Jannick Prentø

Research output

Research output per year 2008 2009 2011 2012 2013 2014 2018 2019 2019

• 27 Journal article
• 3 Patent
• 1 Book chapter
• 1 Review

Research output per year

Research output per year

Search results

• 2019

  Broadly neutralizing antibodies from an individual that naturally cleared multiple hepatitis c virus infections uncover molecular determinants for E2 targeting and vaccine design

  Keck, Z. Y., Pierce, B. G., Lau, P., Lu, J., Wang, Y., Underwood, A., Bull, R. A., Prentoe, J., Velázquez-Moctezuma, R., Walker, M. R., Luciani, F., Guest, J. D., Fauvelle, C., Baumert, T. F., Bukh, J., Lloyd, A. R. & Foung, S. K. H., 2019, In: P L o S Pathogens. 15, 5, 28 p., e1007772.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Broadly Neutralizing Antibodies 100%
  • Hepatitis Viruses 89%
  • hepatitis 89%
  • vaccine development 88%
  • neutralizing antibodies 82%
  19 Citations (Scopus)

  21 Downloads (Pure)

• Genetic and structural insights into broad neutralization of hepatitis C virus by human V_H1-69 antibodies

  Tzarum, N., Giang, E., Kong, L., He, L., Prentoe, J., Augestad, E., Hua, Y., Castillo, S., Lauer, G. M., Bukh, J., Zhu, J., Wilson, I. A. & Law, M., 2019, In: Science Advances. 5, 1, 12 p., eaav1882.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hepacivirus 100%
  • Broadly Neutralizing Antibodies 75%
  • Antibodies 59%
  • Vaccines 26%
  • Immunoglobulin Isotypes 21%
  37 Citations (Scopus)

  80 Downloads (Pure)

• Hepatitis C Virus–Escape Studies for Human Monoclonal Antibody AR4A Reveal Isolate-Specific Resistance and a High Barrier to Resistance

  Velázquez-moctezuma, R., Galli, A., Law, M., Bukh, J. & Prentoe, J., 1 Jan 2019, In: The Journal of Infectious Diseases. 219, 1, p. 68-79

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hepatitis C 100%
  • Hepacivirus 90%
  • Monoclonal Antibodies 71%
  • Genotype 69%
  • Vaccines 54%
  6 Citations (Scopus)

• Hepatitis C virus escape studies of human antibody AR3a reveal a high barrier to resistance and novel insights on viral antibody evasion mechanisms

  Velázquez-Moctezuma, R., Galli, A., Law, M., Bukh, J. & Prentoe, J., 2019, In: Journal of Virology. 93, 4, e0190918.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • viral antibodies 100%
  • Viral Antibodies 86%
  • Hepatitis C virus 86%
  • Hepacivirus 55%
  • vaccine development 49%
  11 Citations (Scopus)

• Hypervariable region 1 and N-linked glycans of hepatitis C regulate virion neutralization by modulating envelope conformations

  Prentoe, J., Velázquez-Moctezuma, R., Augestad, E. H., Galli, A., Wang, R., Law, M., Alter, H. & Bukh, J., 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 20, p. 10039-10047 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hepatitis C 100%
  • Virion 93%
  • Polysaccharides 91%
  • Hepacivirus 64%
  • Scavenger Receptors 36%
  17 Citations (Scopus)

• In vitro neutralization assay using cultured hepatitis C virus

  Prentoe, J. & Bukh, J., 2019, Hepatitis C Virus Protocols. Humana Press, p. 433-439 7 p. (Methods in Molecular Biology, Vol. 1911).

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  • Hepacivirus 100%
  • In Vitro Techniques 47%
  • Antibodies 44%
  • Vaccines 20%
  • Monoclonal Antibodies 19%
  4 Citations (Scopus)
• 2018

  High density Huh7.5 cell hollow fiber bioreactor culture for high-yield production of hepatitis C virus and studies of antivirals

  Pihl, A. F., Offersgaard, A. F., Mathiesen, C. K., Prentoe, J., Fahnøe, U., Krarup, H., Bukh, J. & Gottwein, J. M., 2018, In: Scientific Reports. 8, 1, 13 p., 17505.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Bioreactors 100%
  • Hepacivirus 77%
  • Antiviral Agents 71%
  • Cell Count 62%
  • Cell Culture Techniques 21%
  2 Citations (Scopus)

  53 Downloads (Pure)

• Hypervariable Region 1 in Envelope Protein 2 of Hepatitis C Virus: A Linchpin in Neutralizing Antibody Evasion and Viral Entry

  Prentoe, J. & Bukh, J., 27 Sept 2018, In: Frontiers in Immunology. 9, 11 p., 2146.

  Research output: Contribution to journal › Review › peer-review

  • Hepatitis A virus 100%
  • Hepatitis C 78%
  • Neutralizing Antibodies 76%
  • Hepacivirus 71%
  • CD36 Antigens 66%
  24 Citations (Scopus)

  53 Downloads (Pure)

• Identification of Piperazinylbenzenesulfonamides as New Inhibitors of Claudin-1 Trafficking and Hepatitis C Virus Entry

  Riva, L., Song, O., Prentoe, J., Helle, F., L'homme, L., Gattolliat, C-H., Vandeputte, A., Feneant, L., Belouzard, S., Baumert, T. F., Asselah, T., Bukh, J., Brodin, P., Cocquerel, L., Rouille, Y. & Dubuisson, J., 1 May 2018, In: Journal of Virology. 92, 10, 19 p., e01982-17.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hepatitis C virus 100%
  • Claudin-1 98%
  • Virus Internalization 85%
  • Hepacivirus 63%
  • cAMP-dependent protein kinase 35%
  7 Citations (Scopus)
• 2017

  Applying antibody-sensitive hypervariable region 1-deleted hepatitis C virus to the study of escape pathways of neutralizing human monoclonal antibody AR5A

  Velazquez-Moctezuma, R., Law, M., Bukh, J. & Prentoe, J., Feb 2017, In: PLOS Pathogens. 13, 2, 29 p., 1006214.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hepatitis C virus 100%
  • neutralization 71%
  • Hepacivirus 63%
  • monoclonal antibodies 61%
  • Monoclonal Antibodies 50%
  15 Citations (Scopus)

  79 Downloads (Pure)
• 2016

  HVR1-mediated antibody evasion of highly infectious in vivo adapted HCV in humanised mice

  Prentoe, J., Verhoye, L., Moctezuma, R. V., Buysschaert, C., Farhoudi, A., Wang, R., Alter, H., Meuleman, P. & Bukh, J., 1 Dec 2016, In: Gut. 65, 12, p. 1988-1997 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Genomic Instability 100%
  • Genotype 97%
  • Viruses 91%
  • Mutation 76%
  • Antibodies 75%
  23 Citations (Scopus)

  76 Downloads (Pure)

• Hypervariable Region 1 Shielding of Hepatitis C Virus Is a Main Contributor to Genotypic Differences in Neutralization Sensitivity

  Prentoe, J., Velazquez-Moctezuma, R., Foung, S. K. H., Law, M. & Bukh, J., 1 Dec 2016, In: Hepatology. 64, 6, p. 1881-1892 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hepacivirus 100%
  • Viruses 61%
  • Epitopes 52%
  • Monoclonal Antibodies 45%
  • Genotype 33%
  43 Citations (Scopus)
• 2015

  Adaptive Mutations Enhance Assembly and Cell-to-Cell Transmission of a High-Titer Hepatitis C Virus Genotype 5a Core-NS2 JFH1-Based Recombinant

  Mathiesen, C. K., Prentoe, J., Meredith, L. W., Jensen, T. B., Krarup, H., McKeating, J. A., Gottwein, J. M. & Bukh, J., Aug 2015, In: Journal of Virology. 89, 15, p. 7758-7775 18 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hepatitis C virus 100%
  • Hepacivirus 63%
  • Genotype 49%
  • mutation 47%
  • Viruses 45%
  15 Citations (Scopus)
• 2014

  Breadth of neutralization and synergy of clinically relevant human monoclonal antibodies against HCV genotypes 1a, 1b, 2a, 2b, 2c, and 3a

  Carlsen, T. H. R., Pedersen, J., Prentoe, J. C., Giang, E., Keck, Z-Y., Mikkelsen, L. S., Law, M., Foung, S. K. H. & Bukh, J., 1 Nov 2014, In: Hepatology. 60, 5, p. 1551-62 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hepacivirus 100%
  • Monoclonal Antibodies 78%
  • Genotype 77%
  • Inhibitory Concentration 50 29%
  • N-(8-aminooctyl)-5-iodonaphthalene-1-sulfonamide 20%
  58 Citations (Scopus)

• Hepatitis C virus expressing reporter tagged NS5A protein: Patent #: 8,772,022

  Gottwein, J. M., Scheel, T. K. H., Bukh, J., Prentø, J. C. & Jensen, T. B., 8 Jul 2014, IPC No. C12N 15/00 (20060101); C12N 5/00 (20060101); C12N 7/00 (20060101); C12N 15/64 (20060101); A61K 39/29 (20060101); C12N 7/01 (20060101), Patent No. WO2010/037403, 8 Apr 2010, Priority date 5 Oct 2009, Priority No. PCT/DK2009/050263

  Research output: Patent

  • 5' Untranslated Regions 100%
  • Hepacivirus 95%
  • Genotype 73%
  • Proteins 37%
  • Reporter Genes 34%

• Hypervariable region 1 deletion and required adaptive envelope mutations confer decreased dependency on scavenger receptor class B type I and low-density lipoprotein receptor for hepatitis C virus

  Prentoe, J., Serre, S. B. N., Ramirez, S., Nicosia, A. & Bukh, J., Feb 2014, In: Journal of Virology. 88, 3, p. 1725-39 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hepatitis C virus 100%
  • CD36 Antigens 99%
  • low density lipoprotein receptors 92%
  • LDL Receptors 80%
  • Hepacivirus 63%
  33 Citations (Scopus)

• Infectious genotype 1a, 1b, 2a, 2b, 3a, 5a, 6a and 7a hepatitis C virus lacking the hypervariable region 1 (HVR1): Patent #: 8,846,891

  Prentø, J. C., Gottwein, J. M., Scheel, T. K. H., Bukh, J. & Jensen, T. B., 30 Sept 2014, IPC No. C07H 21/04 (20060101); C07H 21/02 (20060101), Patent No. WO2010/022727, 4 Mar 2010, Priority date 7 Aug 2009, Priority No. PCT/DK2009/050197

  Research output: Patent

  • N-(8-aminooctyl)-5-iodonaphthalene-1-sulfonamide 100%
  • Inventors 85%
  • Hepacivirus 49%
  • Genotype 38%
  • Viruses 35%

• Production and characterization of high-titer serum-free cell culture grown hepatitis C virus particles of genotype 1-6

  Mathiesen, C. K., Jensen, T. B., Prentoe, J., Krarup, H., Nicosia, A., Law, M., Bukh, J. & Gottwein, J. M., Jun 2014, In: Virology. 458-459, p. 190-208 19 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Virion 100%
  • Hepacivirus 97%
  • Cell Culture Techniques 79%
  • Genotype 74%
  • Serum 47%
  10 Citations (Scopus)
• 2013

  Analysis of hepatitis C virus core/NS5A protein co-localization using novel cell culture systems expressing core-NS2 and NS5A of genotypes 1-7

  Galli, A., Scheel, T. K. H., Prentoe, J. C., Mikkelsen, L. S., Gottwein, J. M. & Bukh, J., Oct 2013, In: The Journal of general virology. 94, Pt 10, p. 2221-35 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hepatitis C virus nucleocapsid protein 100%
  • Cell Culture Techniques 50%
  • Genotype 47%
  • Hepacivirus 41%
  • Virus Assembly 19%
  14 Citations (Scopus)

• Cooperativity in virus neutralization by human monoclonal antibodies to two adjacent regions located at the amino terminus of hepatitis C virus E2 glycoprotein

  Keck, Z., Wang, W., Wang, Y., Lau, P., Carlsen, T. H. R., Prentoe, J., Xia, J., Patel, A. H., Bukh, J. & Foung, S. K. H., Jan 2013, In: Journal of Virology. 87, 1, p. 37-51 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hepatitis C virus glycoprotein E2 100%
  • Hepatitis C virus 83%
  • neutralization tests 69%
  • neutralization 53%
  • monoclonal antibodies 51%
  90 Citations (Scopus)

• Efficient cell culture system for hepatitis C virus genotype 1a and 1b: Patent #: 8,563,706

  Scheel, T. K. H., Gottwein, J. M., Prentø, J. C., Jensen, T. B. & Bukh, J., 22 Oct 2013, IPC No. C07H 21/00 (20060101); A61K 39/29 (20060101); A61K 39/12 (20060101); A61K 39/295 (20060101); C12N 7/00 (20060101), Patent No. WO2009/080053, 2 Jul 2009, Priority date 19 Dec 2008, Priority No. PCT/DK2008/050333

  Research output: Patent

  • Inventors 100%
  • Hepacivirus 95%
  • Cell Culture Techniques 78%
  • Genotype 74%
  • Mutation 34%

• Neutralization resistance of hepatitis C virus can be overcome by recombinant human monoclonal antibodies

  Pedersen, J. L., Carlsen, T. H. R., Prentoe, J., Ramirez, S., Jensen, T. B., Forns, X., Alter, H., Foung, S. K. H., Law, M., Gottwein, J., Weis, N. & Bukh, J., Nov 2013, In: Hepatology. 58, 5, p. 1587-1597 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hepacivirus 100%
  • Monoclonal Antibodies 78%
  • Genotype 67%
  • N-(8-aminooctyl)-5-iodonaphthalene-1-sulfonamide 50%
  • Neutralizing Antibodies 27%
  31 Citations (Scopus)
• 2012

  Analysis of functional differences between hepatitis C virus NS5A of genotypes 1-7 in infectious cell culture systems

  Scheel, T. K. H., Prentoe, J., Carlsen, T. H. R., Mikkelsen, L. S., Gottwein, J. M. & Bukh, J., May 2012, In: P L o S Pathogens. 8, 5, p. 1-16 17 p., e1002696.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hepatitis C virus 100%
  • Hepacivirus 63%
  • cell culture 54%
  • Cell Culture Techniques 52%
  • Genotype 49%
  33 Citations (Scopus)

• Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus

  Giang, E., Dorner, M., Prentoe, J. C., Dreux, M., Evans, M. J., Bukh, J., Rice, C. M., Ploss, A., Burton, D. R. & Law, M., 17 Apr 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 16, p. 6205-10 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Broadly Neutralizing Antibodies 100%
  • Hepacivirus 65%
  • Glycoproteins 60%
  • Vaccines 30%
  • B-Lymphocyte Epitopes 27%
  237 Citations (Scopus)

• Human monoclonal antibodies to a novel cluster of conformational epitopes on HCV E2 with resistance to neutralization escape in a genotype 2a isolate

  Keck, Z., Xia, J., Wang, Y., Wang, W., Krey, T., Prentoe, J., Carlsen, T., Li, A. Y-J., Patel, A. H., Lemon, S. M., Bukh, J., Rey, F. A. & Foung, S. K. H., Apr 2012, In: P L o S Pathogens. 8, 4, 21 p., e1002653.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hepatitis C virus 100%
  • neutralization 71%
  • epitopes 66%
  • Hepacivirus 63%
  • monoclonal antibodies 61%
  155 Citations (Scopus)
• 2011

  Hepatitis C virus expressing flag-tagged envelope protein 2 has unaltered infectivity and density, is specifically neutralized by flag antibodies and can be purified by affinity chromatography

  Prentø, J. C. & Bukh, J., 20 Jan 2011, In: Virology. 409, 2, p. 148-55

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Affinity Chromatography 100%
  • Hepacivirus 86%
  • Viruses 62%
  • Antibodies 51%
  • Hepatitis C virus glycoprotein E2 46%
  18 Citations (Scopus)

• Hypervariable region 1 differentially impacts viability of hepatitis C virus strains of genotypes 1 to 6 and impairs virus neutralization

  Prentø, J. C., Jensen, T. B., Meuleman, P., Serre, S., Scheel, T. K. H., Leroux-Roels, G., Gottwein, J. & Bukh, J., Mar 2011, In: Journal of Virology. 85, 5, p. 2224-34 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hepatitis C virus 100%
  • neutralization tests 83%
  • Hepacivirus 63%
  • neutralization 62%
  • viability 51%
  112 Citations (Scopus)

• Neutralizing monoclonal antibodies against hepatitis C virus E2 protein bind discontinuous epitopes and inhibit infection at a postattachment step

  Sabo, M. C., Luca, V. C., Prentoe, J., Hopcraft, S. E., Blight, K. J., Yi, M., Lemon, S. M., Ball, J. K., Bukh, J., Evans, M. J., Fremont, D. H. & Diamond, M. S., Jul 2011, In: Journal of Virology. 85, 14, p. 7005-19 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hepatitis C virus 100%
  • neutralizing antibodies 79%
  • Neutralizing Antibodies 68%
  • epitopes 66%
  • Hepacivirus 63%
  101 Citations (Scopus)
• 2009

  DELETION OF HYPERVARIABLE REGION 1 (HVR1) OF E2 FROM HCV GENOTYPES 1-6 HAS DIFFERENTIAL EFFECT ON INFECTIVITY IN VITRO AND CAUSES INCREASED SUSCEPTIBILITY TO NEUTRALIZATION

  Prentoe, J., Gottwein, J. M., Scheel, T. K. H., Jensen, T. B., Serre, S. & Bukh, J., 2009, In: Journal of Hepatology. 50, p. S34-S34

  Research output: Contribution to journal › Journal article › Research › peer-review

• Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: role of CD81 and scavenger receptor class B type I and effect of antiviral drugs

  Gottwein, J. M., Scheel, T. K. H., Jensen, T. B., Lademann, J. B., Prentoe, J. C., Knudsen, M. L., Hoegh, A. M. & Bukh, J., 2009, In: Hepatology. 49, 2, p. 364-77 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • CD36 Antigens 100%
  • Hepacivirus 64%
  • Antiviral Agents 59%
  • Cell Culture Techniques 52%
  • Genotype 49%
  281 Citations (Scopus)

• MONOCISTRONIC HEPATITIS C REPORTER VIRUS RECOMBINANTS OF ALL MAJOR GENOTYPES EXPRESSING ENHANCED GREEN FLUORESCENT PROTEIN TAGGED NS5A PROTEIN

  Gottwein, J. M., Lademann, J. B., Scheel, T. K. H., Jensen, T. B., Prentoe, J. C. & Bukh, J., 2009, In: Journal of Hepatology. 50, p. S33-S33

  Research output: Contribution to journal › Journal article › Research › peer-review
• 2008

  Development of JFH1-based cell culture systems for hepatitis C virus genotype 4a and evidence for cross-genotype neutralization

  Scheel, T. K. H., Gottwein, J. M., Jensen, T. B., Prentø, J. C., Høegh, A. M., Alter, H. J., Eugen-Olsen, J. & Bukh, J., 2008, In: Proceedings of the National Academy of Science of the United States of America. 105, 3, p. 997-1002 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  149 Citations (Scopus)