Sven Frøkjær

2004

Effects of sucrose on rFVIIa aggregation and methionine oxidation

Soenderkaer, S., Carpenter, J. F., van de Weert, M., Hansen, L. L., Flink, J. & Frokjaer, S., Apr 2004, In: European Journal of Pharmaceutical Sciences. 21, 5, p. 597-606 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

27 Citations (Scopus)

Epidermal growth factor decreases PEPT2 transport capacity and expression in the rat kidney proximal tubule cell line SKPT0193 cl.2

Bravo, S. A., Nielsen, C. U., Amstrup, J., Frokjaer, S. & Brodin, B., 2004, In: American Journal of Physiology - Renal Physiology. 286, 2, p. 385-393

Research output: Contribution to journal › Journal article › Research › peer-review

18 Citations (Scopus)

Formulation, stability and characterization of protein and peptide drugs

Frøkjær, S., Hovgaard, L. & van de Weert, M., 2004, Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids. Mahato, R. I. (ed.). Boca Raton: CRC Press, p. 378-401

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication

5 Citations (Scopus)

In-depth evaluation of Gly-Sar transport parameters as a function of culture time in the Caco-2 cell model

Bravo, S. A., Nielsen, C. U., Amstrup, J., Frokjaer, S. & Brodin, B., 1 Jan 2004, In: European Journal of Pharmaceutical Sciences. 21, 1, p. 77-86 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

28 Citations (Scopus)

Interaction of dendritic cells with antigen-containing liposomes: effect of bilayer composition

Foged, C., Arigita, C., Sundblad, A., Jiskoot, W., Storm, G. & Frøkjær, S., 2004, In: Vaccine. 22, 15-16, p. 1903-13 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

144 Citations (Scopus)

Intestinal solute carriers: an overview of trends and strategies for improving oral drug absorption

Steffansen, B., Nielsen, C. U., Brodin, B., Eriksson, A. H., Andersen, R. & Frokjaer, S., 2004, In: European Journal of Pharmaceutical Sciences. 21, 1, p. 3-16 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

109 Citations (Scopus)

In vitro release of insulin aspart incorporated into water-in-oil emulsions

Jørgensen, L., Vermehren, C., Bjerregaard, S. & Frøkjær, S., 2004, In: Journal of Drug Delivery Science and Technology. 14, 6, p. 455-459

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

Micropipette manipulation a technique to evaluate the stability of water-in-oil emulsions containing proteins

Jørgensen, L., Kim, D. H., Vermehren, C., Bjerregaard, S. & Frøkjær, S., 2004, In: Journal of Pharmaceutical Sciences. 93, 12, p. 2994-3003

Research output: Contribution to journal › Journal article › Research › peer-review

14 Citations (Scopus)

Probing structural changes of proteins incorporated into water-in-oil emulsions

Jorgensen, L., van de Weert, M., Vermehren, C., Bjerregaard, S. & Frokjaer, S., Jul 2004, In: Journal of Pharmaceutical Sciences. 93, 7, p. 1847-59 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

40 Citations (Scopus)

2003

Erratum: Prodrugs of purine and pyrimidine analogues for the intestinal di/tri-peptide transporter PepT1: Affinity for hPepT1 in Caco-2 cells, drug release in aqueous media and in vitro metabolism (Journal of Controlled Release (2003) 86 (279-292) PII: S0168365902004133)

Thomsen, A. E., Friedrichsen, G. M., Sørensen, A. H., Andersen, R., Nielsen, C. U., Brodin, B., Begtrup, M., Frokjaer, S. & Steffansen, B., 7 Mar 2003, In: Journal of Controlled Release. 88, 2

Research output: Contribution to journal › Journal article › Research › peer-review

1 Citation (Scopus)

In vitro and in vivo aspects of N-acyl-phosphatidylethanolamine-containing liposomes

Vermehren, C., Clausen-Beck, B., Frøkjær, S. & Hansen, H. S., 18 Mar 2003, In: International Journal of Pharmaceutics. 254, 1, p. 49-53 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Prodrugs

Steffansen, B., Thomsen, A. E. & Frøkjær, S., 2003, Estimation of solubility, permeability, absorption and bioavaibility. van de Waterbeemd, H., Lennernäs, H. & Artursson, P. (eds.). Weinheim: Wiley-VCH, p. 532-546

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

Prodrugs of purine and pyrimidine analogues for the intestinal di/tri-peptide transporter PepT1: affinity for hPepT1 in Caco-2 cells, drug release in aqueous media and in vitro metabolism

Thomsen, A. E., Friedrichsen, G. M., Sørensen, A. H., Andersen, R., Nielsen, C. U., Brodin, B., Begtrup, M., Frokjaer, S. & Steffansen, B., 2003, In: Journal of Controlled Release. 86, 2-3, p. 279-92 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

27 Citations (Scopus)

Secondary structure alteration in insulin and growth hormone water-in-oil emulsions

Jørgensen, L., Vermehren, C., Bjerregaard, S. & Frøkjær, S., 2003, In: Internation Journal of Pharmaceutics. 254, 1, p. 7-10

Research output: Contribution to journal › Journal article › Research › peer-review

45 Citations (Scopus)

2002

A calorimetric study of phosphocholine membranes mixed with desmopressin and its diacylated prodrug derivative (DPP)

Pedersen, T. B., Frokjaer, S., Mouritsen, O. G. & Jørgensen, K., 21 Feb 2002, In: International Journal of Pharmaceutics. 233, 1-2, p. 199-206 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

Human peptide transporters: Therapeutic applications

Nielsen, C. U., Brodin, B., Jørgensen, F. S., Frokjaer, S. & Steffansen, B., 1 Sept 2002, In: Expert Opinion on Therapeutic Patents. 12, 9, p. 1329-1350 22 p.

Research output: Contribution to journal › Journal article › Research › peer-review

44 Citations (Scopus)

Transport characteristics of L-carnosine and the anticancer derivative 4-toluenesulfonylureido-carnosine in a human epithelial cell line

Nielsen, C. U., Supuran, C. T., Scozzafava, A., Frokjaer, S., Steffansen, B. & Brodin, B., 2002, In: Pharmaceutical Research. 19, 9, p. 1337-44 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

31 Citations (Scopus)

Transport of peptidomimetic drugs by the intestinal Di/tri-peptide transporter, PepT1

Brodin, B., Nielsen, C. U., Steffansen, B. & Frøkjaer, S., 2002, In: Basic & Clinical Pharmacology & Toxicology. 90, 6, p. 285-96 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

99 Citations (Scopus)

2001

Association of an acylated model peptide with DPPC-DPPS lipid membranes

Pedersen, T. B., Sabra, M. C., Frokjaer, S., Mouritsen, O. G. & Jørgensen, K., 19 Feb 2001, In: International Journal of Pharmaceutics. 214, 1-2, p. 77-81 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

Dipeptide model prodrugs for the intestinal oligopeptide transporter. Affinity for and transport via hPepT1 in the human intestinal Caco-2 cell line

Nielsen, C. U., Andersen, R., Brodin, B., Frokjaer, S., Taub, M. E. & Steffansen, B., 2001, In: Journal of Controlled Release. 76, 1-2, p. 129-38 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

65 Citations (Scopus)

Drug delivery by phospholipase A₂ degradable liposomes

Davidsen, J., Vermehren, C., Frokjaer, S., Mouritsen, O. G. & Jørgensen, K., 19 Feb 2001, In: International Journal of Pharmaceutics. 214, 1-2, p. 67-69 3 p.

Research output: Contribution to journal › Journal article › Research › peer-review

39 Citations (Scopus)

Epidermal growth factor inhibits glycylsarcosine transport and hPepT1 expression in a human intestinal cell line

Nielsen, C. U., Amstrup, J., Steffansen, B., Frokjaer, S. & Brodin, B., 2001, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 281, 1, p. G191-9

Research output: Contribution to journal › Journal article › Research › peer-review

90 Citations (Scopus)

Model prodrugs for the intestinal oligopeptide transporter: model drug release in aqueous solution and in various biological media

Nielsen, C. U., Andersen, R., Brodin, B., Frokjaer, S. & Steffansen, B., 2001, In: Journal of Controlled Release. 73, 1, p. 21-30 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

19 Citations (Scopus)

2000

Stability and vitro metabolism of dipeptide model prodrugs with affinity for the oligopeptide transporter

Lepist, E.-V., Steffansen, B., Kusk, T., Larsen, D. H., Andersen, D., Frøkjær, S., Taub, M. E., Veski, P. & Lennernas, H., 2000, In: European Journal of Pharmaceutical Sciences. 11, p. 43-50 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

14 Citations (Scopus)

1999

Stability metabolism and transport of D-Asp(OBzl)Ala -a model prodrug with affinity for the oligopeptide transporter

Steffansen, B., Lepist, E.-I., Frøkjær, S., Taub, M. E. & Lennernas, H., 1999, In: European Journal of Pharmaceutical Sciences. 8, p. 67-73

Research output: Contribution to journal › Journal article › Research › peer-review

20 Citations (Scopus)

1998

Assessment of side-chain modified dipeptides that interact with the oligopeptide transporter

Frøkjær, S., Steffansen, B. & Taub, M. E., 1998, Peptide and Protein Drug Delivery: Alfred Benzon Symposium 43. Munkgaard, p. 287-297 10 p.

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Oligopeptide transporter mediated uptake and transport of D-Asp(OBzl)-Ala, D-Glu(OBzl)-Ala and D-Ser(Bzl)-Ala in filter grown Caco-2 monolayers

Taub, M. E., Moss, B. A., Steffansen, B. & Frøkjær, S., 1998, In: International Journal of Pharmaceutics. 174, p. 223-232 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

18 Citations (Scopus)

Peptide and protein drug delivery : proceedings of a symposium held at the Royal Danish Academy of Sciences and Letters, August 17-21, 1997: Alfred Benzon Symposium, 43

Frøkjær, S., Christrup, L. L., Krogsgaard-Larsen, P. & Alfred Benzon, F., 1998, Copenhagen: Munksgaard .

Research output: Book/Report › Book › Research

1997

Beta-carboxylic acid esterfied D-Asp-Ala retains a high affinity for the oligopeptide transporter in Caco-2 cell monolayers

Taub, M. E., Larsen, B. D., Steffansen, B. & Frøkjær, S., 1997, In: International Journal of Pharmaceutics. 146, p. 205-212 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

Influence of oligopeptide transporter binding affinity upon uptake and transport of D-Asp(Obzl)-Ala and Asp(OBzl)-Sar in filter-grown Caco-2 monolayers

Taub, M. E., Moss, B. A., Steffansen, B. & Frøkjær, S., 1997, In: International Journal of Pharmaceutics. 156, p. 219-228 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

The effect of beta-turn structure on the permeation of peptides across monolayers of bovine brain microvessel endothelial cells

Sørensen, M., Steenberg, B., Knipp, G., Wang, W., Steffansen, B., Frøkjær, S. & Borchardt, R. T., 1997, In: Pharmaceutical Research. 14, p. 1341-1348

Research output: Contribution to journal › Journal article › Research › peer-review

18 Citations (Scopus)

The novel oxygenated chalcone, 2,4-dimethoxy-4'-butoxychalcone, exhibits potent activity against human malaria parasite Plasmodium falciparum in vitro and rodent parasites Plasmodium berghei and Plasmodium yoelii in vivo

Chen, M., Brøgger Christensen, S., Zhai, L., Rasmussen, M. H., Theander, T. G., Frøkjaer, S., Steffansen, B., Davidsen, J. & Kharazmi, A., 1997, In: Journal of Infectious Diseases. 176, 5, p. 1327-33 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

121 Citations (Scopus)

1996

Drug delivery studies in Caco-2 monolayers. IV. Ethyl glycoside esters as a novel type of absorption enhancers.

Nielsen, H. M., Brøndsted, H., Frøkjær, S. & Hovgaard, L., 1996, In: STP pharma sciences. p. 157-161

Research output: Contribution to journal › Journal article › Research › peer-review

Sven Frøkjær

Research output

Search results