Michal Tomasz Marzec

2019

Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 Is Essential for Proinsulin Handling

Ghiasi, S. M., Dahlby, T., Hede Andersen, C., Haataja, L., Petersen, S., Omar-Hmeadi, M., Yang, M., Pihl, C., Bresson, S. E., Khilji, M. S., Klindt, K., Cheta, O., Perone, M. J., Tyrberg, B., Prats, C., Barg, S., Tengholm, A., Arvan, P., Mandrup-Poulsen, T. & Marzec, M. T., 1 Apr 2019, In: Diabetes. 68, 4, p. 747-760 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

MCPIP1 regulates insulin biosynthesis and glucose-stimulated insulin secretion: [Meeting Abstract]

Tyka, K., Brydde, T. H., Wilamowski, M., Jura, J., Marzec, T. & Gurgul-Convey, E., 2019, In: FEBS Open Bio. 9, S1, p. 87-87 P-01-064.

Research output: Contribution to journal › Conference article › Research

2018

Students’ supervision and introduction during the initial period in the research laboratory: does it matter?

Marzec, M. T., 2018, Improving University Science Teaching and Learning: Pedagogical Projects 2018. Department of Science Education, University of Copenhagen, Denmark, p. 107-114 8 p. (Improving University Science Teaching and Learning - Pedagogical Projects, Vol. 12).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

2017

Unexpected profile of sphingolipid contents in blood and bone marrow plasma collected from patients diagnosed with acute myeloid leukemia

WAtek, M., Wollny, T., Pasiarski, M., Gozdz, S., Durnas, B., Wolak, P., Bucki, R., Marzec, M., Chabowska, A. & Zendzian-Piotrowska, M., 8 Dec 2017, In: Lipids in Health and Disease. 16, 1

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

2016

A Human Variant of Glucose-Regulated Protein 94 That Inefficiently Supports IGF Production

Marzec, M., Hawkes, C. P., Eletto, D., Boyle, S., Rosenfeld, R. G., Hwa, V., Wit, J. M., van Duyvenvoorde, H. A., Oostdijk, W., Losekoot, M., Pedersen, O., Yeap, B. B., Flicker, L., Barzilai, N., Atzmon, G., Grimberg, A. & Argon, Y., May 2016, In: Endocrinology. 157, 5, p. 1914-1928 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

Utility of blood procalcitonin concentration in the management of cancer patients with infections

Durnas, B., Watek, M., Wollny, T., Niemirowicz, K., Marzec, M., Bucki, R. & Gozdz, S., 22 Jan 2016, In: OncoTargets and Therapy. 9, p. 469-475

Research output: Contribution to journal › Review › peer-review

17 Citations (Scopus)

2014

Variation in GRP94 Activity Impacts Production of Igfs and Human Growth

Argon, Y., Grimberg, A., Rosenfeld, R. G. & Marzec, M., 2014, In: Endocrine Reviews. 35, 3

Research output: Contribution to journal › Journal article › Research › peer-review

2013

Decreased lactate concentration and glycolytic enzyme expression reflect inhibition of mTOR signal transduction pathway in B-cell lymphoma.

Lee, S.-C., Marzec, M., Liu, X., Wehrli, S., Kantekure, K., Ragunath, P. N., Nelson, D. S., Delikatny, E. J., Glickson, J. D. & Wasik, M. A., Jan 2013, In: NMR in Biomedicine. 26, 1, p. 106-114 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

20 Citations (Scopus)

Malignant transformation of CD4+ T lymphocytes mediated by oncogenic kinase NPM/ALK recapitulates IL-2-induced cell signaling and gene expression reprogramming

Marzec, M., Halasa, K., Liu, X., Wang, H. Y., Cheng, M., Baldwin, D., Tobias, J. W., Schuster, S. J., Andersen, A. W., Zhang, Q., Turner, S. D., Ødum, N. & Wasik, M. A., 15 Dec 2013, In: Journal of immunology (Baltimore, Md. : 1950). 191, 12, p. 6200-7 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

2012

GRP94: An HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum

Marzec, M., Eletto, D. & Argon, Y., Mar 2012, In: B B A - Reviews on Cancer. 1823, 3, p. 774-87 14 p.

Research output: Contribution to journal › Review › peer-review

199 Citations (Scopus)

Prediction and Early Detection of Response by NMR Spectroscopy and Imaging

Lee, S.-C., Arias-Mendoza, F., Poptani, H., Delikatny, E. J., Wasik, M., Marzec, M., Schuster, S. J., Nasta, S. D., Svoboda, J., O'Connor, O. A., Smith, M. R. & Glickson, J. D., Jan 2012, In: PET Clinics. 7, 1, p. 119-26 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

1 Citation (Scopus)

2011

Oncogenic kinase NPM/ALK induces expression of HIF1 alpha mRNA

Marzec, M. T., Liu, X., Wong, W., Yang, Y., Pasha, T., Kantekure, K., Zhang, P., Andersen, A. W., Cheng, M., Ødum, N. & Wasik, M. A., 17 Mar 2011, In: Oncogene. 30, 11, p. 1372-1378 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

23 Citations (Scopus)

Simultaneous inhibition of mTOR-containing complex 1 (mTORC1) and MNK induces apoptosis of cutaneous T-cell lymphoma (CTCL) cells

Marzec, M. T., Liu, X., Wysocka, M., Rook, A. H., Ødum, N. & Wasik, M. A., 16 Sept 2011, In: PLoS ONE. 6, 9, 8 p., e24849.

Research output: Contribution to journal › Journal article › Research › peer-review

47 Citations (Scopus)

57 Downloads (Pure)

2010

Plasma gelsolin modulates cellular response to sphingosine 1-phosphate

Bucki, R., Kulakowska, A., Byfield, F. J., Zendzian-Piotrowska, M., Baranowski, M., Marzec, M., Winer, J. P., Ciccarelli, N. J., Gorski, J., Drozdowski, W., Bittman, R. & Janmey, P. A., Dec 2010, In: American Journal of Physiology: Cell Physiology. 299, 6, p. C1516-23

Research output: Contribution to journal › Journal article › Research › peer-review

43 Citations (Scopus)

2009

Activation of mTORC1 signaling pathway in AIDS-related lymphomas.

El-Salem, M., Raghunath, P. N., Marzec, M., Liu, X., Kasprzycka, M., Robertson, E. & Wasik, M. A., 2009, In: American Journal of Pathology. 175, 2, p. 817-824 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

Anaplastic lymphoma kinase (ALK)-induced malignancies: novel mechanisms of cell transformation and potential therapeutic approaches

Wasik, M. A., Zhang, Q., Marzec, M., Kasprzycka, M., Wang, H. Y. & Liu, X., 2009, In: Seminars in Oncology. 36, 2 Suppl 1, p. S27-35

Research output: Contribution to journal › Journal article › Research › peer-review

31 Citations (Scopus)

2008

Differential effects of interleukin-2 and interleukin-15 versus interleukin-21 on CD4+ cutaneous T-cell lymphoma cells.

Marzec, M., Halasa, K., Kasprzycka, M., Wysocka, M., Liu, X., Tobias, J. W., Baldwin, D., Zhang, Q., Ødum, N. F., Rook, A. H. & Wasik, M. A., 2008, In: Cancer Research. 68, 4, p. 1083-91 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

64 Citations (Scopus)

Expression of FOXP3(+) regulatory T-cell phenotype in neoplastic and reactive cells in early mycosis fungoides

Witkiewicz, A. K., Potoczek, M., Kasprzycka, M., Marzec, M. & Wasik, M., Jan 2008, In: Modern Pathology. 21, p. 103A-103A

Research output: Contribution to journal › Journal article › Research › peer-review

gamma c-signaling cytokines induce a regulatory T cell phenotype in malignant CD4(+) T lymphocytes

Kasprzycka, M., Zhang, Q., Witkiewicz, A., Marzec, M., Potoczek, M., Liu, X., Wang, H. Y., Milone, M., Basu, S., Mauger, J., Choi, J. K., Abrams, J. T., Hou, J. S., Rook, A. H., Vonderheid, E., Woetmann, A., Odum, N. & Wasik, M. A., 15 Aug 2008, In: Journal of Immunology. 181, 4, p. 2506-2512

Research output: Contribution to journal › Journal article › Research › peer-review

IL-2- and IL-15-induced activation of the rapamycin-sensitive mTORC1 pathway in malignant CD4+ T lymphocytes

Marzec, M., Liu, X., Kasprzycka, M., Witkiewicz, A., Raghunath, P. N., El-Salem, M., Robertson, E., Ødum, N. & Wasik, M. A., 2008, In: Blood. 111, 4, p. 2181-9 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

37 Citations (Scopus)

Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)

Marzec, M., Zhang, Q., Goradia, A., Raghunath, P. N., Liu, X., Paessler, M., Wang, H. Y., Wysocka, M., Cheng, M., Ruggeri, B. A. & Wasik, M. A., 30 Dec 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 52, p. 20852-7 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

458 Citations (Scopus)

γc-Signaling Cytokines Induce a Regulatory T Cell Phenotype in Malignant CD4+ T Lymphocytes.

Kasprzycka, M., Zhang, Q., Witkiewicz, A., Marzec, M., Potoczek, M., Liu, X., Wang, H. Y., Milone, M., Basu, S., Mauger, J., Choi, J. K., Abrams, J. T., Hou, J. S., Rook, A. H., Vonderheid, E., Woetmann, A., Odum, N. & Wasik, M. A., 2008, In: Journal of Immunology. 181, 4, p. 2506-2512 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2007

Constitutive activation of mTOR signaling pathway in post-transplant lymphoproliferative disorders.

El-Salem, M., Raghunath, P. N., Marzec, M., Wlodarski, P., Tsai, D., Hsi, E. & Wasik, M. A., 2007, In: Laboratory Investigation. 87, 1, p. 29-39 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

37 Citations (Scopus)

Oncogenic tyrosine kinase NPM/ALK induces activation of the MEK/ERK signaling pathway independently of c-Raf.

Marzec, M., Kasprzycka, M., Liu, X., Raghunath, P. N., Wlodarski, P. & Wasik, M. A., 2007, In: Oncogene. 26, 6, p. 813-821 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

65 Citations (Scopus)

Oncogenic tyrosine kinase NPM/ALK induces activation of the rapamycin-sensitive mTOR signaling pathway.

Marzec, M., Kasprzycka, M., Liu, X., El-Salem, M., Halasa, K., Raghunath, P. N., Bucki, R., Wlodarski, P. & Wasik, M. A., 2007, In: Oncogene. 26, 38, p. 5606-5614 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

77 Citations (Scopus)

PU.1 activates transcription of SHP-1 gene in hematopoietic cells.

Wlodarski, P., Zhang, Q., Liu, X., Kasprzycka, M., Marzec, M. & Wasik, M. A., 2007, In: Journal of Biological Chemistry. 282, 9, p. 6316-6323 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

21 Citations (Scopus)

2006

Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes.

Kasprzycka, M., Majewski, M., Wang, Z.-J., Ptasznik, A., Wysocka, M., Zhang, Q., Marzec, M., Gimotty, P., Crompton, M. R. & Wasik, M. A., 2006, In: American Journal of Pathology. 168, 5, p. 1631-1641 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

31 Citations (Scopus)

Jak3 contributes to the activation of ALK and Stat3 in ALK + anaplastic large cell lymphoma. Response.

Wasik, M. A. & Marzec, M., 2006, In: Laboratory Investigation. 86, 4, p. 420-421 2 p.

Research output: Contribution to journal › Letter

Mantle cell lymphoma cells express predominantly cyclin D1a isoform and are highly sensitive to selective inhibition of CDK4 kinase activity

Marzec, M., Kasprzycka, M., Lai, R., Gladden, A. B., Wlodarski, P., Tomczak, E., Nowell, P., DePrimo, S. E., Sadis, S., Eck, S., Schuster, S. J., Diehl, J. A. & Wasik, M. A., 1 Sept 2006, In: Blood. 108, 5, p. 1744-1750

Research output: Contribution to journal › Journal article › Research › peer-review

116 Citations (Scopus)

Multi-gene epigenetic silencing of tumor suppressor genes in T-cell lymphoma cells; delayed expression of the p16 protein upon reversal of the silencing

Nagasawa, T., Zhang, Q., Raghunath, P. N., Wong, H. Y., El-Salem, M., Szallasi, A., Marzec, M., Gimotty, P., Rook, A. H., Vonderheid, E. C., Odum, N. & Wasik, M. A., 2006, In: Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis. 30, 3, p. 303-12 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

26 Citations (Scopus)

Nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) oncoprotein induces the T regulatory cell phenotype by activating STAT3

Kasprzycka, M., Marzec, M., Liu, X., Zhang, Q. & Wasik, M. A., 27 Jun 2006, In: Proceedings of the National Academy of Sciences of the United States of America. 103, 26, p. 9964-9969

Research output: Contribution to journal › Journal article › Research › peer-review

120 Citations (Scopus)

Peroxisome Proliferator-Activated Receptor γ Promotes Lymphocyte Survival through Its Actions on Cellular Metabolic Activities.

Jo, S.-H., Yang, C., Miao, Q., Marzec, M., Wasik, M. A., Lu, P. & Wang, Y. L., 2006, In: Journal of Immunology. 177, 6, p. 3737-3745 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

31 Citations (Scopus)

2005

Activation of Mammalian Target of Rapamycin in Transformed B Lymphocytes Is Nutrient Dependent but Independent of Akt, Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase, Insulin Growth Factor-I, and Serum.

Wlodarski, P., Kasprzycka, M., Liu, X., Marzec, M., Robertson, E. S., Slupianek, A. & Wasik, M. A., 2005, In: Cancer Research. 65, 17, p. 7800-7808 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

72 Citations (Scopus)

Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3

Marzec, M., Kasprzycka, M., Ptasznik, A., Wlodarski, P., Zhang, Q., Ødum, N. & Wasik, M. A., 2005, In: Laboratory Investigation. 85, 12, p. 1544-54 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

59 Citations (Scopus)

STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes.

Zhang, Q., Wang, H. Y., Marzec, M., Raghunath, P. N., Nagasawa, T. & Wasik, M. A., 2005, In: Proceedings of the National Academy of Sciences of the United States of America. 102, 19, p. 6948-6953 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

193 Citations (Scopus)

Michal Tomasz Marzec

Research output

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