Research output per year
Research output per year
Personal profile
Short presentation
H. Lundbeck A/S is developing treatments targeting neurodegenerative diseases. Several of the drugs in Lundbecks pipeline are monoclonal antibodies (mAbs). My task is to identify the epitope of several of these mAbs by employing the highly sensitive analytical method hydrogen/deuterium exchange followed by mass spectrometry.
Furthermore, in the Protein Analysis Group, Department of Pharmacy, University of Copenhagen my work focuses on development and improvement of mass spectrometric methods for probing the primary and higher-order structure of proteins and protein-complexes, especially HDX-MS.
Group webpage:
www.pharmacy.ku.dk/research/section_analytical_biosciences/protein_analysis-lab/
Primary fields of research
- Analysis of the primary and higher-order structure of proteins by LC-MS/MS
- Identification of protein-protein interaction sites
- Higher-order structure elucidation of proteins by hydrogen/deuterium exchange followed by mass spectrometry (HDX-MS)
- Epitope mapping of antibodies by HDX-MS
- Higher-order structure elucidation of proteins by cross linking mass spectrometry (CX-MS)
- Development of the HDX-MS method
- Upstream and downstream processing of therapeutic proteins.
Keywords
- Former Faculty of Pharmaceutical Sciences
- HDX-MS
- Biopharmaceuticals
- Protein-Protein Interactions
- LC-MS
- LC-MS/MS
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A post-translational modification of human Norovirus capsid protein attenuates glycan binding
Mallagaray, A., Creutznacher, R., Dülfer, J., Mayer, P. H. O., Grimm, L. L., Orduña, J. M., Trabjerg, E., Stehle, T., Rand, K. D., Blaum, B. S., Uetrecht, C. & Peters, T., 1 Dec 2019, In: Nature Communications. 10, 1, 14 p., 1320.Research output: Contribution to journal › Journal article › Research › peer-review
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Investigating the Conformational Response of the Sortilin Receptor upon Binding Endogenous Peptide- and Protein Ligands by HDX-MS
Trabjerg, E., Abu-Asad, N., Wan, Z., Kartberg, F., Christensen, S. & Rand, K. D., 2 Jul 2019, In: Structure. 27, 7, p. 1103-1113.e3Research output: Contribution to journal › Journal article › Research › peer-review
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The First Community-Wide, Comparative Cross-linking Mass Spectrometry Study
Iacobucci, C., Piotrowski, C., Aebersold, R., Amaral, B. C., Andrews, P. C., Bernfur, K., Borchers, C. H., Brodie, N. I., Bruce, J. E., Cao, Y., Chaignepain, S., Chavez, J. D., Claverol, S., Cox, J., Davis, T. N., Degliesposti, G., Dong, M.-Q., Edinger, N., Emanuelsson, C. & Gay, M. & 53 others, , 4 Jun 2019, In: Analytical Chemistry. 91, 11, p. 6953-6961Research output: Contribution to journal › Journal article › Research › peer-review
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Conformational analysis of complex protein states by hydrogen/deuterium exchange mass spectrometry (HDX-MS): Challenges and emerging solutions
Trabjerg, E., Nazari, Z. E. & Rand, K. D., Sept 2018, In: Trends in Analytical Chemistry. 106, p. 125-138Research output: Contribution to journal › Review › peer-review
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Conformational characterization of nerve growth factor-β reveals that its regulatory pro-part domain stabilizes three loop regions in its mature part
Trabjerg, E., Kartberg, F., Christensen, S. & Rand, K. D., 6 Oct 2017, In: Journal of Biological Chemistry. 292, 40, p. 16665-16676 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Conformational analysis of large and highly disulfide-stabilized proteins by integrating online electrochemical reduction into an optimized H/D exchange mass spectrometry workflow
Trabjerg, E., Jakobsen, R. U., Mysling, S., Christensen, S., Jørgensen, T. J. D. & Rand, K. D., 1 Sept 2015, In: Analytical Chemistry. 87, 17, p. 8880–8888 9 p.Research output: Contribution to journal › Journal article › Research › peer-review