PU.1 activates transcription of SHP-1 gene in hematopoietic cells.

Pawel Wlodarski; Qian Zhang; Xiaobin Liu; Monika Kasprzycka; Michal Marzec; Mariusz A. Wasik

doi:10.1074/jbc.M607526200

PU.1 activates transcription of SHP-1 gene in hematopoietic cells.

Pawel Wlodarski, Qian Zhang, Xiaobin Liu, Monika Kasprzycka, Michal Marzec, Mariusz A. Wasik

21 Citations (Scopus)

Abstract

Protein-tyrosine phosphatase SHP-1 is the key neg. regulator of numerous signaling pathways. SHP-1 is expressed in the hematopietic and epithelial cells as two structurally similar mRNA transcripts controlled by two different promoters designated P2 and P1, resp. Whereas the transcriptional regulation of the SHP-1 gene P1 promoter has been partially elucidated, the structure and functional control of the P2 promoter remain unknown despite the crit. role played by SHP-1 in the normal and malignant lymphoid and other hematopoetic cells. Using luciferase reporter assays with the set of constructs that contained a gradually truncated intron 1 of the SHP-1 gene, we identified the minimal (

Original language	English
Journal	Journal of Biological Chemistry
Volume	282
Issue number	9
Pages (from-to)	6316-6323
Number of pages	8
ISSN	0021-9258
DOIs	https://doi.org/10.1074/jbc.M607526200
Publication status	Published - 2007
Externally published	Yes

Keywords

SHP1 gene transcription activation PU1 hematopoietic cell

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10.1074/jbc.M607526200

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title = "PU.1 activates transcription of SHP-1 gene in hematopoietic cells.",

abstract = "Protein-tyrosine phosphatase SHP-1 is the key neg. regulator of numerous signaling pathways. SHP-1 is expressed in the hematopietic and epithelial cells as two structurally similar mRNA transcripts controlled by two different promoters designated P2 and P1, resp. Whereas the transcriptional regulation of the SHP-1 gene P1 promoter has been partially elucidated, the structure and functional control of the P2 promoter remain unknown despite the crit. role played by SHP-1 in the normal and malignant lymphoid and other hematopoetic cells. Using luciferase reporter assays with the set of constructs that contained a gradually truncated intron 1 of the SHP-1 gene, we identified the minimal (",

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T1 - PU.1 activates transcription of SHP-1 gene in hematopoietic cells.

AU - Wlodarski, Pawel

AU - Zhang, Qian

AU - Liu, Xiaobin

AU - Kasprzycka, Monika

AU - Marzec, Michal

AU - Wasik, Mariusz A.

PY - 2007

Y1 - 2007

N2 - Protein-tyrosine phosphatase SHP-1 is the key neg. regulator of numerous signaling pathways. SHP-1 is expressed in the hematopietic and epithelial cells as two structurally similar mRNA transcripts controlled by two different promoters designated P2 and P1, resp. Whereas the transcriptional regulation of the SHP-1 gene P1 promoter has been partially elucidated, the structure and functional control of the P2 promoter remain unknown despite the crit. role played by SHP-1 in the normal and malignant lymphoid and other hematopoetic cells. Using luciferase reporter assays with the set of constructs that contained a gradually truncated intron 1 of the SHP-1 gene, we identified the minimal (

AB - Protein-tyrosine phosphatase SHP-1 is the key neg. regulator of numerous signaling pathways. SHP-1 is expressed in the hematopietic and epithelial cells as two structurally similar mRNA transcripts controlled by two different promoters designated P2 and P1, resp. Whereas the transcriptional regulation of the SHP-1 gene P1 promoter has been partially elucidated, the structure and functional control of the P2 promoter remain unknown despite the crit. role played by SHP-1 in the normal and malignant lymphoid and other hematopoetic cells. Using luciferase reporter assays with the set of constructs that contained a gradually truncated intron 1 of the SHP-1 gene, we identified the minimal (

KW - SHP1 gene transcription activation PU1 hematopoietic cell

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DO - 10.1074/jbc.M607526200

M3 - Journal article

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EP - 6323

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 9

ER -

PU.1 activates transcription of SHP-1 gene in hematopoietic cells.

Abstract

Keywords

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