Matthias Manfred Herth

Research output

Research output per year 2005 2019 2020

• 61 Journal article
• 8 Conference abstract for conference
• 8 Conference abstract in journal
• 2 Book chapter
• 3 More
  • 1 Paper
  • 1 Letter
  • 1 Review

Research output per year

Research output per year

Search results

• 2014

  (11)C-labeling and preliminary evaluation of vortioxetine as a PET radioligand

  Andersen, V. L., Hansen, H. D., Herth, M. M., Knudsen, G. M. & Kristensen, J. L., 1 Jun 2014, In: Bioorganic & Medicinal Chemistry Letters. 24, 11, p. 2408-2411 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Vortioxetine 100%
  • Radioligand 59%
  • Brain 15%
  • Amines 11%
  • Major Depressive Disorder 10%
  12 Citations (Scopus)

• Accelerating preclinical PET-screening: reductive amination with [11C]methoxybenzaldehydes

  Herth, M. M., Leth-Petersen, S., Lehel, S., Hansen, M., Gillings, N., Madsen, J. & Kristensen, J. L., 2014, In: R S C Advances. 41, p. 21347-21350 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  9 Citations (Scopus)

• Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT7 receptor

  Lacivita, E., Niso, M., Hansen, H. D., Di Pilato, P., Herth, M. M., Lehel, S., Ettrup, A., Montenegro, L., Perrone, R., Berardi, F., Colabufo, N. A., Leopoldo, M. & Knudsen, G. M., 1 Mar 2014, In: Bioorganic & Medicinal Chemistry. 22, 5, p. 1736-1750 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide 100%
  • Carbon-11 75%
  • serotonin 7 receptor 74%
  • Positron 55%
  • Radioligand 53%
  15 Citations (Scopus)

• Radiosynthesis and in vivo evaluation of novel radioligands for PET imaging of cerebral 5-HT7 receptors

  Hansen, H. D., Herth, M. M., Ettrup, A., Andersen, V. L., Lehel, S., Dyssegaard, A., Kristensen, J. L. & Knudsen, G. M., 1 Apr 2014, In: Journal of Nuclear Medicine. 55, 4, p. 640-646

  Research output: Contribution to journal › Journal article › Research › peer-review

  • 3-(4-(4-(3-methoxyphenyl)piperazine-1-yl)butyl)-1,3-dihydro-2H-indol-2-one 100%
  • Serotonin Receptors 45%
  • SB 269970 27%
  • Serotonin 16%
  • Swine 15%
  22 Citations (Scopus)

• Synthesis, radiolabeling and in vivo evaluation of [C-11](R)-1-[4-[2-(4-methoxyphenyl)phenyl piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor

  Hansen, H. D., Lacivita, E., Di Pilato, P., Herth, M. M., Lehel, S., Ettrup, A., Andersen, V. L., Dyssegaard, A., De Giorgio, P., Perrone, R., Berardi, F., Colabufo, N. A., Niso, M., Knudsen, G. M. & Leopoldo, M., 22 May 2014, In: European Journal of Medicinal Chemistry. 79, p. 152-163 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • serotonin 7 receptor 100%
  • Radioligand 71%
  • SB 269970 28%
  • Swine 25%
  • Carbon-11 25%
  16 Citations (Scopus)
• 2013

  Comparison of the 5-HT2A PET tracers, [F-18]MH.MZ and [F-18]altanserin

  Hansen, H., Herth, M. M., Ettrup, A., Dyssegaard, A. & Knudsen, K. B. M., May 2013, p. S338-S338.

  Research output: Contribution to conference › Conference abstract for conference › Research

• Development of a 11C-labeled tetrazine for rapid tetrazine–trans-cyclooctene ligation

  Herth, M. M., Andersen, V. L., Lehel, S., Madsen, J., Knudsen, G. M. & Kristensen, J. L., 9 Apr 2013, In: Chemical Communications. 49, p. 3805-3807 3 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  49 Citations (Scopus)

• Development of C-11-labeled oxindole derivatives for in vivo PET imaging of the 5-HT7 receptor

  Herth, M. M., Hansen, H., Andersen, V. L., Volk, B., Ettrup, A., Antoni, F., Lehel, S., Dyssegaard, A., Kristensen, J. L. & Knudsen, G. M., May 2013, p. S82-S82.

  Research output: Contribution to conference › Conference abstract for conference › Research

• Direct comparison of [18F]MH.MZ and [18F]altanserin for 5-HT2A receptor imaging with PET

  Hansen, H. D., Ettrup, A., Herth, M. M., Dyssegaard, A., Ratner, C., Gillings, N. & Knudsen, G. M., Jun 2013, In: Synapse. 67, 6, p. 328-337 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • altanserin 100%
  • Receptor, Serotonin, 5-HT2A 69%
  • Positron-Emission Tomography 49%
  • volinanserin 45%
  • Swine 26%
  14 Citations (Scopus)

• Palladium-mediated conversion of para-aminoarylboronic esters into para-aminoaryl- 11C-methanes

  Andersen, V. L., Herth, M. M., Lehel, S., Knudsen, G. M. & Kristensen, J. L., 16 Jan 2013, In: Tetrahedron Letters. 54, 3, p. 213-216 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Palladium 100%
  • Methane 90%
  • Amines 69%
  • Esters 66%
  • Ester 39%
  9 Citations (Scopus)

• Synthesis and evaluation of [C-11]CIMBI-712 and [C-11]CIMBI-772

  Andersen, V. L., Herth, M. M., Hansen, H. D., Kristensen, J. L. & Knudsen, K. B. M., May 2013, p. S101-S101.

  Research output: Contribution to conference › Conference abstract for conference › Research
• 2012

  Development of an F-18-labelled 5-HT2A receptor agonist PET radioligand

  Ettrup, A., Hansen, M., Gillings, N., Dyssegaard, A., Lehel, S., Hansen, H. D., Herth, M. M., Madsen, J., Kristensen, J. & Knudsen, G. M., Aug 2012, In: Journal of Cerebral Blood Flow and Metabolism. 32, p. S109-S109

  Research output: Contribution to journal › Journal article › Research › peer-review

• Direct radiofluorination of [18F]MH.MZ for 5-HT2A receptor molecular imaging with PET

  Herth, M. M., Kramer, V., Gillings, N., Roesch, F. & Knudsen, G. M., Jul 2012, In: Journal of Labelled Compounds and Radiopharmaceuticals. 55, 9, p. 354-358

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Altanserin 100%
  • volinanserin 82%
  • Receptor, Serotonin, 5-HT2A 63%
  • Molecular Imaging 57%
  • Positron 56%
  5 Citations (Scopus)

• In vivo PET imaging of cerebral 5-HT7 receptors with novel radioligands

  Hansen, H. D., Herth, M. M., Ettrup, A., Szabolcs, L., Dyssegaard, A., Kristensen, J. & Knudsen, G. M., Aug 2012, In: Journal of Cerebral Blood Flow and Metabolism. 32, p. S126-S127

  Research output: Contribution to journal › Journal article › Research › peer-review

• Synthesis and evaluation of [11C]Cimbi-806 as a potential PET ligand for 5-HT₇ receptor imaging

  Herth, M. M., Hansen, H. D., Ettrup, A. J., Dyssegaard, A., Lehel, S., Kristensen, J. L. & Knudsen, G. M., 15 Jul 2012, In: Bioorganic and Medicinal Chemistry. 20, 14, p. 4574-4581 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • serotonin 7 receptor 100%
  • Positron 74%
  • Positron-Emission Tomography 59%
  • Radioligand 47%
  • Ligands 45%
  16 Citations (Scopus)

• Synthesis and In Vitro Evaluation of Oxindole Derivatives as Potential Radioligands for 5-HT7 Receptor Imaging with PET

  Herth, M. M., Volk, B., Pallagi, K., Koefoed Bech, L., A. Antoni, F., Knudsen, G. M. & Kristensen, J. L., 19 Dec 2012, In: ACS Chemical Neuroscience. 3, 12, p. 1002-1007

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Oxindoles 100%
  • serotonin 7 receptor 88%
  • Positron 66%
  • Radioligand 63%
  • Positron-Emission Tomography 53%
  20 Citations (Scopus)

• Three weeks of daily exposure to bright light does not alter striatal serotonin transporter binding in healthy Scandinavians

  Mc Mahon, B., Andersen, A. S., Feng, L., Madsen, M. K., Lehel, S., Herth, M. M., Iversen, P., Hasholt, L. & Knudsen, G. M., Aug 2012, In: Journal of Cerebral Blood Flow and Metabolism. 32, p. S79-S80

  Research output: Contribution to journal › Journal article › Research › peer-review
• 2011

  Development of New PET Radiotracers for In Vivo 5-HT7 Brain Imaging

  Herth, M. M., Hansen, H., Lehel, S., Ettrup, A., Paine, J., Madsen, J., Gillings, N., Kristensen, J. & Knudsen, G., 2011, In: Journal of Labelled Compounds and Radiopharmaceuticals. 54, p. S277-S277

  Research output: Contribution to journal › Journal article › Research › peer-review

• P-Glycoprotein Influence on the Brain Uptake of a 5-HT2A Ligand: [F-18]MH.MZ

  Schmitt, U., Leed, D. E., Herth, M. M., Piel, M., Buchholz, H-G., Roesch, F., Hiemke, C., Lueddens, H. & Debus, F., Feb 2011, In: Neuropsychobiology. 63, 3, p. 183-190

  Research output: Contribution to journal › Journal article › Research › peer-review

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 100%
  • Ligands 64%
  • Receptor, Serotonin, 5-HT2A 51%
  • Brain 44%
  • Knockout Mice 35%
  4 Citations (Scopus)

• Radiosynthesis and in vivo evaluation of a series of substituted ¹¹C-phenethylamines as 5-HT_2A agonist PET tracers

  Ettrup, A., Hansen, M., Santini, M. A., Paine, J. S., Gillings, N., Palner, M., Lehel, S., Herth, M. M., Madsen, J., Kristensen, J. L., Begtrup, M. & Knudsen, G. M., 1 Apr 2011, In: European Journal of Nuclear Medicine and Molecular Imaging. 38, 4, p. 681-693

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Phenethylamines 100%
  • Serotonin 5-HT2 Receptor Agonists 95%
  • Receptor, Serotonin, 5-HT2A 85%
  • Positron-Emission Tomography 60%
  • Cimbi-36 52%
  92 Citations (Scopus)
• 2010

  18F-labeling and evaluation of novel MDL 100907 derivatives as potential 5-HT2A antagonists for molecular imaging

  Debus, F., Herth, M. M., Piel, M., Buchholz, H-G., Bausbacher, N., Kramer, V., Lüddens, H. & Rösch, F., May 2010, In: Nuclear Medicine and Biology. 37, 4, p. 487-95 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • volinanserin 100%
  • Serotonin 5-HT2 Receptor Antagonists 80%
  • Receptor, Serotonin, 5-HT2A 77%
  • Molecular Imaging 69%
  • Autoradiography 61%
  19 Citations (Scopus)

• 72/74As-labeling of HPMA based polymers for long-term in vivo PET imaging

  Herth, M. M., Barz, M., Jahn, M., Zentel, R. & Rösch, F., 15 Sept 2010, In: Bioorganic & Medicinal Chemistry Letters. 20, 18, p. 5454-8 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Duxon 100%
  • Positron 60%
  • Positron-Emission Tomography 48%
  • Polymers 46%
  • Radio 26%
  37 Citations (Scopus)

• Novel, Versatile Three-Step Synthesis of 1,2,3,4,10,10a-Hexahydropyrazino[1,2-a]indoles by Intramolecular Carbene-Mediated C-H Insertion

  Krogsgaard-Larsen, N., Begtrup, M., Herth, M. M. & Kehler, J., Dec 2010, In: Synthesis. 24, p. 4287-4299

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Azepane 100%
  • Scaffolds 69%
  • Morpholine 66%
  • Pyrrolidine 63%
  • Piperazine 62%
  16 Citations (Scopus)

• Structural combination of established 5-HT(2A) receptor ligands: new aspects of the binding mode

  Kramer, V., Herth, M. M., Santini, M. A., Palner, M., Knudsen, G. M. & Rösch, F., 1 Oct 2010, In: Chemical Biology & Drug Design (Online). 76, 4, p. 361-6 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Altanserin 100%
  • SR 46349B 97%
  • altanserin 91%
  • volinanserin 82%
  • piperidine 69%
  5 Citations (Scopus)
• 2009

  Preliminary in vivo and ex vivo evaluation of the 5-HT2A imaging probe [F-18]MH.MZ

  Herth, M. M., Piel, M., Debus, F., Schmitt, U., Lueddens, H. & Roesch, F., May 2009, In: Nuclear Medicine and Biology. 36, 4, p. 447-454

  Research output: Contribution to journal › Journal article › Research › peer-review

  21 Citations (Scopus)

• Radioactive labeling of defined HPMA-based polymeric structures using [18F]FETos for in vivo imaging by positron emission tomography

  Herth, M. M., Barz, M., Moderegger, D., Allmeroth, M., Jahn, M., Thews, O., Zentel, R. & Rösch, F., 13 Jul 2009, In: Biomacromolecules. 10, 7, p. 1697-703 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Positron emission tomography 100%
  • Tyramine 93%
  • Positron 84%
  • Labeling 70%
  • Block Copolymer 58%
  81 Citations (Scopus)

• Synthesis, radiofluorination and first evaluation of (+/-)-[F-18]MDL 100907 as serotonin 5-HT2A receptor antagonist for PET

  Muehlhausen, U., Ermert, J., Herth, M. M. & Coenen, H. H., 2009, In: Journal of Labelled Compounds and Radiopharmaceuticals. 52, 1-2, p. 6-12

  Research output: Contribution to journal › Journal article › Research › peer-review

  18 Citations (Scopus)

• Synthesis and in vitro affinities of various MDL 100907 derivatives as potential F-18-radioligands for 5-HT2A receptor imaging with PET

  Herth, M. M., Kramer, V., Piel, M., Palner, M., Riss, P. J., Knudsen, G. M. & Roesch, F., 15 Apr 2009, In: Bioorganic & Medicinal Chemistry. 17, 8, p. 2989-3002

  Research output: Contribution to journal › Journal article › Research › peer-review

  33 Citations (Scopus)

• Synthesis of novel WAY 100635 derivatives containing a norbornene group and radiofluorination of [F-18]AH1.MZ as a serotonin 5-HT1A receptor antagonist for molecular imaging

  Herth, M. M., Kramer, V. & Roesch, F., 15 May 2009, In: Journal of Labelled Compounds and Radiopharmaceuticals. 52, 5-6, p. 201-207

  Research output: Contribution to journal › Journal article › Research › peer-review

  6 Citations (Scopus)
• 2008

  Total synthesis and evaluation of [18F]MHMZ

  Herth, M. M., Debus, F., Piel, M., Palner, M., Knudsen, G. M., Lüddens, H. & Rösch, F., 2008, In: Bioorganic & Medicinal Chemistry Letters. 18, 4, p. 1515-1519 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • MDL 105725 100%
  • Receptor, Serotonin, 5-HT2A 52%
  • Radiochemical Yield 48%
  • Total Synthesis 34%
  • Injections 23%
  22 Citations (Scopus)
• 2007

  11C-imaging: methyl jasmonate moves in both phloem and xylem, promotes transport of jasmonate, and of photoassimilate even after proton transport is decoupled

  Thorpe, M. R., Ferrieri, A. P., Herth, M. M. & Ferrieri, R. A., Jul 2007, In: Planta. 226, 2, p. 541-51 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • methyl jasmonate 100%
  • jasmonic acid 99%
  • Phloem 98%
  • Xylem 95%
  • Jasmonates 93%
  136 Citations (Scopus)
• 2005

  Synthesis of the phytohormone [11C]methyl jasmonate via methylation on a C18 Sep Pak™ cartridge

  Herth, M. M., Thorpe, M. R. & Ferrieri, R. A., 1 Apr 2005, In: Journal of Labelled Compounds and Radiopharmaceuticals. 48, 5, p. 379-386 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • methyl jasmonate 100%
  • jasmonic acid 99%
  • octadecyl silane-bonded silica 98%
  • methyl iodide 95%
  • Jasmonates 93%
  7 Citations (Scopus)