Johan Peter Bøtker

2020

Expedited investigation of powder caking aided by rapid 3D prototyping of testing devices

Hirschberg, C., Boetker, J., Risbo, J., Sun, C. C. & Rantanen, J., Jan 2020, In: Journal of Pharmaceutical Sciences. 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2019

Cryptopharmaceuticals: increasing the safety of medication by a blockchain of pharmaceutical products

Nørfeldt, L., Bøtker, J., Edinger, M., Genina, N. & Rantanen, J., Sept 2019, In: Journal of Pharmaceutical Sciences.

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

Improving Powder Characteristics by Surface Modification Using Atomic Layer Deposition

Hirschberg, C., Jensen, N. S., Boetker, J., Madsen, A. Ø., Kääriäinen, T. O., Kääriäinen, M.-L., Hoppu, P., George, S. M., Murtomaa, M., Sun, C. C., Risbo, J. & Rantanen, J., 15 Nov 2019, In: Organic Process Research & Development. 23, 11, p. 2362-2368

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

Microfluidics-based self-assembly of peptide-loaded microgels: Effect of three dimensional (3D) printed micromixer design

Borro, B. C., Bohr, A., Bucciarelli, S., Boetker, J. P., Foged, C., Rantanen, J. & Malmsten, M., 7 Mar 2019, In: Journal of Colloid and Interface Science. 538, p. 559-568 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

Roadmap to 3D printed oral pharmaceutical dosage forms: Feedstock filament properties and characterization for fused deposition modeling

Aho, J., Bøtker, J. P., Genina, N., Edinger, M., Arnfast, L. & Rantanen, J., Jan 2019, In: Journal of Pharmaceutical Sciences. 108, 1, p. 26–35

Research output: Contribution to journal › Journal article › Research › peer-review

50 Citations (Scopus)

The Use of 3D Printed Molds to Cast Tablets with a Designed Disintegration Profile

Ajmal, A., Meskarzadeh, A., Genina, N., Hirschberg, C., Boetker, J. P. & Rantanen, J., 1 Apr 2019, In: AAPS PharmSciTech. 20, 3, 10 p., 127.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

Unidirectional drug release from 3D printed mucoadhesive buccal films using FDM technology: In vitro and ex vivo evaluation

Eleftheriadis, G. K., Ritzoulis, C., Bouropoulos, N., Tzetzis, D., Andreadis, D. A., Boetker, J., Rantanen, J. & Fatouros, D. G., Nov 2019, In: European Journal of Pharmaceutics and Biopharmaceutics. 144, p. 180-192 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

30 Citations (Scopus)

2018

Additive manufacturing of prototype elements with process interfaces for continuously operating manufacturing lines: Formulation strategies and manufacturing technologies to enhance non-invasive drug delivery

Hirschberg, C., Schmidt Larsen, M., Bøtker, J. P. & Rantanen, J., 2018, In: Asian Journal of Pharmaceutical Sciences. 13, 6, p. 575-583 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

28 Downloads (Pure)

Characterisation of pore structures of pharmaceutical tablets: A review

Markl, D., Strobel, A., Schlossnikl, R., Bøtker, J., Bawuah, P., Ridgway, C., Rantanen, J., Rades, T., Gane, P., Peiponen, K.-E. & Zeitler, J. A., 1 Mar 2018, In: International Journal of Pharmaceutics. 538, 1, p. 188-214 27 p.

Research output: Contribution to journal › Journal article › Research › peer-review

44 Citations (Scopus)

Transforming nanomedicine manufacturing toward Quality by Design and microfluidics

Colombo, S., Beck-Broichsitter, M., Bøtker, J. P., Malmsten, M., Rantanen, J. & Bohr, A., 15 Mar 2018, In: Advanced Drug Delivery Reviews. 128, p. 115-131

Research output: Contribution to journal › Journal article › Research › peer-review

30 Citations (Scopus)

Using 3D Printing for Rapid Prototyping of Characterization Tools for Investigating Powder Blend Behavior

Hirschberg, C., Boetker, J. P., Rantanen, J. & Pein-Hackelbusch, M., 1 Feb 2018, In: AAPS PharmSciTech. 19, 2, p. 941–950

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

2017

Analysis of 3D Prints by X-ray Computed Microtomography and Terahertz Pulsed Imaging

Markl, D., Zeitler, J. A., Rasch, C., Michaelsen, M. H., Müllertz, A., Rantanen, J., Rades, T. & Bøtker, J., 1 May 2017, In: Pharmaceutical Research. 34, 5, p. 1037–1052 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

43 Citations (Scopus)

351 Downloads (Pure)

Anti-tuberculosis drug combination for controlled oral delivery using 3D printed compartmental dosage forms: From drug product design to in vivo testing

Genina, N., Boetker, J. P., Colombo, S., Harmankaya, N., Rantanen, J. & Bohr, A., 28 Dec 2017, In: Journal of Controlled Release. 268, p. 40-48

Research output: Contribution to journal › Journal article › Research › peer-review

95 Citations (Scopus)

Dehydration of Nitrofurantoin Monohydrate during Melt Extrusion

Raijada, D., Arnfast, L., Bond, A. D., Aho, J., Bøtker, J., Sandler, N. & Rantanen, J., 5 Jul 2017, In: Crystal Growth & Design. 17, 7, p. 3707-3715 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

High-Throughput Fabrication of Nanocomplexes Using 3D-Printed Micromixers

Bohr, A., Boetker, J., Wang, Y., Jensen, H., Rantanen, J. & Beck-Broichsitter, M., 1 Mar 2017, In: Journal of Pharmaceutical Sciences. 106, 3, p. 835-842 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Inhalable siRNA-loaded nano-embedded microparticles engineered using microfluidics and spray drying

Agnoletti, M., Bohr, A., Thanki, K., Wan, F., Zeng, X., Bøtker, J. P., Yang, M. & Foged, C., Nov 2017, In: European Journal of Pharmaceutics and Biopharmaceutics. 120, p. 9-21

Research output: Contribution to journal › Journal article › Research › peer-review

20 Citations (Scopus)

The effect of HPMC and MC as pore formers on the rheology of the implant microenvironment and the drug release in vitro

Aho, J., Halme, A., Boetker, J., Water, J. J., Bohr, A., Sandler, N., Rantanen, J. & Baldursdottir, S., 1 Dec 2017, In: Carbohydrate Polymers. 177, p. 433-442 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

Toward quality assessment of 3D printed oral dosage forms

Markl, D., Zeitler, A., Rades, T., Rantanen, J. & Bøtker, J., 15 Dec 2017, In: Journal of 3D Printing in Medicine. 2, 1, p. 27-33 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2016

Anhydrate to hydrate solid-state transformations of carbamazepine and nitrofurantoin in biorelevant media studied in situ using time-resolved synchrotron X-ray diffraction

Bøtker, J. P., Rantanen, J., Arnfast, L., Doreth, M., Raijada, D. K., Löbmann, K., Madsen, C. M., Khan, J., Rades, T., Müllertz, A., Hawley, A., Thomas, D. & Boyd, B. J., 1 Mar 2016, In: European Journal of Pharmaceutics and Biopharmaceutics. 100, p. 119-127 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

In silico product design of pharmaceuticals

Boetker, J., Raijada, D., Aho, J., Khorasani, M., Søgaard, S. V., Arnfast, L., Bohr, A., Edinger, M., Water, J. & Rantanen, J., 1 Aug 2016, In: Asian Journal of Pharmaceutical Sciences. 11, 4, p. 492–499 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

113 Downloads (Pure)

Modifying release characteristics from 3D printed drug-eluting products

Boetker, J., Water, J., Aho, J., Arnfast, L., Bohr, A. & Rantanen, J., 30 Jul 2016, In: European Journal of Pharmaceutical Sciences. 90, p. 47-52 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

68 Citations (Scopus)

Near-infrared chemical imaging (NIR-CI) of 3D printed pharmaceuticals

Khorasani, M., Edinger, M., Raijada, D. K., Bøtker, J., Aho, J. & Rantanen, J., 30 Dec 2016, In: International Journal of Pharmaceutics. 515, 1–2, p. 324-330 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

Oscillatory Shear Rheology in Examining the Drug-Polymer Interactions Relevant in Hot Melt Extrusion

Aho, J., Edinger, M., Botker, J., Baldursdottir, S. & Rantanen, J., Jan 2016, In: Journal of Pharmaceutical Sciences. 105, 1, p. 160-7 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

24 Citations (Scopus)

Physical Stability of Freeze-Dried Isomalt Diastereomer Mixtures

Koskinen, A.-K., Fraser-Miller, S. J., Bøtker, J. P., Heljo, V. P., Barnsley, J. E., Gordon, K. C., Strachan, C. J. & Juppo, A. M., 1 Jul 2016, In: Pharmaceutical Research. 33, 7, p. 1752–1768 17 p.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

2015

Rheology as a tool for evaluation of melt processability of innovative dosage forms

Aho, J. M., Boetker, J. P., Baldursdottir, S. & Rantanen, J., 30 Oct 2015, In: International Journal of Pharmaceutics. 494, 2, p. 623–642 20 p.

Research output: Contribution to journal › Journal article › Research › peer-review

92 Citations (Scopus)

Three-Dimensional Printing of Drug-Eluting Implants: Preparation of an Antimicrobial Polylactide Feedstock Material

Water, J. J., Bohr, A., Bøtker, J. P., Aho, J., Sandler, N., Nielsen, H. M. & Rantanen, J., Mar 2015, In: Journal of Pharmaceutical Sciences. p. 1099–1107 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

85 Citations (Scopus)

2014

Application of spray-drying and electrospraying/electospinning for poorly water-soluble drugs: a particle engineering approach

Bohr, A., Boetker, J. P., Rades, T., Rantanen, J. & Yang, M., 2014, In: Current Pharmaceutical Design. 20, 3, p. 325-48 24 p.

Research output: Contribution to journal › Journal article › Research › peer-review

36 Citations (Scopus)

Simultaneous UV Imaging and Raman Spectroscopy for the Measurement of Solvent-Mediated Phase Transformations During Dissolution Testing

Ostergaard, J., Wu, J., Naelapää, K., Boetker, J. P., Jensen, H. & Rantanen, J., Apr 2014, In: Journal of Pharmaceutical Sciences. 103, 4, p. 1149-56 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

35 Citations (Scopus)

Solubility of small-molecule drugs into polymer excipients in hot melt extruded dosage forms

Aho, J. M., Bøtker, J. P., Baldursdottir, S. G. & Rantanen, J., 2014, In: Annual transactions of the Nordic Rheology Society. 22, p. 55-59

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

2013

A new approach to dissolution testing by UV imaging and finite element simulations

Bøtker, J. P., Rantanen, J., Rades, T., Müllertz, A., Ostergaard, J. & Jensen, H., May 2013, In: Pharmaceutical Research. 30, 5, p. 1328-1337

Research output: Contribution to journal › Journal article › Research › peer-review

30 Citations (Scopus)

Application of spray-drying and electrospraying/electospinning for poorly water-soluble drugs: a particle engineering approach

Bohr, A. J., Bøtker, J. P., Rades, T., Rantanen, J. & Yang, M., 2013, In: Current Pharmaceutical Design. 20, 3, p. 325-348

Research output: Contribution to journal › Journal article › Research › peer-review

Detecting phase separation of freeze-dried binary amorphous systems using pair-wise distribution function and multivariate data analysis

Chieng, N., Trnka, H., Boetker, J., Pikal, M., Rantanen, J. & Grohganz, H., 18 Jul 2013, In: International Journal of Pharmaceutics. 454, 1, p. 167-173 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

Indomethacin: New polymorphs of an old drug

Surwase, S. A., Bøtker, J. P., Saville, D., Boyd, B. J., Gordon, K. C., Peltonen, L. & Strachan, C. J., 2 Dec 2013, In: Molecular Pharmaceutics. 10, 12, p. 4472-4480

Research output: Contribution to journal › Journal article › Research › peer-review

80 Citations (Scopus)

Real-time in vitro dissolution of 5-aminosalicylic acid from single ethyl cellulose coated extrudates studied by UV imaging

Gaunø, M. H., Vilhelmsen, T., Larsen, C. C., Bøtker, J. P., Wittendorff, J., Rantanen, J. & Ostergaard, J., Sept 2013, In: Journal of Pharmaceutical and Biomedical Analysis. 83, p. 49-56 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

2012

Atomic pairwise distribution function analysis of the amorphous phase prepared by different manufacturing routes

Boetker, J. P., Koradia, V., Rades, T., Rantanen, J. & Savolainen, M., Mar 2012, In: Pharmaceutics. 4, 1, p. 93-103 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

Polymorphic form of piroxicam influences the performance of armorphous material prepared by ball-milling

Naelapaa, K., Bøtker, J. P., Veski, P., Rantanen, J., Rades, T. & Kogermann, K., 15 Jun 2012, In: International Journal of Pharmaceutics. 429, 1-2, p. 69-77

Research output: Contribution to journal › Journal article › Research › peer-review

20 Citations (Scopus)

Structural elucidationof rapid solution-mediatedPhase transitions in pharmaceutical solids using in situ synchrotron SAXS/WAXS

Bøtker, J. P., Rades, T., Rantanen, J., Hawley, A. & Boyd, B. J., 4 Sept 2012, In: Molecular Pharmaceutics. 9, 9, p. 2787-2791

Research output: Contribution to journal › Journal article › Research › peer-review

22 Citations (Scopus)

2011

Assessment of crystalline disorder in cryo-milled samples of indomethacin using atomic pair-wise distribution functions

Bøtker, J. P., Karmwar, P., Strachan, C. J., Cornett, C., Tian, F., Zujovic, Z., Rantanen, J. & Rades, T., 30 Sept 2011, In: International Journal of Pharmaceutics. 417, 1-2, p. 112-119 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

22 Citations (Scopus)

Influence of temperature on solvent-mediated anhydrate-to-hydrate transformation kinetics

Qu, H., Munk, T. P., Cornett, C., Wu, J.-X., Bøtker, J. P., Christensen, L. P., Rantanen, J. T. & Tian, F., Feb 2011, In: Pharmaceutical Research. 28, 2, p. 364-373

Research output: Contribution to journal › Journal article › Research › peer-review

25 Citations (Scopus)

Insights into the early dissolution events of amlodipine using UV imaging and Raman spectroscopy

Boetker, J. P., Savolainen, M., Koradia, V., Tian, F., Rades, T., Müllertz, A., Cornett, C., Rantanen, J. & Østergaard, J., 1 Aug 2011, In: Molecular Pharmaceutics. 8, 4, p. 1372-1380 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

64 Citations (Scopus)

Investigations on the effect of different cooling rates on the stability of amorphous indomethacin

Karmwar, P., Bøtker, J. P., Graeser, K. A., Strachan, C. J., Rantanen, J. & Rades, T., 9 Oct 2011, In: European Journal of Pharmaceutical Sciences. 44, 3, p. 341-350

Research output: Contribution to journal › Journal article › Research › peer-review

40 Citations (Scopus)

Johan Peter Bøtker

Research output

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