In silico product design of pharmaceuticals

Johan Boetker; Dhara Raijada; Johanna Aho; Milad Khorasani; Søren Vinter Søgaard; Lærke Arnfast; Adam Bohr; Magnus Edinger; Jorrit Water; Jukka Rantanen

doi:10.1016/j.ajps.2016.02.010

In silico product design of pharmaceuticals

Johan Boetker, Dhara Raijada, Johanna Aho, Milad Khorasani, Søren Vinter Søgaard, Lærke Arnfast, Adam Bohr, Magnus Edinger, Jorrit Water, Jukka Rantanen

9 Citations (Scopus)

113 Downloads (Pure)

Abstract

The increasing demand for personalized medicine necessitates the production of easily customizable dosage forms. As the number of possible dosage forms may scale toward infinity, their uniqueness requires a versatile production platform and numerical simulation in order to be manufactured efficiently. A mathematical description of these systems is the only feasible approach to manage such diverse properties of different products. However, experimental verification is still essential for evaluation of processability and related concomitant phenomena, such as possible solid state changes that may occur during production and storage.

Original language	Danish
Journal	Asian Journal of Pharmaceutical Sciences
Volume	11
Issue number	4
Pages (from-to)	492–499
Number of pages	8
ISSN	1818-0876
DOIs	https://doi.org/10.1016/j.ajps.2016.02.010
Publication status	Published - 1 Aug 2016

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10.1016/j.ajps.2016.02.010Licence: CC BY-NC-ND

In silico product design of pharmaceuticalsFinal published version, 1.68 MBLicence: CC BY-NC-ND

Cite this

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abstract = "Abstract The increasing demand for personalized medicine necessitates the production of easily customizable dosage forms. As the number of possible dosage forms may scale towards infinity, their uniqueness require a versatile production platform and numerical simulation in order to be manufactured efficiently. A mathematical description of these systems is the only feasible approach to manage such diverse properties of different products. However, experimental verification is still essential for evaluation of processability and related concomitant phenomena, such as possible solid state changes that may occur during production and storage.",

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T1 - In silico product design of pharmaceuticals

AU - Boetker, Johan

AU - Raijada, Dhara

AU - Aho, Johanna

AU - Khorasani, Milad

AU - Søgaard, Søren Vinter

AU - Arnfast, Lærke

AU - Bohr, Adam

AU - Edinger, Magnus

AU - Water, Jorrit

AU - Rantanen, Jukka

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Abstract The increasing demand for personalized medicine necessitates the production of easily customizable dosage forms. As the number of possible dosage forms may scale towards infinity, their uniqueness require a versatile production platform and numerical simulation in order to be manufactured efficiently. A mathematical description of these systems is the only feasible approach to manage such diverse properties of different products. However, experimental verification is still essential for evaluation of processability and related concomitant phenomena, such as possible solid state changes that may occur during production and storage.

AB - Abstract The increasing demand for personalized medicine necessitates the production of easily customizable dosage forms. As the number of possible dosage forms may scale towards infinity, their uniqueness require a versatile production platform and numerical simulation in order to be manufactured efficiently. A mathematical description of these systems is the only feasible approach to manage such diverse properties of different products. However, experimental verification is still essential for evaluation of processability and related concomitant phenomena, such as possible solid state changes that may occur during production and storage.

KW - Personalized medicine

KW - simulation

KW - rheology

KW - imaging

KW - continuous manufacturing

KW - extrusion

U2 - 10.1016/j.ajps.2016.02.010

DO - 10.1016/j.ajps.2016.02.010

M3 - Tidsskriftartikel

SN - 1818-0876

VL - 11

SP - 492

EP - 499

JO - Asian Journal of Pharmaceutical Sciences

JF - Asian Journal of Pharmaceutical Sciences

IS - 4

ER -