TY - JOUR
T1 - One man's side effect is another man's therapeutic opportunity
T2 - targeting Kv7 channels in smooth muscle disorders
AU - Jepps, Thomas Andrew
AU - Olesen, S P
AU - Greenwood, I A
N1 - © 2012 The Authors. British Journal of Pharmacology © 2012 The British Pharmacological Society.
PY - 2013/1
Y1 - 2013/1
N2 - Retigabine is a first in class anticonvulsant that has recently undergone clinical trials to test its efficacy in epileptic patients. Retigabine's novel mechanism of action - activating Kv7 channels - suppresses neuronal activity to prevent seizure generation by hyperpolarizing the membrane potential and suppressing depolarizing surges. However, Kv7 channels are not expressed exclusively in neurones and data generated over the last decade have shown that Kv7 channels play a key role in various smooth muscle systems of the body. This review discusses the potential of targeting Kv7 channels in the smooth muscle to treat diseases such as hypertension, bladder instability, constipation and preterm labour.
AB - Retigabine is a first in class anticonvulsant that has recently undergone clinical trials to test its efficacy in epileptic patients. Retigabine's novel mechanism of action - activating Kv7 channels - suppresses neuronal activity to prevent seizure generation by hyperpolarizing the membrane potential and suppressing depolarizing surges. However, Kv7 channels are not expressed exclusively in neurones and data generated over the last decade have shown that Kv7 channels play a key role in various smooth muscle systems of the body. This review discusses the potential of targeting Kv7 channels in the smooth muscle to treat diseases such as hypertension, bladder instability, constipation and preterm labour.
U2 - 10.1111/j.1476-5381.2012.02133.x
DO - 10.1111/j.1476-5381.2012.02133.x
M3 - Journal article
C2 - 22880633
SN - 0007-1188
VL - 168
SP - 19
EP - 27
JO - British Journal of Pharmacology
JF - British Journal of Pharmacology
IS - 1
ER -