Transport characteristics of L-carnosine and the anticancer derivative 4-toluenesulfonylureido-carnosine in a human epithelial cell line

Carsten Uhd Nielsen; Claudiu T Supuran; Andrea Scozzafava; Sven Frokjaer; Bente Steffansen; Birger Brodin

Transport characteristics of L-carnosine and the anticancer derivative 4-toluenesulfonylureido-carnosine in a human epithelial cell line

Carsten Uhd Nielsen, Claudiu T Supuran, Andrea Scozzafava, Sven Frokjaer, Bente Steffansen, Birger Brodin

31 Citations (Scopus)

Abstract

The aim of the present study was to evaluate whether the transepithelial transport of the anticancer compound 4-toluenesulfonylureido-carnosine (Ts-carnosine) and the dipeptide moiety L-carnosine was due to a hPepT1 carrier-mediated flux.

Original language	English
Journal	Pharmaceutical Research
Volume	19
Issue number	9
Pages (from-to)	1337-44
Number of pages	8
ISSN	0724-8741
Publication status	Published - 2002

Keywords

Antineoplastic Agents
Biological Transport
Caco-2 Cells
Carnosine
Epithelial Cells
Humans
Intestinal Mucosa
Tosyl Compounds

Cite this

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title = "Transport characteristics of L-carnosine and the anticancer derivative 4-toluenesulfonylureido-carnosine in a human epithelial cell line",

abstract = "The aim of the present study was to evaluate whether the transepithelial transport of the anticancer compound 4-toluenesulfonylureido-carnosine (Ts-carnosine) and the dipeptide moiety L-carnosine was due to a hPepT1 carrier-mediated flux.",

keywords = "Antineoplastic Agents, Biological Transport, Caco-2 Cells, Carnosine, Epithelial Cells, Humans, Intestinal Mucosa, Tosyl Compounds",

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T1 - Transport characteristics of L-carnosine and the anticancer derivative 4-toluenesulfonylureido-carnosine in a human epithelial cell line

AU - Nielsen, Carsten Uhd

AU - Supuran, Claudiu T

AU - Scozzafava, Andrea

AU - Frokjaer, Sven

AU - Steffansen, Bente

AU - Brodin, Birger

PY - 2002

Y1 - 2002

N2 - The aim of the present study was to evaluate whether the transepithelial transport of the anticancer compound 4-toluenesulfonylureido-carnosine (Ts-carnosine) and the dipeptide moiety L-carnosine was due to a hPepT1 carrier-mediated flux.

AB - The aim of the present study was to evaluate whether the transepithelial transport of the anticancer compound 4-toluenesulfonylureido-carnosine (Ts-carnosine) and the dipeptide moiety L-carnosine was due to a hPepT1 carrier-mediated flux.

KW - Antineoplastic Agents

KW - Biological Transport

KW - Caco-2 Cells

KW - Carnosine

KW - Epithelial Cells

KW - Humans

KW - Intestinal Mucosa

KW - Tosyl Compounds

M3 - Journal article

C2 - 12403071

SN - 0724-8741

VL - 19

SP - 1337

EP - 1344

JO - Pharmaceutical Research

JF - Pharmaceutical Research

IS - 9

ER -

Transport characteristics of L-carnosine and the anticancer derivative 4-toluenesulfonylureido-carnosine in a human epithelial cell line

Abstract

Keywords

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