In: Hypertension. 65, 3, p. 676-82 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Natriuretic Peptides 100%
  • Vasodilation 77%
  • linopirdine 72%
  • Vasodilator Agents 61%
  • Atrial Natriuretic Factor 44%
  38 Citations (Scopus)

• Fundamental role for the KCNE4 ancillary subunit in Kv7.4 regulation of arterial tone

  Jepps, T. A., Carr, G., Lundegaard, P. R., Olesen, S-P. & Greenwood, I. A., 15 Dec 2015, In: Journal of Physiology. 593, 24, p. 5325-40 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Mesenteric Arteries 100%
  • Muscle Cells 37%
  • Membranes 36%
  • Arteries 30%
  • Methoxamine 28%
  43 Citations (Scopus)
• 2014

  Contribution of kv7.4/kv7.5 heteromers to intrinsic and calcitonin gene-related Peptide-induced cerebral reactivity

  Chadha, P. S., Jepps, T. A., Carr, G., Stott, J. B., Zhu, H-L., Cole, W. C. & Greenwood, I. A., Apr 2014, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 34, 4, p. 887-93 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Calcitonin Gene-Related Peptide 100%
  • Middle Cerebral Artery 92%
  • Vasodilation 49%
  • Arteries 38%
  • linopirdine 30%
  57 Citations (Scopus)

• KV7 potassium channels: a new therapeutic target in smooth muscle disorders

  Stott, J. B., Jepps, T. A. & Greenwood, I. A., Apr 2014, In: Drug Discovery Today. 19, 4, p. 413-424 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Potassium Channels 100%
  • Muscular Diseases 94%
  • Smooth Muscle 76%
  • Disorder 74%
  • Voltage-Gated Potassium Channels 23%
  64 Citations (Scopus)

• Vasorelaxant effects of novel Kv7.4 channel enhancers ML213 and NS15370

  Jepps, T. A., Bentzen, B. H., Stott, J. B., Povstyan, O. V., Sivaloganathan, K., Dalby-Brown, W. & Greenwood, I. A., 1 Oct 2014, In: British Journal of Pharmacology. 171, 19, p. 4413-4424 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • 2-(3,5-difluorophenyl)-N-(6-((4-fluorophenyl)methylamino)-2-morpholino-3-pyridyl)acetamide 100%
  • Vasodilator Agents 40%
  • Mesenteric Arteries 36%
  • BMS204352 20%
  • Blood Vessels 17%
  31 Citations (Scopus)
• 2013

  Contribution of KV7 Channels to Basal Coronary Flow and Active Response to Ischemia

  Khanamiri, S., Soltysinska, E., Jepps, T. A., Bentzen, B. H., Chadha, P. S., Schmitt, N., Greenwood, I. A. & Olesen, S-P., 30 Sept 2013, In: Hypertension. 62, 6, p. 1090-1097 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ischemia 100%
  • Coronary Vessels 54%
  • 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine 33%
  • Adenosine A2A Receptors 30%
  • Isolated Heart Preparation 29%
  58 Citations (Scopus)

• One man's side effect is another man's therapeutic opportunity: targeting Kv7 channels in smooth muscle disorders

  Jepps, T. A., Olesen, S. P. & Greenwood, I. A., Jan 2013, In: British Journal of Pharmacology. 168, 1, p. 19-27 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • ezogabine 100%
  • Muscular Diseases 65%
  • Smooth Muscle 53%
  • Premature Obstetric Labor 35%
  • Constipation 31%
  34 Citations (Scopus)
• 2012

  Pharmacological dissection of K(v)7.1 channels in systemic and pulmonary arteries

  Chadha, P. S., Zunke, F., Davis, A. J., Jepps, T. A., Linders, J. T. M., Schwake, M., Towart, R. & Greenwood, I. A., Jun 2012, In: British Journal of Pharmacology. 166, 4, p. 1377-87 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • L 768673 100%
  • Pulmonary Artery 62%
  • Dissection 58%
  • Mesenteric Arteries 55%
  • Arteries 50%
  35 Citations (Scopus)

• Reduced KCNQ4-encoded voltage-dependent potassium channel activity underlies impaired ß-adrenoceptor-mediated relaxation of renal arteries in hypertension

  Chadha, P. S., Zunke, F., Zhu, H-L., Davis, A. J., Jepps, T. A., Olesen, S-P., Cole, W. C., Moffatt, J. D. & Greenwood, I., Apr 2012, In: Hypertension. 59, 4, p. 877-84 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Potassium Channels 100%
  • Renal Artery 93%
  • Isoproterenol 88%
  • Adrenergic Receptors 83%
  • Inbred SHR Rats 71%
  78 Citations (Scopus)
• 2011

  Downregulation of Kv7.4 channel activity in primary and secondary hypertension

  Jepps, T. A., Chadha, P. S., Davis, A. J., Harhun, M. I., Cockerill, G. W., Olesen, S. P., Hansen, R. S. & Greenwood, I. A., 2 Aug 2011, In: Circulation. 124, 5, p. 602-11 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • BMS204352 100%
  • ezogabine 80%
  • Mesenteric Arteries 79%
  • Inbred SHR Rats 53%
  • Down-Regulation 45%
  100 Citations (Scopus)

• Expression and function of the K+ channel KCNQ genes in human arteries

  Ng, F. L., Davis, A. J., Jepps, T. A., Harhun, M. I., Yeung, S. Y., Wan, A., Reddy, M., Melville, D., Nardi, A., Khong, T. K. & Greenwood, I. A., Jan 2011, In: British Journal of Pharmacology. 162, 1, p. 42-53 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Arteries 100%
  • Genes 54%
  • 6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane 35%
  • linopirdine 34%
  • Blood Vessels 33%
  99 Citations (Scopus)
• 2010

  Expression profile and protein translation of TMEM16A in murine smooth muscle

  Davis, A. J., Forrest, A. S., Jepps, T. A., Valencik, M. L., Wiwchar, M., Singer, C. A., Sones, W. R., Greenwood, I. A. & Leblanc, N., Nov 2010, In: A J P: Cell Physiology (Online). 299, 5, p. C948-59

  Research output: Contribution to journal › Journal article › Research

  • Protein Biosynthesis 100%
  • Portal Vein 93%
  • Anoctamin-1 80%
  • Smooth Muscle 80%
  • Green Fluorescent Proteins 73%
  91 Citations (Scopus)
• 2009

  Molecular and functional characterization of Kv7 K+ channel in murine gastrointestinal smooth muscles

  Jepps, T. A., Greenwood, I. A., Moffatt, J. D., Sanders, K. M. & Ohya, S., Jul 2009, In: A J P: Gastrointestinal and Liver Physiology (Online). 297, 1, p. G107-15

  Research output: Contribution to journal › Journal article › Research

  • Smooth Muscle 100%
  • Gastrointestinal Tract 98%
  • Colon 91%
  • 6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane 69%
  • linopirdine 68%
  54 Citations (Scopus)