David Westergaard

Research output

Research output per year 2015 2018 2019 2019

• 11 Journal article
• 1 Conference abstract in journal
• 1 Conference article
• 1 Letter
• 1 More
  • 1 Review

Research output per year

Research output per year

Search results

• 2019

  Comorbidity landscape of the Danish patient population affected by chromosome abnormalities

  Jørgensen, I. F., Russo, F., Jensen, A. B., Westergaard, D., Lademann, M., Hu, J. X., Brunak, S. & Belling, K., 1 Nov 2019, In: Genetics In Medicine. 21, 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Chromosome Aberrations 100%
  • Comorbidity 80%
  • Fragile X Syndrome 66%
  • Down Syndrome 53%
  • Population 40%
  4 Citations (Scopus)

  2 Downloads (Pure)

• DBDS Genomic Cohort, a prospective and comprehensive resource for integrative and temporal analysis of genetic, environmental and lifestyle factors affecting health of blood donors

  Hansen, T. F., Banasik, K., Erikstrup, C., Pedersen, O. B., Westergaard, D., Chmura, P. J., Nielsen, K., Thørner, L., Hjalgrim, H., Paarup, H., Larsen, M. A. H., Petersen, M., Jennum, P., Andersen, S., Nyegaard, M., Jemec, G. B. E., Olesen, J., Werge, T., Johansson, P. I., Sørensen, E., & 3 othersBrunak, S., Ullum, H. & Burgdorf, K. S., 1 Jun 2019, In: BMJ Open. 9, 6, p. 1-7 7 p., e028401.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • 4,4'-dibenzamido-2,2'-stilbenedisulfonic acid 100%
  • Blood Donors 43%
  • Life Style 34%
  • Health 20%
  • Blood Banks 10%
  10 Citations (Scopus)

  12 Downloads (Pure)

• Herpes Simplex Virus Type 1 infection is associated with suicidal behavior and first registered psychiatric diagnosis in a healthy population

  Nissen, J., Trabjerg, B., Pedersen, M. G., Banasik, K., Pedersen, O. B., Sørensen, E., Nielsen, K. R., Erikstrup, C., Petersen, M. S., Paarup, H. M., Bruun-Rasmussen, P., Westergaard, D., Hansen, T. F., Pedersen, C. B., Werge, T., Torrey, F., Hjalgrim, H., Mortensen, P. B., Yolken, R., Brunak, S., & 2 othersUllum, H. & Burgdorf, K. S., Oct 2019, In: Psychoneuroendocrinology. 108, p. 150-154

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Human Herpesvirus 1 100%
  • Mental Disorders 73%
  • Infections 43%
  • C-Reactive Protein 40%
  • Population 35%
  3 Citations (Scopus)

  13 Downloads (Pure)

• Identification of hyper-rewired genomic stress non-oncogene addiction genes across 15 cancer types

  Hjaltelin, J. X., Izarzugaza, J. M. G., Jensen, L. J., Russo, F., Westergaard, D. & Brunak, S., 1 Dec 2019, In: npj Systems Biology and Applications. 5, 10 p., 27.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Genomics 100%
  • Drug Target 97%
  • Cancer 87%
  • Gene 83%
  • Genes 81%
  5 Citations (Scopus)

  7 Downloads (Pure)

• Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders

  Burgdorf, K. S., Trabjerg, B., Giørtz Pedersen, M., Nissen, J., Banasik, K., Birger Pedersen, O., Sørensen, E., René Nielsen, K., Hørup Larsen, M., Erikstrup, C., Bruun-Rasmussen, P., Westergaard, D., Wegner Thørner, L., Hjalgrim, H., Martina Paarup, H., Brunak, S., Pedersen, C. B., Fuller Torrey, E., Werge, T., Bo Mortensen, P., & 2 othersYolken, R. & Ullum, H., Jul 2019, In: Brain, Behavior, and Immunity. 79, p. 152-158

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Toxoplasma 100%
  • Cytomegalovirus 88%
  • Mental Disorders 72%
  • Confidence Intervals 53%
  • insulin receptor-related receptor 44%
  44 Citations (Scopus)

  195 Downloads (Pure)

• Population-wide analysis of differences in disease progression patterns in men and women

  Westergaard, D., Moseley, P., Sørup, F. K. H., Baldi, P. & Brunak, S., 1 Dec 2019, In: Nature Communications. 10, 1, 14 p., 666.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • progressions 100%
  • Disease Progression 71%
  • medicine 47%
  • occurrences 35%
  • Population 34%
  34 Citations (Scopus)

  35 Downloads (Pure)
• 2018

  A comprehensive and quantitative comparison of text-mining in 15 million full-text articles versus their corresponding abstracts

  Westergaard, D., Stærfeldt, H-H., Tønsberg, C., Jensen, L. J. & Brunak, S., 2018, In: PLoS Computational Biology. 14, 2, 16 p., e1005962.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Text Mining 100%
  • Data Mining 72%
  • Text mining 69%
  • Text 55%
  • Protein 46%
  53 Citations (Scopus)

  81 Downloads (Pure)

• Comorbidity landscape of the Danish patient population affected by chromosomal abnormalities

  Russo, F., Jørgensen, I. F., Westergaard, D., Jensen, A. B., Hu, J. X., Belling, K. & Brunak, S., 2018, In: European Journal of Human Genetics. 26, p. 697-698

  Research output: Contribution to journal › Conference abstract in journal › Research

  14 Citations (Scopus)

• Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducers

  Tsafou, K., Katschnig, A. M., Radic-Sarikas, B., Mutz, C. N., Iljin, K., Schwentner, R., Kauer, M. O., Mühlbacher, K., Aryee, D. N. T., Westergaard, D., Haapa-Paananen, S., Fey, V., Superti-Furga, G., Toretsky, J., Brunak, S. & Kovar, H., 24 Jul 2018, In: OncoTarget. 9, 57, p. 31018-31031 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • EWS-FLI fusion protein 100%
  • Ewing's Sarcoma 74%
  • Apoptosis 37%
  • Oncogene Fusion 16%
  • Bone Neoplasms 12%
  3 Citations (Scopus)

  62 Downloads (Pure)

• Unexplored therapeutic opportunities in the human genome

  Oprea, T. I., Bologa, C. G., Brunak, S., Campbell, A., Gan, G. N., Gaulton, A., Gomez, S. M., Guha, R., Hersey, A., Holmes, J., Jadhav, A., Jensen, L. J., Johnson, G. L., Karlson, A., Leach, A. R., Ma'ayan, A., Malovannaya, A., Mani, S., Mathias, S. L., McManus, M. T., & 21 othersMeehan, T. F., von Mering, C., Muthas, D., Nguyen, D-T., Overington, J. P., Papadatos, G., Qin, J., Reich, C., Roth, B. L., Schürer, S. C., Simeonov, A., Sklar, L. A., Southall, N., Tomita, S., Tudose, I., Ursu, O., Vidovic, D., Waller, A., Westergaard, D., Yang, J. J. & Zahoránszky-Köhalmi, G., 2018, In: Nature Reviews. Drug Discovery. 17, 5, p. 317-332 16 p.

  Research output: Contribution to journal › Review › peer-review

  • Human Genome 100%
  • Biomedical Research 47%
  • Protein 39%
  • G-Protein-Coupled Receptor Kinases 36%
  • Proteins 35%
  108 Citations (Scopus)
• 2017

  Klinefelter syndrome comorbidities linked to increased X chromosome gene dosage and altered protein interactome activity

  Belling, K., Russo, F., Jensen, A. B., Dalgaard, M. D., Westergaard, D., Rajpert-De Meyts, E., Skakkebæk, N. E., Juul, A. & Brunak, S., 1 Apr 2017, In: Human Molecular Genetics. 26, 7, p. 1219-1229 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Klinefelter Syndrome 100%
  • X-Linked Genes 92%
  • Gene Dosage 85%
  • Comorbidity 56%
  • Systems Biology 28%
  35 Citations (Scopus)

  75 Downloads (Pure)

• Sequencing and de novo assembly of 150 genomes from Denmark as a population reference

  Sørensen, L. M., Jensen, J. M., Petersen, B., Sibbesen, J. A., Liu, S., Villesen, P., Skov, L., Belling, K. G., Have, C. T., Izarzugaza, J. M. G., Grosjean, M., Bork-Jensen, J., Grove, J., Als, T. D., Huang, S., Chang, Y., Xu, R., Ye, W., Rao, J., Guo, X., & 39 othersSun, J., Cao, H., Ye, C., van Beusekom, J., Espeseth, T., Flindt, E., Friborg, R. M., Halager, A. E., Le Hellard, S., Hultman, C. M., Lescai, F., Li, S., Lund, O., Løngren, P., Mailund, T., Matey-Hernandez, M. L., Mors, O., Pedersen, C. N. S., Sicheritz-Pontén, T., Sullivan, P., Syed, A., Westergaard, D., Yadav, R., Li, N., Xu, X., Hansen, T., Krogh, A., Bolund, L., Sørensen, T. I. A., Pedersen, O. B., Gupta, R., Rasmussen, S., Besenbacher, S., Børglum, A. D., Wang, J., Eiberg, H. R. L., Kristiansen, K., Brunak, S. & Schierup, M. H., 3 Aug 2017, In: Nature. 548, 7665, p. 87-91 5 p.

  Research output: Contribution to journal › Letter › peer-review

  • Denmark 100%
  • Genome 63%
  • Genetic Variation 60%
  • Catalogs 39%
  • Y Chromosome 38%
  52 Citations (Scopus)

  291 Downloads (Pure)
• 2016

  TEMPORAL ORDER OF DISEASE PAIRS AFFECTS SUBSEQUENT DISEASE TRAJECTORIES: THE CASE OF DIABETES AND SLEEP APNEA

  Beck, M. K., Westergaard, D., Jensen, A. B., Groop, L. & Brunak, S., 2016, In: Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. 22, p. 380-389 10 p.

  Research output: Contribution to journal › Conference article › Research › peer-review

  • Sleep Apnea Syndromes 100%
  • Multimorbidity 10%
  • Denmark 8%
  • Electronic Health Records 7%
  • Respiration 6%
  8 Citations (Scopus)
• 2015

  Acquisition of docetaxel resistance in breast cancer cells reveals upregulation of ABCB1 expression as a key mediator of resistance accompanied by discrete upregulation of other specific genes and pathways

  Hansen, S. N., Westergaard, D., Thomsen, M. B. H., Vistesen, M. V., Do, K. N., Fogh, L., Belling, K. G., Wang, J., Yang, H., Gupta, R., Ditzel, H. J., Moreira, J., Brünner, N., Stenvang, J. & Rasmussen, A-S. S., 11 Jun 2015, In: Tumor Biology. 36, 6, p. 4327-4338 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Docetaxel 100%
  • Up-Regulation 64%
  • Breast Neoplasms 57%
  • Glycoproteins 45%
  • Permeability 38%
  25 Citations (Scopus)

• Novel variation and de novo mutation rates in population-wide de novo assembled Danish trios

  Besenbacher, S., Liu, S., Gonzalez-Izarzugaza, J. M., Grove, J., Belling, K. G., Bork-Jensen, J., Huang, S., Als, T. D., Li, S., Yadav, R., Rubio García, A., Lescai, F., Demontis, D., Rao, J., Ye, W., Mailund, T., Møllegaard Friborg, R., Pedersen, C. N. S., Xu, R., Sun, J., & 27 othersLiu, H., Wang, O., Cheng, X., Flores, D., Rydza, E. K., Rapacki, K., Sørensen, J. D., Chmura, P. J., Westergaard, D., Dworzynski, P., Sørensen, T. I. A., Lund, O., Hansen, T., Xu, X., Li, N., Bolund, L., Pedersen, O., Eiberg, H., Krogh, A., Børglum, A. D., Brunak, S., Kristiansen, K., Schierup, M. H., Wang, J., Gupta, R., Villesen, P. & Rasmussen, S., Jan 2015, In: Nature Communications. 6, 9 p., 5969.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • nucleotides 100%
  • mutations 92%
  • Mutation Rate 84%
  • Mutation 67%
  • Nucleotide 65%
  90 Citations (Scopus)

  122 Downloads (Pure)