KV7 potassium channels: a new therapeutic target in smooth muscle disorders

TY - JOUR

T1 - KV7 potassium channels

T2 - a new therapeutic target in smooth muscle disorders

AU - Stott, Jennifer B

AU - Jepps, Thomas Andrew

AU - Greenwood, Iain A

N1 - Copyright © 2013. Published by Elsevier Ltd.

PY - 2014/4

Y1 - 2014/4

N2 - Potassium channels are key regulators of smooth muscle tone, with increases in activity resulting in hyperpolarisation of the cell membrane, which acts to oppose vasoconstriction. Several potassium channels exist within smooth muscle, but the KV7 family of voltage-gated potassium channels have been identified as being crucial mediators of this process in a variety of smooth muscle. Recently, KV7 channels have been shown to be involved in the pathogenesis of hypertension, as well as being implicated in other smooth muscle disorders, providing a new and inviting target for smooth muscle disorders.

AB - Potassium channels are key regulators of smooth muscle tone, with increases in activity resulting in hyperpolarisation of the cell membrane, which acts to oppose vasoconstriction. Several potassium channels exist within smooth muscle, but the KV7 family of voltage-gated potassium channels have been identified as being crucial mediators of this process in a variety of smooth muscle. Recently, KV7 channels have been shown to be involved in the pathogenesis of hypertension, as well as being implicated in other smooth muscle disorders, providing a new and inviting target for smooth muscle disorders.

U2 - 10.1016/j.drudis.2013.12.003

DO - 10.1016/j.drudis.2013.12.003

M3 - Journal article

C2 - 24333708

SN - 1359-6446

VL - 19

SP - 413

EP - 424

JO - Drug Discovery Today

JF - Drug Discovery Today

IS - 4

ER -