Philip Allan Seymour

2019

Mesodermal induction of pancreatic fate commitment

Seymour, P. A. & Serup, P., Aug 2019, In: Seminars in Cell and Developmental Biology. 92, p. 77-88

Research output: Contribution to journal › Review › peer-review

3 Citations (Scopus)

2018

Dll1 and Jag1 are differentially required to specify proximal and distal pancreatic duct compartments.

Seymour, P. A., Collin, C. A., Jorgensen, M. C., Imayoshi, I., Kageyama, R. & Serup, P., 2018, (E-pub ahead of print) In: bioRxiv, Developmental Biology. p. 1-36 36 p.

Research output: Contribution to journal › Journal article › Research

Inhibition of Cdk5 Promotes β-Cell Differentiation From Ductal Progenitors

Liu, K.-C., Leuckx, G., Sakano, D., Seymour, P. A., Mattsson, C. L., Rautio, L., Staels, W., Verdonck, Y., Serup, P., Kume, S., Heimberg, H. & Andersson, O., 1 Jan 2018, In: Diabetes. 67, 1, p. 58-70 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

18 Citations (Scopus)

Mechanosignalling via integrins directs fate decisions of pancreatic progenitors

Mamidi, A., Prawiro, C., Seymour, P. A., de Lichtenberg, K. H., Jackson, A., Serup, P. & Semb, H., 6 Dec 2018, In: Nature. 564, 7734, p. 114-118 5 p.

Research output: Contribution to journal › Letter › peer-review

66 Citations (Scopus)

Notch controls multiple pancreatic cell fate regulators through direct hes1-mediated repression.

de Lichtenberg, K. H., Seymour, P. A., Joergensen, M. C., Kim, Y.-H., Grapin-Botton, A., Magnuson, M. A., Nakic, N., Ferrer, J. & Serup, P., 2018, (E-pub ahead of print) In: bioRxiv, Developmental Biology. p. 1-30 30 p.

Research output: Contribution to journal › Journal article › Research

2016

Research Resource: A Dual Proteomic Approach Identifies Regulated Islet Proteins During β-Cell Mass Expansion In Vivo

Horn, S., Kirkegaard, J. S., Hoelper, S., Seymour, P. A., Rescan, C., Nielsen, J. H., Madsen, O. D., Jensen, J. N., Kruger, M., Gronborg, M. & Ahnfelt-Rønne, J., Jan 2016, In: Molecular endocrinology (Baltimore, Md.). 30, 1, p. 133-143 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

2015

A conserved role for Notch in priming the cellular response to Shh through ciliary localisation of the key Shh transducer, Smoothened

Stasiulewicz, M., Gray, S., Mastromina, I., Silva, J. C., Bjorklund, M., Seymour, P. A., Booth, D., Thompson, C., Green, R., Hall, E. A., Serup, P. & Dale, J. K., 1 Jul 2015, In: Development. 142, p. 2291-2303 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

48 Citations (Scopus)

A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells

Shih, H. P., Seymour, P. A., Patel, N. A., Xie, R., Wang, A., Liu, P. P., Yeo, G. W., Magnuson, M. A. & Sander, M., 13 Oct 2015, In: Cell Reports. 13, 2, p. 326-36 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

39 Citations (Scopus)

Pairing-up SOX to kick-start beta cell genesis

Grapin-Botton, A., Seymour, P. A. & Gradwohl, G., 1 May 2015, In: Diabetologia. 58, 5, p. 859-861 3 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

2014

Sox9: a master regulator of the pancreatic program

Seymour, P. A., 2014, In: The Review of Diabetic Studies. 11, 1, p. 51-83 33 p.

Research output: Contribution to journal › Review › peer-review

44 Citations (Scopus)

2013

Bulking up on beta cells

Seymour, P. A. & Serup, P., 22 Aug 2013, In: Briefings from the New England Journal of Medicine (Spanish Edition). 369, 8, p. 777-9 3 p.

Research output: Contribution to journal › Review › peer-review

8 Citations (Scopus)

2012

A Sox9/Fgf feed-forward loop maintains pancreatic organ identity

Seymour, P. A., Shih, H. P., Patel, N. A., Freude, K. K., Xie, R., Lim, C. J. & Sander, M., 15 Sept 2012, In: Development. 139, 18, p. 3363-72 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

61 Citations (Scopus)

2011

Historical perspective: beginnings of the beta-cell: current perspectives in beta-cell development

Seymour, P. A. & Sander, M., Feb 2011, In: Diabetes. 60, 2, p. 364-76 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

53 Citations (Scopus)

Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas

Kopp, J. L., Dubois, C. L., Schaffer, A. E., Hao, E., Shih, H. P., Seymour, P. A., Ma, J. & Sander, M., 15 Feb 2011, In: Development. 138, 4, p. 653-65 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

311 Citations (Scopus)

Sox9-haploinsufficiency causes glucose intolerance in mice

Dubois, C. L., Shih, H. P., Seymour, P. A., Patel, N. A., Behrmann, J. M., Ngo, V. & Sander, M., 2 Aug 2011, In: P L o S One. 6, 8, p. e23131

Research output: Contribution to journal › Journal article › Research › peer-review

26 Citations (Scopus)

2009

Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function

Wang, S., Jensen, J. N., Seymour, P. A., Hsu, W., Dor, Y., Sander, M., Magnuson, M. A., Serup, P. & Gu, G., 16 Jun 2009, In: PNAS Early Edition. 106, 24, p. 9715-20 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

132 Citations (Scopus)

2008

A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation

Seymour, P. A., Freude, K. K., Dubois, C. L., Shih, H.-P., Patel, N. A. & Sander, M., 1 Nov 2008, In: Advances in Developmental Biology. 323, 1, p. 19-30 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

92 Citations (Scopus)

2007

Immunohistochemical detection of beta-galactosidase or green fluorescent protein on tissue sections

Seymour, P. A. & Sander, M., 2007, In: Methods in Molecular Biology. 411, p. 13-23 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

SOX9 is required for maintenance of the pancreatic progenitor cell pool

Seymour, P. A., Freude, K. K., Tran, M. N., Mayes, E. E., Jensen, J., Kist, R., Scherer, G. & Sander, M., 6 Feb 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 6, p. 1865-70 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

401 Citations (Scopus)

2004

Fission of pancreatic islets during postnatal growth of the mouse

Seymour, P. A., Bennett, W. R. & Slack, J. M. W., Feb 2004, In: Journal of Anatomy. 204, 2, p. 103-16 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

24 Citations (Scopus)

Pancreatic islet progenitor cells in neurogenin 3-yellow fluorescent protein knock-add-on mice

Mellitzer, G., Martín, M., Sidhoum-Jenny, M., Orvain, C., Barths, J., Seymour, P. A., Sander, M. & Gradwohl, G., Nov 2004, In: Molecular Endocrinology. 18, 11, p. 2765-76 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

54 Citations (Scopus)

Philip Allan Seymour

Research output

Search results