Jakob Benedict Seidelin

2020

Crohn's disease with progressive renal impairment

Seidelin, J. B., Riis, L. B. & Butt, R. A., Jan 2020, In: Gastroenterology.

Research output: Contribution to journal › Journal article › Research › peer-review

2019

Fluorescence-based tracing of transplanted intestinal epithelial cells using confocal laser endomicroscopy

Bergenheim, F., Seidelin, J. B., Pedersen, M. T., Mead, B. E., Jensen, K. B., Karp, J. M. & Nielsen, O. H., 27 May 2019, In: Stem Cell Research & Therapy. 10, 1, p. 1-12 12 p., 148.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

20 Downloads (Pure)

2018

Characterization of the enhancer and promoter landscape of inflammatory bowel disease from human colon biopsies

Boyd, M., Thodberg, M., Vitezic, M., Lange, J. B., Vitting-Seerup, K., Chen, Y., Coskun, M., Li, Y., Lo, B. Z. S., Klausen, P., Schweiger, P., Pedersen, A. G., Rapin, N. P. J-P., Skovgaard, K., Dahlgaard, K., Andersson, R., Terkelsen, T. B., Lilje, B., Troelsen, J. T., Petersen, A. M., & 7 othersJensen, K. B., Gögenur, I., Thielsen, P., Seidelin, J. B., Nielsen, O. H., Bjerrum, J. T. & Sandelin, A. G., 1 Dec 2018, In: Nature Communications. 9, 19 p., 1661.

Research output: Contribution to journal › Journal article › Research › peer-review

20 Citations (Scopus)

120 Downloads (Pure)

COX-2-PGE2 Signaling Impairs Intestinal Epithelial Regeneration and Associates with TNF Inhibitor Responsiveness in Ulcerative Colitis

Li, Y., Soendergaard, C., Bergenheim, F. H., Aronoff, D. M., Milne, G., Riis, L. B., Seidelin, J. B., Jensen, K. B. & Nielsen, O. H., Oct 2018, In: EBioMedicine. 36, p. 497-507

Research output: Contribution to journal › Journal article › Research › peer-review

19 Citations (Scopus)

43 Downloads (Pure)

Putative biomarkers of vedolizumab resistance and underlying inflammatory pathways involved in IBD

Soendergaard, C., Seidelin, J. B., Steenholdt, C. & Nielsen, O. H., 2018, In: B M J Open Gastroenterology. 5, 1, e000208.

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

47 Downloads (Pure)

2017

Asymptomatic carriers contribute to nosocomial Clostridium difficile infection: a cohort study of 4508 patients

Blixt, T., Gradel, K. O., Homann, C., Seidelin, J. B., Schønning, K., Lester, A., Houlind, J., Stangerup, M., Gottlieb, M. & Knudsen, J. D., 1 Apr 2017, In: Gastroenterology. 152, 5, p. 1031-1041.e2

Research output: Contribution to journal › Journal article › Research › peer-review

32 Citations (Scopus)

Culturing human intestinal stem cells for regenerative applications in the treatment of inflammatory bowel disease

Holmberg, F. E., Seidelin, J. B., Yin, X., Mead, B. E., Tong, Z., Li, Y., Karp, J. M. & Nielsen, O. H., May 2017, In: EMBO Molecular Medicine. 9, 5, p. 558-570 13 p.

Research output: Contribution to journal › Review › peer-review

40 Citations (Scopus)

85 Downloads (Pure)

Primary monocytes derived from ulcerative colitis show no difference in the TNF-alpha-induced immune response among responders and primary non-responders to infliximab

Li, Y., Jensen, K. B., Seidelin, J. & Nielsen, O. H., Sept 2017, In: Journal of Gastroenterology and Hepatology. 32, S3, p. 138-138 P-0750.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Relation between NOD2 genotype and changes in innate signaling in Crohn's disease on mRNA and miRNA levels

Chen, Y., Salem, M., Boyd, M., Bornholdt, J., Li, Y., Coskun, M., Seidelin, J. B., Sandelin, A. & Nielsen, O. H., 2017, In: npj Genomic Medicine. 2, 11 p., 3.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

21 Downloads (Pure)

2016

Objective Quantification of Immune Cell Infiltrates and Epidermal Proliferation in Psoriatic Skin: A Comparison of Digital Image Analysis and Manual Counting

Soendergaard, C., Nielsen, O. H., Skak, K., Røpke, M. A., Seidelin, J. B. & Kvist, P. H., 1 Jul 2016, In: Applied Immunohistochemistry & Molecular Morphology. p. 1-6 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

Systemic and intestinal levels of factor XIII-A: the impact of inflammation on expression in macrophage subtypes

Søndergaard, C., Kvist, P. H., Seidelin, J. B., Pelzer, H. & Nielsen, O. H., 1 Aug 2016, In: Journal of Gastroenterology. 51, 8, p. 796-807 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Will novel oral formulations change the management of inflammatory bowel disease?

Nielsen, O. H., Seidelin, J. B., Ainsworth, M. A. & Coskun, M., 2 Jun 2016, In: Expert Opinion on Investigational Drugs. 25, 6, p. 709-718 10 p.

Research output: Contribution to journal › Review › peer-review

20 Citations (Scopus)

2015

Alpha-1 antitrypsin and granulocyte colony-stimulating factor as serum biomarkers of disease severity in ulcerative colitis

Soendergaard, C., Nielsen, O. H., Seidelin, J. B., Kvist, P. H. & Bjerrum, J. T., 3 Mar 2015, In: Inflammatory Bowel Diseases. 21, 5, p. 1077-88 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

ATG16L1: A multifunctional susceptibility factor in Crohn disease

Salem, M., Ammitzboell, M., Nys, K., Seidelin, J. B. & Nielsen, O. H., 3 Apr 2015, In: Autophagy. 11, 4, p. 585-94 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

54 Citations (Scopus)

Cellular inhibitor of apoptosis protein 2 controls human colonic epithelial restitution, migration, and Rac1 activation

Seidelin, J. B., Larsen, S., Linnemann, D., Vainer, B., Coskun, M., Troelsen, J. T. & Nielsen, O. H., 15 Jan 2015, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 308, 2, p. G92-G99 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

GM6001 Increases Anastomotic Leakage following Colonic Obstruction Possibly by Impeding Epithelialization

Rehn, M., Krarup, P-M., Christensen, L. H., Seidelin, J. B., Ågren, M. S. & Syk, I., 1 Dec 2015, In: Surgical Infections. 16, 6, p. 702-8 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

Impact of T300A Variant of ATG16L1 on Antibacterial Response, Risk of Culture Positive Infections, and Clinical Course of Crohn's Disease

Salem, M., Nielsen, O. H., Nys, K., Yazdanyar, S. & Seidelin, J. B., 5 Nov 2015, In: Clinical and Translational Gastroenterology. 6, 9 p., e122.

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

Regulation of antiapoptotic and cytoprotective pathways in colonic epithelial cells in ulcerative colitis

Seidelin, J. B., 27 Nov 2015, In: Scandinavian Journal of Gastroenterology. 50 , Suppl 1, p. 1-29 29 p.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

Species-specific engagement of human nucleotide oligomerization domain 2 (NOD)2 and Toll-like receptor (TLR) signalling upon intracellular bacterial infection: role of Crohn's associated NOD2 gene variants

Salem, M., Seidelin, J. B., Eickhardt-Dalbøge, S. R., Alhede, M., Rogler, G. & Nielsen, O. H., 1 Mar 2015, In: Clinical and Experimental Immunology. 179, 3, p. 426-34 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

20 Citations (Scopus)

2014

Identification of TNF-α-responsive promoters and enhancers in the intestinal epithelial cell model Caco-2

Boyd, M., Coskun, M., Lilje, B., Andersson, R., Hoof, I., Lange, J. B., Dahlgaard, K., Olsen, J., Vitezic, M., Bjerrum, J. T., Seidelin, J. B., Nielsen, O. H., Troelsen, J. & Sandelin, A. G., 1 Dec 2014, In: D N A Research. 21, 6, p. 569-583 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

1750 Downloads (Pure)

IL-33 promotes GATA-3 polarization of gut-derived T cells in experimental and ulcerative colitis

Seidelin, J. B., Coskun, M., Kvist, P. H., Holm, T. L., Holgersen, K. & Nielsen, O. H., Feb 2014, In: Journal of Gastroenterology. 50, 2, p. 180-190 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

37 Citations (Scopus)

Inhibitors of apoptosis (IAPs) regulate intestinal immunity and inflammatory bowel disease (IBD) inflammation

Pedersen, J., LaCasse, E. C., Seidelin, J. B., Coskun, M. & Nielsen, O. H., 1 Nov 2014, In: Trends in Molecular Medicine. 20, 11, p. 652-65 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

69 Citations (Scopus)

2013

Biological treatment of Crohn's disease

Nielsen, O. H., Bjerrum, J. T., Seidelin, J. B., Nyberg, C. & Ainsworth, M., Jan 2013, In: Digestive Diseases. 30 Suppl 3, p. 121-33 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Caspase 14 does not influence intestinal epithelial cell differentiation

Seidelin, J. B., Sträter, J. & Nielsen, O. H., Mar 2013, In: Cell Death and Differentiation. 20, 3, p. 524

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

Colitis ulcerosa

Translated title of the contribution: Ulcerative colitisNielsen, O. H., Jess, T., Bjerrum, J. T. & Seidelin, J. B., May 2013, In: Ugeskrift for Laeger. 175, 20, p. 1412-6 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

ERK controls epithelial cell death receptor signalling and cellular FLICE-like inhibitory protein (c-FLIP) in ulcerative colitis

Seidelin, J. B., Coskun, M., Vainer, B., Riis, L., Soendergaard, C. & Nielsen, O. H., Jul 2013, In: Journal of Molecular Medicine. 91, 7, p. 839-49 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

14 Citations (Scopus)

miR-20b, miR-98, miR-125b-1, and let-7e as new potential diagnostic biomarkers in ulcerative colitis

Coskun, M., Bjerrum, J. T., Seidelin, J. B., Troelsen, J., Olsen, J. & Nielsen, O. H., 21 Jul 2013, In: World Journal of Gastroenterology. 19, 27, p. 4289-99 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

59 Citations (Scopus)

Mucosal healing in ulcerative colitis: pathophysiology and pharmacology

Seidelin, J. B., Coskun, M. & Nielsen, O. H., 2013, In: Advances in Clinical Chemistry. 59, p. 101-23 23 p.

Research output: Contribution to journal › Journal article › Research › peer-review

26 Citations (Scopus)

Muramyl dipeptide responsive pathways in Crohn's disease: from NOD2 and beyond

Salem, M., Seidelin, J. B., Rogler, G. & Nielsen, O. H., Sept 2013, In: Cellular and Molecular Life Sciences. 70, p. 3391-3404

Research output: Contribution to journal › Journal article › Research › peer-review

19 Citations (Scopus)

Noninfectious & noninflammatory bowel disease colitis

Nielsen, O. H., Bjerrum, J. T. & Seidelin, J. B., 1 Mar 2013, Advances in the Management of Inflammatory Bowel Disease. Future Medicine Ltd., p. 33-49 17 p.

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Tissue regenerating functions of coagulation factor XIII

Soendergaard, C., Kvist, P. H., Seidelin, J. B. & Nielsen, O. H., May 2013, In: Journal of Thrombosis and Haemostasis.

Research output: Contribution to journal › Journal article › Research › peer-review

18 Citations (Scopus)

2012

MicroRNAs in inflammatory bowel disease--pathogenesis, diagnostics and therapeutics

Coskun, M., Bjerrum, J. T., Seidelin, J. B. & Nielsen, O. H., 2012, In: World Journal of Gastroenterology. 18, 34, p. 4629-34 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

66 Citations (Scopus)

Outcome after discontinuation of infliximab in patients with inflammatory bowel disease in clinical remission: an observational Danish single center study

Steenholdt, C., Molazahi, A., Ainsworth, M. A., Brynskov, J., Thomsen, O. Ø. & Seidelin, J. B., May 2012, In: Scandinavian Journal of Gastroenterology.

Research output: Contribution to journal › Journal article › Research › peer-review

73 Citations (Scopus)

pcaGoPromoter--an R package for biological and regulatory interpretation of principal components in genome-wide gene expression data

Hansen, M., Gerds, T. A., Nielsen, O. H., Seidelin, J. B., Troelsen, J. T. & Olsen, J., 27 Feb 2012, In: P L o S One. 7, 2, p. e32394

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

2011

MAP kinases in inflammatory bowel disease

Coskun, M., Olsen, J., Seidelin, J. B. & Nielsen, O. H., 18 Mar 2011, In: Clinica Chimica Acta. 412, 7-8, p. 513-20 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

101 Citations (Scopus)

Pathogenesis and biomarkers of carcinogenesis in ulcerative colitis

Thorsteinsdottir, S., Gudjonsson, T., Nielsen, O. H., Vainer, B. & Seidelin, J. B., Jul 2011, In: Nature Reviews. Gastroenterology & Hepatology. 8, 7, p. 395-404 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

54 Citations (Scopus)

Use of biological molecules in the treatment of inflammatory bowel disease

Nielsen, O. H., Seidelin, J. B., Munck, L. K. & Rogler, G., Jul 2011, In: Journal of Internal Medicine. 270, 1, p. 15-28 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

33 Citations (Scopus)

2010

IL-33 is upregulated in colonocytes of ulcerative colitis

Seidelin, J. B., Bjerrum, J. T., Coskun, M., Widjaya, B., Vainer, B., Nielsen, O. H., Seidelin, J. B., Bjerrum, J. T., Coskun, M., Widjaya, B., Vainer, B. & Nielsen, O. H., 18 Jan 2010, In: Immunology Letters. 128, 1, p. 80-5 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

110 Citations (Scopus)

2009

Aeromedical transport after acute myocardial infarction

Seidelin, J. B., Bruun, N. E. & Nielsen, H., 2009, In: Journal of Travel Medicine. 16, 2, p. 96-100 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

Betydningen af mikroribonukleinsyre for sygdomsudvikling

Translated title of the contribution: The role of micro-ribonucleic acid in disease developmentWidjaya, B., Seidelin, J. B., Olsen, J. & Nielsen, O. H., 16 Nov 2009, In: Ugeskrift for Laeger. 171, 47, p. 3441-4 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Diagnosis of ulcerative colitis before onset of inflammation by multivariate modeling of genome-wide gene expression data

Olsen, J., Gerds, T. A., Seidelin, J. B., Csillag, C., Bjerrum, J. T., Troelsen, J. T. & Nielsen, O. H., 2009, In: Inflammatory Bowel Diseases. 15, 7, p. 1032-8 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

71 Citations (Scopus)

Epithelial apoptosis: cause or consequence of ulcerative colitis?

Seidelin, J. B. & Nielsen, O. H., 2009, In: Scandinavian Journal of Gastroenterology. 44, 12, p. 1429-34 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

20 Citations (Scopus)

Evidence for impaired CARD15 signalling in Crohn's disease without disease linked variants

Seidelin, J. B., Broom, O. J., Olsen, J. & Nielsen, O. H., 2009, In: PLoS ONE. 4, 11, p. e7794

Research output: Contribution to journal › Journal article › Research › peer-review

16 Citations (Scopus)

Samtidig leptospirose og salmonellainfektion

Translated title of the contribution: Concurrent leptospirosis and salmonella infectionRönsholt, F. F., Seidelin, J. B. & Villumsen, S., 4 May 2009, In: Ugeskrift for Laeger. 171, 19, p. 1607-9 3 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

2008

Attenuated apoptosis response to Fas-ligand in active ulcerative colitis

Seidelin, J. B. & Nielsen, O. H., Dec 2008, In: Inflammatory Bowel Diseases. 14, 12, p. 1623-9 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

21 Citations (Scopus)

2007

Upregulation of cIAP2 in regenerating colonocytes in ulcerative colitis

Seidelin, J. B., Vainer, B., Andresen, L. & Nielsen, O. H., 2007, In: Virchows Archiv. 451, 6, p. 1031-1038 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

18 Citations (Scopus)

2006

Expression profiling of apoptosis-related genes in enterocytes isolated from patients with ulcerative colitis

Seidelin, J. B. & Nielsen, O. H., Jul 2006, In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 114, 7-8, p. 508-17 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Regulering af cytokindannelse ved inflammatoriske tarmsygdomme

Translated title of the contribution: Regulation of cytokine production in inflammatory bowel diseaseFerrero-Miliani, L., Seidelin, J. B. & Nielsen, O. H., 8 May 2006, In: Ugeskrift for Laeger. 168, 19, p. 1847-50 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Transdermal nikotinbehandling af colitis ulcerosa: gennemgang af et Cochrane-review

Translated title of the contribution: Transdermal nicotine treatment of ulcerative colitis: a survey of a Cochrane reviewSeidelin, J. B. & Nielsen, O. H., 13 Feb 2006, In: Ugeskrift for Laeger. 168, 7, p. 674-7 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

1 Citation (Scopus)

2005

Continuous cytokine exposure of colonic epithelial cells induces DNA damage

Seidelin, J. B. & Nielsen, O. H., Mar 2005, In: European journal of gastroenterology & hepatology. 17, 3, p. 363-9 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

20 Citations (Scopus)

Jakob Benedict Seidelin

Research output

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