Research output per year
Research output per year
Personal profile
Short presentation
The Kornum Lab studies sleep-wake neurophysiology with focus on the hypocretin (hcrt, also called orexin) system. We study how these neurons are affected by the immune system not only in narcolepsy but during sickness in general. We leverage single cell technology, animal disease models and human genetics to explore and discover how hcrt neurons and surrounding cells, networks and pathways are involved in the disease mechanisms of sickness behavior and sleep disorders.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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- 6 Similar Profiles
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Altered surface expression of P2Y11 receptor with narcolepsy-associated mutations
Dommer, M. W., Dreisig, K. & Kornum, B. R., 2019, In: Pharmacological Reports. 71, 5, p. 926-928 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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CD8+ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens
Pedersen, N. W., Holm, A., Kristensen, N. P., Bjerregaard, A.-M., Bentzen, A. K., Marquard, A. M., Tamhane, T., Burgdorf, K. S., Ullum, H., Jennum, P., Knudsen, S., Hadrup, S. R. & Kornum, B. R., 1 Dec 2019, In: Nature Communications. 10, p. 1-12 837.Research output: Contribution to journal › Journal article › Research › peer-review
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CHARACTERIZATION OF REGULATORY NETWORKS BY MULTI-OMICS COMBINING PROTEOMICS WITH BULK AND SINGLE-CELL RNA SEQUENCING IN A DIET-INDUCED AND BIOPSY-CONFIRMED MOUSE MODEL OF NON-ALCOHOLIC STEATOHEPATITIS
AEgidius, H., Veidal, S., Feigh, M., Puglia, M., Hallenborg, P., Vrang, N., Jelsing, J., Kornum, B., Blagoev, B. & Rigbolt, K., 2019, In: Hepatology. 70, Supplement 1, p. 1278A-1279A 2 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment
Bassetti, C. L. A., Adamantidis, A., Burdakov, D., Han, F., Gay, S., Kallweit, U., Khatami, R., Koning, F., Kornum, B. R., Lammers, G. J., Liblau, R. S., Luppi, P. H., Mayer, G., Pollmaecher, T., Sakurai, T., Sallusto, F., Scammell, T. E., Tafti, M. & Dauvilliers, Y., 1 Sept 2019, In: Nature Reviews. Neurology. 15, 9, p. 519-539Research output: Contribution to journal › Review › peer-review
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Sandwich cortial lamination and single-cell analysis decodes the developing spatial processing system
Liu, Y., Bergmann, T. B., Lee, J., Pfisterer, U. G., Handfield, L.-F., Mori, Y., Asenjo Martinez, A., Lisa Vargas, I., Seemann, E. S., Lee, J. T. H., Patikis, N., Peralvo Vidal, J. M., Pihl, M., Kornum, B. R., Thomsen, P. D., Hyttel, P., Witter, M., Khodosevich, K., Gorodkin, J. & Hemberg, M. & 2 others, , 2019. 45 p.Research output: Contribution to conference › Paper › Communication
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DNMT1 regulates expression of MHC class I in post-mitotic neurons
Gustafsson, J. R., Katsioudi, G., Degn, M., Ejlerskov, P., Issazadeh-Navikas, S. & Kornum, B. R., 2018, In: Molecular Brain. 11, 1, p. 1-16 16 p., 36.Research output: Contribution to journal › Journal article › Research › peer-review
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Flow cytometry analysis of T-cell subsets in cerebrospinal fluid of narcolepsy type 1 patients with long-lasting disease
Moresco, M., Lecciso, M., Ocadlikova, D., Filardi, M., Melzi, S., Kornum, B. R., Antelmi, E., Pizza, F., Mignot, E., Curti, A. & Plazzi, G., Apr 2018, In: Sleep Medicine. 44, p. 53-60 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Human P2Y11 expression level affects human P2X7 receptor-mediated cell death
Dreisig, K., Sund, L., Dommer, M. W., Kristensen, N. P., Boddum, K., Viste, R., Fredholm, S., Odum, N., Jäättelä, M., Skov, S. & Kornum, B. R., 2018, In: Frontiers in Immunology. 9, JUN, 12 p., 1159.Research output: Contribution to journal › Journal article › Research › peer-review