72/74As-labeling of HPMA based polymers for long-term in vivo PET imaging

TY - JOUR

T1 - 72/74As-labeling of HPMA based polymers for long-term in vivo PET imaging

AU - Herth, Matthias M

AU - Barz, Matthias

AU - Jahn, Markus

AU - Zentel, Rudolf

AU - Rösch, Frank

N1 - Copyright (c) 2010 Elsevier Ltd. All rights reserved.

PY - 2010/9/15

Y1 - 2010/9/15

N2 - In the context of molecular imaging, various polymers based on the clinically approved N-(2-hydroxypropyl)-methacrylamide (HPMA) have been radio-labeled using longer-living positron emitters 72As t1/2=26 h or 74As t1/2=17.8 d. This approach may lead to non-invasive determination of the long-term in vivo fate of polymers by PET (positron emission tomography). Presumably, the radio label itself will not strongly influence the polymer structure due to the fact that the used nuclide binds to already existing thiol moieties within the polymer structure. Thus, the use of additional charges or bulky groups can be avoided.

AB - In the context of molecular imaging, various polymers based on the clinically approved N-(2-hydroxypropyl)-methacrylamide (HPMA) have been radio-labeled using longer-living positron emitters 72As t1/2=26 h or 74As t1/2=17.8 d. This approach may lead to non-invasive determination of the long-term in vivo fate of polymers by PET (positron emission tomography). Presumably, the radio label itself will not strongly influence the polymer structure due to the fact that the used nuclide binds to already existing thiol moieties within the polymer structure. Thus, the use of additional charges or bulky groups can be avoided.

KW - Acrylamides

KW - Arsenic

KW - Positron-Emission Tomography

KW - Radioisotopes

KW - Time Factors

U2 - 10.1016/j.bmcl.2010.07.092

DO - 10.1016/j.bmcl.2010.07.092

M3 - Journal article

C2 - 20709549

SN - 0960-894X

VL - 20

SP - 5454

EP - 5458

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

IS - 18

ER -