Jiri Lukas

Primære forskningsområder

Jiri Lukas studies protein pathways that orchestrate spatial and temporal dynamics of chromosomes during the mammalian cell cycle and after DNA damage, with an emphasis on how are these mechanisms subverted in cancer and other diseases associated with unstable genomes. His long-term interests include high-content microscopy screens for genome caretakers and real-time imaging of signaling and repair proteins.

Aktuel forskning

Recent discoveries from Jiri’s lab include:

• Ubiquitin-driven signalling pathways that barcode chromatin near the DNA lesions to assemble repair and signaling proteins
• Heritability of chromosomal lesions generated on unreplicated DNA during mitosis
• The concept of rate imitation of nodal signaling components as a mechanism to confine repair reactions and posttranslational chromatin modifications to damaged loci in the genome

CV

Jiri Lukas

Current position 
May 2012–:

Executive director, Novo Nordisk Foundation Center for Protein Research (CPR), Faculty of Health and Medical Sciences, University of Copenhagen

Previous positions 
2005-2012:

Director and head of research, Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark

1993-2005:

Senior scientist and group leader, Danish Cancer Society, Copenhagen, Denmark

1992-1993: 

Differentiation Program (Giulio Draetta lab), EMBL, Heidelberg, Germany. 
Research topic: cell cycle regulation, mechanisms of cancer

1991-1992:

Researcher, Institute of Hematology and Blood Transfusion, Prague, Czech Republic

1990, 1991:

Department of Biochemistry (Paul Nurse lab), Oxford, UK. 
Research topic: cell cycle regulation

1990-1991:

Researcher, Masaryk Institute of Oncology, Brno, Czech Republic

Education
1987-1990:

PhD in Zoology, Institute of Systematic and Ecological Biology, Brno, Czech Republic

1981-1986:

D.V.M. in Veterinary Medicine, Veterinary University, Brno, Czech Republic

Research awards

2016:    Fernström Foundation Grand Nordic Prize
2014:    Leopold Griffuel Prize
2014:    Elected member of the European Academy of Cancer Sciences
2012:    Elected member of the Royal Danish Academy of Sciences and Letters
2010:    Danish Society for Cancer Research Award
2008:    Danish Cancer Society Senior Research Prize
2005:    Honorary member of the Learned Society of the Czech Republic
2003:    G. J. Mendel Honorary Medal
2003:    Novo Nordisk Foundation Prize
2002:    Alfred Benzons Foundation Prize
2002:    Elected EMBO Member
1995:    Young Danish Cancer Researcher Prize