Synthesis, radiolabeling and in vivo evaluation of [C-11](R)-1-[4-[2-(4-methoxyphenyl)phenyl piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor

Hanne D. Hansen; Enza Lacivita; Pantaleo Di Pilato; Matthias Manfred Herth; Szabolcs Lehel; Anders Ettrup; Valdemar L. Andersen; Agnete Dyssegaard; Paola De Giorgio; Roberto Perrone; Francesco Berardi; Nicola Antonio Colabufo; Mauro Niso; Gitte M. Knudsen; Marcello Leopoldo

doi:10.1016/j.ejmech.2014.03.066

Synthesis, radiolabeling and in vivo evaluation of [C-11](R)-1-[4-[2-(4-methoxyphenyl)phenyl piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor

Hanne D. Hansen, Enza Lacivita, Pantaleo Di Pilato, Matthias Manfred Herth, Szabolcs Lehel, Anders Ettrup, Valdemar L. Andersen, Agnete Dyssegaard, Paola De Giorgio, Roberto Perrone, Francesco Berardi, Nicola Antonio Colabufo, Mauro Niso, Gitte M. Knudsen, Marcello Leopoldo

16 Citations (Scopus)

Original language	English
Journal	European Journal of Medicinal Chemistry
Volume	79
Pages (from-to)	152-163
Number of pages	12
ISSN	0223-5234
DOIs	https://doi.org/10.1016/j.ejmech.2014.03.066
Publication status	Published - 22 May 2014

Keywords

5-HT7 receptor
PET
Radioligand
Arylpiperazine
SB-269970

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Hansen, H. D., Lacivita, E., Di Pilato, P., Herth, M. M., Lehel, S., Ettrup, A., Andersen, V. L., Dyssegaard, A., De Giorgio, P., Perrone, R., Berardi, F., Colabufo, N. A., Niso, M., Knudsen, G. M., & Leopoldo, M. (2014). Synthesis, radiolabeling and in vivo evaluation of [C-11](R)-1-[4-[2-(4-methoxyphenyl)phenyl piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor. European Journal of Medicinal Chemistry, 79, 152-163. https://doi.org/10.1016/j.ejmech.2014.03.066

Synthesis, radiolabeling and in vivo evaluation of [C-11](R)-1-[4-[2-(4-methoxyphenyl)phenyl piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor. / Hansen, Hanne D.; Lacivita, Enza; Di Pilato, Pantaleo et al.

In: European Journal of Medicinal Chemistry, Vol. 79, 22.05.2014, p. 152-163.

Research output: Contribution to journal › Journal article › Research › peer-review

Hansen, HD, Lacivita, E, Di Pilato, P, Herth, MM, Lehel, S, Ettrup, A, Andersen, VL, Dyssegaard, A, De Giorgio, P, Perrone, R, Berardi, F, Colabufo, NA, Niso, M, Knudsen, GM & Leopoldo, M 2014, 'Synthesis, radiolabeling and in vivo evaluation of [C-11](R)-1-[4-[2-(4-methoxyphenyl)phenyl piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor', European Journal of Medicinal Chemistry, vol. 79, pp. 152-163. https://doi.org/10.1016/j.ejmech.2014.03.066

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title = "Synthesis, radiolabeling and in vivo evaluation of [C-11](R)-1-[4-[2-(4-methoxyphenyl)phenyl piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor",

keywords = "5-HT7 receptor, PET, Radioligand, Arylpiperazine, SB-269970",

author = "Hansen, {Hanne D.} and Enza Lacivita and {Di Pilato}, Pantaleo and Herth, {Matthias Manfred} and Szabolcs Lehel and Anders Ettrup and Andersen, {Valdemar L.} and Agnete Dyssegaard and {De Giorgio}, Paola and Roberto Perrone and Francesco Berardi and Colabufo, {Nicola Antonio} and Mauro Niso and Knudsen, {Gitte M.} and Marcello Leopoldo",

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AU - Hansen, Hanne D.

AU - Lacivita, Enza

AU - Di Pilato, Pantaleo

AU - Herth, Matthias Manfred

AU - Lehel, Szabolcs

AU - Ettrup, Anders

AU - Andersen, Valdemar L.

AU - Dyssegaard, Agnete

AU - De Giorgio, Paola

AU - Perrone, Roberto

AU - Berardi, Francesco

AU - Colabufo, Nicola Antonio

AU - Niso, Mauro

AU - Knudsen, Gitte M.

AU - Leopoldo, Marcello

PY - 2014/5/22

Y1 - 2014/5/22

KW - 5-HT7 receptor

KW - PET

KW - Radioligand

KW - Arylpiperazine

KW - SB-269970

U2 - 10.1016/j.ejmech.2014.03.066

DO - 10.1016/j.ejmech.2014.03.066

M3 - Journal article

C2 - 24732791

SN - 0223-5234

VL - 79

SP - 152

EP - 163

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

ER -

Synthesis, radiolabeling and in vivo evaluation of [C-11](R)-1-[4-[2-(4-methoxyphenyl)phenyl piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor

Keywords

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