Abstract
Protein-tyrosine phosphatase SHP-1 is the key neg. regulator of numerous signaling pathways. SHP-1 is expressed in the hematopietic and epithelial cells as two structurally similar mRNA transcripts controlled by two different promoters designated P2 and P1, resp. Whereas the transcriptional regulation of the SHP-1 gene P1 promoter has been partially elucidated, the structure and functional control of the P2 promoter remain unknown despite the crit. role played by SHP-1 in the normal and malignant lymphoid and other hematopoetic cells. Using luciferase reporter assays with the set of constructs that contained a gradually truncated intron 1 of the SHP-1 gene, we identified the minimal (
| Original language | English |
|---|---|
| Journal | Journal of Biological Chemistry |
| Volume | 282 |
| Issue number | 9 |
| Pages (from-to) | 6316-6323 |
| Number of pages | 8 |
| ISSN | 0021-9258 |
| DOIs | |
| Publication status | Published - 2007 |
| Externally published | Yes |
Keywords
- SHP1 gene transcription activation PU1 hematopoietic cell