Publikationer pr. år
Publikationer pr. år
Personlig profil
Kort præsentation
H. Lundbeck A/S is developing treatments targeting neurodegenerative diseases. Several of the drugs in Lundbecks pipeline are monoclonal antibodies (mAbs). My task is to identify the epitope of several of these mAbs by employing the highly sensitive analytical method hydrogen/deuterium exchange followed by mass spectrometry.
Furthermore, in the Protein Analysis Group, Department of Pharmacy, University of Copenhagen my work focuses on development and improvement of mass spectrometric methods for probing the primary and higher-order structure of proteins and protein-complexes, especially HDX-MS.
Group webpage:
www.pharmacy.ku.dk/research/section_analytical_biosciences/protein_analysis-lab/
Primære forskningsområder
- Analysis of the primary and higher-order structure of proteins by LC-MS/MS
- Identification of protein-protein interaction sites
- Higher-order structure elucidation of proteins by hydrogen/deuterium exchange followed by mass spectrometry (HDX-MS)
- Epitope mapping of antibodies by HDX-MS
- Higher-order structure elucidation of proteins by cross linking mass spectrometry (CX-MS)
- Development of the HDX-MS method
- Upstream and downstream processing of therapeutic proteins.
Emneord
- Det tidligere Farmaceutiske Fakultet
- HDX-MS
- Biopharmaceuticals
- Protein-Protein Interactions
- LC-MS
- LC-MS/MS
Fingeraftryk
Dyk ned i forskningsemnerne, hvor Esben Trabjerg er aktive. Disse emneetiketter kommer fra dennes persons arbejder. Sammen danner de et unikt fingerprint.
- 1 Lignende profiler
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A post-translational modification of human Norovirus capsid protein attenuates glycan binding
Mallagaray, A., Creutznacher, R., Dülfer, J., Mayer, P. H. O., Grimm, L. L., Orduña, J. M., Trabjerg, E., Stehle, T., Rand, K. D., Blaum, B. S., Uetrecht, C. & Peters, T., 1 dec. 2019, I: Nature Communications. 10, 1, 14 s., 1320.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Investigating the Conformational Response of the Sortilin Receptor upon Binding Endogenous Peptide- and Protein Ligands by HDX-MS
Trabjerg, E., Abu-Asad, N., Wan, Z., Kartberg, F., Christensen, S. & Rand, K. D., 2 jul. 2019, I: Structure. 27, 7, s. 1103-1113.e3Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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The First Community-Wide, Comparative Cross-linking Mass Spectrometry Study
Iacobucci, C., Piotrowski, C., Aebersold, R., Amaral, B. C., Andrews, P. C., Bernfur, K., Borchers, C. H., Brodie, N. I., Bruce, J. E., Cao, Y., Chaignepain, S., Chavez, J. D., Claverol, S., Cox, J., Davis, T. N., Degliesposti, G., Dong, M-Q., Edinger, N., Emanuelsson, C., Gay, M., & 53 flere, 4 jun. 2019, I: Analytical Chemistry. 91, 11, s. 6953-6961Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Conformational analysis of complex protein states by hydrogen/deuterium exchange mass spectrometry (HDX-MS): Challenges and emerging solutions
Trabjerg, E., Nazari, Z. E. & Rand, K. D., sep. 2018, I: Trends in Analytical Chemistry. 106, s. 125-138Publikation: Bidrag til tidsskrift › Review › peer review
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Conformational characterization of nerve growth factor-β reveals that its regulatory pro-part domain stabilizes three loop regions in its mature part
Trabjerg, E., Kartberg, F., Christensen, S. & Rand, K. D., 6 okt. 2017, I: Journal of Biological Chemistry. 292, 40, s. 16665-16676 12 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Conformational analysis of large and highly disulfide-stabilized proteins by integrating online electrochemical reduction into an optimized H/D exchange mass spectrometry workflow
Trabjerg, E., Jakobsen, R. U., Mysling, S., Christensen, S., Jørgensen, T. J. D. & Rand, K. D., 1 sep. 2015, I: Analytical Chemistry. 87, 17, s. 8880–8888 9 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review