Michael Lisby

Kort præsentation

Omdrejningspunktet for min forskning er homolog rekombination (HR) og dens rolle i at opretholde genomets integritet. Vi anvender cellebiologiske og genetiske metoder til at studere HR i gær Saccharomyces cerevisiae og i hvirveldyrcellelinjer herunder humane cellelinjer. Vi er særligt interesseret i regulering af HR gennem post-translationel modifikation af HR-proteiner og kromatinstruktur samt den molekylære arkitektur af HR-komplekser i levende celler. Vi arbejder endvidere for at forstå molekylære mekanismer, der er relevante for cancer, neurologiske lidelser og tidlige aldringssyndromer, og vi benytter genetisk rekombination som et værktøj til at konstruere kombinatoriske genetiske biblioteker til biofarmaceutiske applikationer.

For mere information besøg http://www1.bio.ku.dk/english/research/fg/transkription/

CV

Education

25/10/2000     

Ph.D. degree, Department of Molecular and Structural Biology, Aarhus University, Denmark. Field: Science.

Thesis: The molecular mechanism of type 1B topoisomerases and the catalytic inhibitor camptothecin.

1996-2000     

Graduate studies, Aarhus University, Department of Molecular and Structural Biology, Denmark.

Project: The catalytic mechanism of topoisomerase I and the action of topoisomerase I directed drugs.

1992-1996     

Undergraduate studies at the Department of Molecular and Structural Biology, Aarhus University, Denmark.

Professional / Work Experience

2014- 

Professor in Genome Integrity, Department of Biology, University of Copenhagen

2004-2014     

Associate Professor, Department of Biology, University of Copenhagen, Denmark

2000-2004        

Post doctoral fellow, Department of Genetics and Development, Columbia University, New York, USA

Grants and awards

2009                  

European Research Council, Starting Independent Researcher Grant

Managerial experience

2015-                                                                                                                                                    

Vice-head of Department for research, Department of Biology, University of Copenhagen.

2010-2015                                                                                                                                            

Head of Section. I headed the Section of Functional Genomics at the Department of Biology, University of Copenhagen.