Anne Tybjærg-Hansen

2019

Blood–brain barrier transcytosis genes, risk of dementia and stroke: a prospective cohort study of 74,754 individuals

Juul Rasmussen, I., Tybjærg-Hansen, A., Rasmussen, K. L., Nordestgaard, B. G. & Frikke-Schmidt, R., 2019, In: European Journal of Epidemiology. 34, 6, p. 579-590 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

20 Downloads (Pure)

Causal Associations in Type 2 Diabetes Development

Marott, S. C. W., Nordestgaard, B. G., Tybjærg-Hansen, A. & Benn, M., 1 Apr 2019, In: The Journal of clinical endocrinology and metabolism. 104, 4, p. 1313-1324

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

Equalization of four cardiovascular risk algorithms after systematic recalibration: individual-participant meta-analysis of 86 prospective studies

Pennells, L., Kaptoge, S., Wood, A., Sweeting, M., Zhao, X., White, I., Burgess, S., Willeit, P., Bolton, T., Moons, K. G. M., van der Schouw, Y. T., Selmer, R., Khaw, K-T., Gudnason, V., Assmann, G., Amouyel, P., Salomaa, V., Kivimaki, M., Nordestgaard, B. G., Blaha, M. J., & 255 othersKuller, L. H., Brenner, H., Gillum, R. F., Meisinger, C., Ford, I., Knuiman, M. W., Rosengren, A., Lawlor, D. A., Volzke, H., Cooper, C., Ibanez, A. M., Casiglia, E., Kauhanen, J., Cooper, J. A., Rodriguez, B., Sundstrom, J., Barrett-Connor, E., Dankner, R., Nietert, P. J., Davidson, K. W., Wallace, R. B., Blazer, D. G., Bjorkelund, C., Donfrancesco, C., Krumholz, H. M., Nissinen, A., Davis, B. R., Coady, S., Whincup, P. H., Jørgensen, T., Ducimetiere, P., Trevisan, M., Engstrom, G., Crespo, C. J., Meade, T., Visser, M., Kromhout, D., Kiechl, S., Daimon, M., Price, J. F., de la Camara, A. G., Jukema, J. W., Lamarche, B., Onat, A., Simons, L. A., Kavousi, M., Ben-Shlomo, Y., Gallacher, J., Dekker, J. M., Arima, H., Shara, N., Tipping, R., Roussel, R., Brunner, E. J., Koenig, W., Sakurai, M., Pavlovic, J., Gansevoort, R. T., Nagel, D., Goldbourt, U., Barr, E. L. M., Palmieri, L., Njølstad, I., Sato, S., Verschuren, W. M. M., Varghese, C. V., Graham, I., Onuma, O., Greenland, P., Woodward, M., Ezzati, M., Psaty, B. M., Sattar, N., Jackson, R., Ridker, P. M., Cook, N., D'Agostino, R. B. . S., Thompson, S. G., Danesh, J., Di Angelantonio, E., Tipping, R. W., Simpson, L. M., Pressel, S. L., Couper, D. J., Nambi, V., Matsushita, K., Folsom, A. R., Shaw, J. E., Magliano, D. J., Zimmet, P. Z., Knuiman, M. W., Whincup, P. H., Wannamethee, S. G., Willeit, J., Santer, P., Egger, G., Casas, J. P., Amuzu, A., Ben-Shlomo, Y., Gallacher, J., Tikhonoff, V., Casiglia, E., Sutherland, S. E., Nietert, P. J., Cushman, M., Psaty, B. M., Sogaard, A. J., Haheim, L. L., Ariansen, I., Tybjærg-Hansen, A., Jensen, G. B., Schnohr, P., Giampaoli, S., Vanuzzo, D., Panico, S., Palmieri, L., Balkau, B., Bonnet, F., Marre, M., de la Camara, A. G., Herrera, M. A. R., Friedlander, Y., McCallum, J., McLachlan, S., Guralnik, J., Phillips, C. L., Guralnik, J., Khaw, K-T., Wareham, N., Schottker, B., Saum, K-U., Holleczek, B., Nissinen, A., Tolonen, H., Giampaoli, S., Donfrancesco, C., Jousilahti, P., Harald, K., D'Agostino, R. B. . S., Massaro, J. M., Pencina, M., Vasan, R., Massaro, J. M., Pencina, M., Vasan, R., Kayama, T., Kato, T., Oizumi, T., Jespersen, J., Møller, L., Bladbjerg, E. M., Chetrit, A., Rosengren, A., Wilhelmsen, L., Bjorkelund, C., Lissner, L., Nagel, D., Dennison, E., Kiyohara, Y., Ninomiya, T., Doi, Y., Rodriguez, B., Nijpels, G., Stehouwer, C. D. A., Sato, S., Kazumasa, Y., Iso, H., Goldbourt, U., Salomaa, V., Vartiainen, E., Kurl, S., Tuomainen, T-P., Salonen, J. T., Visser, M., Deeg, D. J. H., Meade, T., Nilsson, P. M., Hedblad, B., Melander, O., De Boer, I. H., DeFilippis, A. P., Verschuren, W. M. M., Sattar, N., Watt, G., Meisinger, C., Koenig, W., Verschuren, M., Rosengren, A., Kuller, L. H., Tverdal, A., Gillum, R. F., Cooper, J. A., Kirkland, S., Shimbo, D., Shaffer, J., Sato, S., Kazumasa, Y., Iso, H., Ducimetiere, P., Bakker, S. J. L., van der Harst, P., Hillege, H. L., Crespo, C. J., Amouyel, P., Dallongeville, J., Assmann, G., Schulte, H., Trompet, S., Smit, R. A. J., Stott, D. J., van der Schouw, Y. T., Despres, J-P., Cantin, B., Dagenais, G. R., Laughlin, G., Wingard, D., Khaw, K-T., Trevisan, M., Aspelund, T., Eiriksdottir, G., Gudmundsson, E. F., Ikram, A., van Rooij, F. J. A., Franco, O. H., Rueda-Ochoa, O. L., Muka, T., Glisic, M., Tunstall-Pedoe, H., Volzke, H., Howard, B. V., Zhang, Y., Jolly, S., Gallacher, J., Davey-Smith, G., Can, G., Yuksel, H., Nakagawa, H., Morikawa, Y., Miura, K., Njølstad, I., Ingelsson, M., Giedraitis, V., Ridker, P. M., Gaziano, J. M., Kivimaki, M., Shipley, M., Brunner, E. J., Arndt, V., Brenner, H., Cook, N., Ridker, P. M., Ford, I., Sattar, N., Ibanez, A. M. & Geleijnse, J. M., 14 Feb 2019, In: European Heart Journal. 40, 7, p. 621-631 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

32 Citations (Scopus)

53 Downloads (Pure)

2018

ABCA7 and risk of dementia and vascular disease in the Danish population

Kjeldsen, E. W., Tybjærg-Hansen, A., Nordestgaard, B. G. & Frikke-Schmidt, R., 2018, In: Annals of Clinical and Translational Neurology. 5, 1, p. 41-51 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

104 Downloads (Pure)

Advances in lipid-lowering therapy through gene-silencing technologies

Nordestgaard, B. G., Nicholls, S. J., Langsted, A., Ray, K. K. & Tybjærg-Hansen, A., 1 May 2018, In: Nature Reviews Cardiology. 15, p. 261-272

Research output: Contribution to journal › Review › peer-review

47 Citations (Scopus)

APOC3 Loss-of-Function Mutations, Remnant Cholesterol, Low-Density Lipoprotein Cholesterol, and Cardiovascular Risk: Mediation- and Meta-Analyses of 137 895 Individuals

Wulff, A. B., Nordestgaard, B. G. & Tybjærg-Hansen, A., 2018, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 38, 3, p. 660-668

Research output: Contribution to journal › Journal article › Research › peer-review

30 Citations (Scopus)

Association of LPA Variants With Risk of Coronary Disease and the Implications for Lipoprotein(a)-Lowering Therapies: A Mendelian Randomization Analysis

European Prospective Investigation Into Cancer and Nutrition–Cardiovascular Disease (EPIC-CVD) Consortium, Jul 2018, In: JAMA Cardiology. 3, 7, p. 619-627 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

150 Citations (Scopus)

Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes

Gusarova, V., O'Dushlaine, C., Teslovich, T. M., Benotti, P. N., Mirshahi, T., Gottesman, O., Van Hout, C. V., Murray, M. F., Mahajan, A., Nielsen, J. B., Fritsche, L., Wulff, A. B., Gudbjartsson, D. F., Sjögren, M., Emdin, C. A., Scott, R. A., Lee, W. J., Small, A., Kwee, L. C., Dwivedi, O. P., & 61 othersPrasad, R. B., Bruse, S., Lopez, A. E., Penn, J., Marcketta, A., Leader, J. B., Still, C. D., Kirchner, H. L., Mirshahi, U. L., Wardeh, A. H., Hartle, C. M., Habegger, L., Fetterolf, S. N., Tusie-Luna, T., Morris, A. P., Holm, H., Steinthorsdottir, V., Sulem, P., Thorsteinsdottir, U., Rotter, J. I., Chuang, L. M., Damrauer, S., Birtwell, D., Brummett, C. M., Khera, A. V., Natarajan, P., Orho-Melander, M., Flannick, J., Lotta, L. A., Willer, C. J., Holmen, O. L., Ritchie, M. D., Ledbetter, D. H., Murphy, A. J., Borecki, I. B., Reid, J. G., Overton, J. D., Hansson, O., Groop, L., Shah, S. H., Kraus, W. E., Rader, D. J., Chen, Y. D. I., Hveem, K., Wareham, N. J., Kathiresan, S., Melander, O., Stefansson, K., Nordestgaard, B. G., Tybjærg-Hansen, A., Abecasis, G. R., Altshuler, D., Florez, J. C., Boehnke, M., McCarthy, M. I., Yancopoulos, G. D., Carey, D. J., Shuldiner, A. R., Baras, A., Dewey, F. E. & Gromada, J., 2018, In: Nature Communications. 9, 1, 2252.

Research output: Contribution to journal › Journal article › Research › peer-review

49 Citations (Scopus)

29 Downloads (Pure)

Genetic variants in CYP7A1 and risk of myocardial infarction and symptomatic gallstone disease

Qayyum, F., Lauridsen, B. K., Frikke-Schmidt, R., Kofoed, K. F., Nordestgaard, B. G. & Tybjærg-Hansen, A., 2018, In: European Heart Journal. 39, 22, p. 2106-2116 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

14 Citations (Scopus)

Genetic variation in clusterin and risk of dementia and ischemic vascular disease in the general population: Cohort studies and meta-analyses of 362,338 individuals

Nordestgaard, L. T., Tybjærg-Hansen, A., Rasmussen, K. L., Nordestgaard, B. G. & Frikke-Schmidt, R., 2018, In: BMC Medicine. 16, 11 p., 39.

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

Liver fat content, non-alcoholic fatty liver disease, and ischaemic heart disease: Mendelian randomization and meta-analysis of 279 013 individuals

Lauridsen, B. K., Stender, S., Kristensen, T. S., Kofoed, K. F., Køber, L., Nordestgaard, B. G. & Tybjærg-Hansen, A., 2018, In: European Heart Journal. 39, 5, p. 385-393 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

62 Citations (Scopus)

Naturally Occurring Variants in LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) Affect HDL (High-Density Lipoprotein) Metabolism Through ABCA1 (ATP-Binding Cassette A1) and SR-B1 (Scavenger Receptor Class B Type 1) in Humans

Oldoni, F., van Capelleveen, J. C., Dalila, N., Wolters, J. C., Heeren, J., Sinke, R. J., Hui, D. Y., Dallinga-Thie, G. M., Frikke-Schmidt, R., Hovingh, K. G., van de Sluis, B., Tybjærg-Hansen, A. & Kuivenhoven, J. A., 1 Jul 2018, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 38, 7, p. 1440-1453 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Overview of the current status of familial hypercholesterolaemia care in over 60 countries - The EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)

Vallejo-Vaz, A. J., Marco, M. D., Stevens, C. A. T., Akram, A., Freiberger, T., Hovingh, G. K., Kastelein, J. J. P., Mata, P., Raal, F. J., Santos, R. D., Soran, H., Watts, G. F., Abifadel, M., Aguilar Salinas, C. A., Al-Khnifsawi, M., Alkindi, F. A., Alnouri, F., Alonso, R., Al-Rasadi, K., Al-Sarraf, A., & 248 othersAshavaid, T. F., Binder, C. J., Bogsrud, M. P., Bourbon, M., Bruckert, E., Chlebus, K., Corral, P., Descamps, O., Durst, R., Ezhov, M., Fras, Z., Genest, J., Groselj, U., Harada-Shiba, M., Kayikçioglu, M., Lalic, K., Lam, C. S. P., Latkovskis, G., Laufs, U., Liberopoulos, E., Lin, J., Maher, V., Majano, N., Marais, D., März, W., Mirrakhimov, E., Miserez, A. R., Mitchenko, O., Nawawi, H. M., Nordestgaard, B. G., Paragh, G., Petrulioniene, Z., Pojskic, B., Postadzhiyan, A., Reda, A., Reiner, Ž., Sadoh, W. E., Sahebkar, A., Shehab, A., Shek, A. B., Stoll, M., Su, T. C., Subramaniam, T., Susekov, A. V., Symeonides, P., Tilney, M., Tomlinson, B., Truong, T. H., Tselepis, A. D., Tybjærg-Hansen, A., Vázquez-Cárdenas, A., Viigimaa, M., Vohnout, B., Widén, E., Yamashita, S., Banach, M., Gaita, D., Jiang, L., Nilsson, L., Santos, L. E., Schunkert, H., Tokgözoğlu, L., Car, J., Catapano, A. L., Ray, K. K., Schreier, L., Pang, J., Dieplinger, H., Hanauer-Mader, G., Desutter, J., Langlois, M., Mertens, A., Rietzschel, E., Wallemacq, C., Isakovic, D., Dzankovic, A. M., Obralija, J., Pojskic, L., Sisic, I., Stimjanin, E., Torlak, V. A., Jannes, C. E., Krieger, J. E., Pereira, A. C., Ruel, I., Asenjo, S., Cuevas, A., Pećin, I., Miltiadous, G., Panayiotou, A. G., Vrablik, M., Benn, M., Heinsar, S., Béliard, S., Gouni-Berthold, I., Hengstenberg, W., Julius, U., Kassner, U., Klose, G., König, C., König, W., Otte, B., Parhofer, K., Schatz, U., Schmidt, N., Steinhagen-Thiessen, E., Vogt, A., Antza, C., Athyros, V., Bilianou, E., Boufidou, A., Chrousos, G., Elisaf, M., Garoufi, A., Katsiki, N., Kolovou, G., Kotsis, V., Rallidis, L., Rizos, C., Skalidis, E., Skoumas, I., Tziomalos, K., Shawney, J. P. S., Abbaszadegan, M. R., Aminzadeh, M., Hosseini, S., Mobini, M., Vakili, R., Zaeri, H., Agar, R., Boran, G., Colwell, N., Crowley, V., Durkin, M., Griffin, D., Kelly, M., Rakovac-Tisdall, A., Bitzur, R., Cohen, H., Eliav, O., Ellis, A., Gavish, D., Harats, D., Henkin, Y., Knobler, H., Leavit, L., Leitersdorf, E., Schurr, D., Shpitzen, S., Szalat, A., Arca, M., Averna, M., Bertolini, S., Calandra, S., Tarugi, P., Erglis, A., Gilis, D., Nesterovics, G., Saripo, V., Upena-Roze, A., Elbitar, S., Jambart, S., Khoury, P. E., Gargalskaite, U., Kutkiene, S., Al-Khateeb, A., An, C. Y., Ismail, Z., Kasim, S., Ibrahim, K. S., Radzi, A. B. M., Kasim, N. A., Nor, N. S. M., Ramli, A. S., Razak, S. A., Muid, S., Rosman, A., Sanusi, A. R., Razman, A. Z., Nazli, S. A., Kek, T. L., Azzopardi, C., Aguilar Salinas, C. A., Galán, G., Rubinstein, A., Magaña-Torres, M. T., Martagon, A., Mehta, R., Wittekoek, M. E., Isara, A. R., Obaseki, D. E., Ohenhen, O. A., Holven, K. B., Gruchała, M., Baranowska, M., Borowiec-Wolny, J., Gilis-Malinowska, N., Michalska-Grzonkowska, A., Pajkowski, M., Parczewska, A., Romanowska-Kocejko, M., Stróżyk, A., Żarczyńska-Buchowiecka, M., Kleinschmidt, M., Alves, A. C., Medeiros, A. M., Ershova, A., Korneva, V., Kuznetsova, T., Malyshev, P., Meshkov, A., Rozhkova, T., Popovic, L., Lukac, S. S., Stosic, L., Rasulic, I., Lalic, N. M., Chua, T. S. J., Ting, S. P. L., Raslova, K., Battelino, T., Cevc, M., Jug, B., Kovac, J., Podkrajsek, K. T., Sustar, U., Trontelj, K. J., Marais, D., Isla, L. P. D., Martin, F. J., Charng, M. J., Chen, P. L., Kayikçioglu, M., Dell’oca, N., Fernández, G., Ressia, A., Reyes, X., Zelarayan, M., Alieva, R. B., Hoshimov, S. U., Nizamov, U. I., Kurbanov, R. D., Lima-Martínez, M. M., Nguyen, M. N. T., Do, D. L., Kim, N. T., Le, T. T. & Le, H. A., 2018, In: Atherosclerosis. 277, p. 234-255 22 p.

Research output: Contribution to journal › Journal article › Research › peer-review

68 Citations (Scopus)

Plasma apolipoprotein E levels and risk of dementia: A Mendelian randomization study of 106,562 individuals

Rasmussen, K. L., Tybjærg-Hansen, A., Nordestgaard, B. G. & Frikke-Schmidt, R., Jan 2018, In: Alzheimer's & Dementia. 14, 1, p. 71-80

Research output: Contribution to journal › Journal article › Research › peer-review

27 Citations (Scopus)

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Turcot, V., Lu, Y., Highland, H. M., Bang, L. E., Benn, M., Kamstrup, P. R., Bork-Jensen, J., Frikke-Schmidt, R., Gjesing, A. P., Grarup, N., Hansen, T., Have, C. T., Jørgensen, T., Nielsen, S. F., Linneberg, A. R., Pedersen, O., Pers, T. H., Vestergaard, H., Nordestgaard, B., Tybjærg-Hansen, A., & 15 othersVarbo, A., CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetics Consortium, GoT2D Genes Consortium, EPIC-InterAct Consortium, INTERVAL Study, ReproGen Consortium, T2D-Genes Consortium, The MAGIC Investigators, Understanding Society Scientific Group, Lindgren, C. M., Hirschhorn, J. N. & Loos, R. J. F., 1 Jan 2018, In: Nature Genetics. 50, p. 26-41 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

128 Citations (Scopus)

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

Mahajan, A., Wessel, J., Willems, S. M., Zhao, W., Robertson, N. R., Chu, A. Y., Gan, W., Kitajima, H., Taliun, D., Rayner, N. W., Guo, X., Lu, Y., Li, M., Jensen, R. A., Hu, Y., Huo, S., Lohman, K. K., Zhang, W., Cook, J. P., Prins, B. P., & 31 othersFlannick, J., Grarup, N., Trubetskoy, V. V., Kravic, J., Kim, Y. J., Rybin, D. V., Yaghootkar, H., Müller-Nurasyid, M., Meidtner, K., Li-Gao, R., Varga, T. V., Marten, J., Li, J., Afzal, S., Bork-Jensen, J., Tybjærg-Hansen, A., Jørgensen, M. E., Jørgensen, T., Kovacs, P., Linneberg, A., Liu, J., Nielsen, S. F., Rode, L., Witte, D. R., Hansen, T., Karpe, F., Lind, L., Loos, R. J. F., Nordestgaard, B. G., Pedersen, O. & ExomeBP Consortium, 1 Apr 2018, In: Nature Genetics. 50, 4, p. 559-571 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

130 Citations (Scopus)

Relationship between genetic variation at PPP1R3B and levels of liver glycogen and triglyceride

Stender, S., Smagris, E., Lauridsen, B. K., Kofoed, K. F., Nordestgaard, B. G., Tybjærg-Hansen, A., Pennacchio, L. A., Dickel, D. E., Cohen, J. C. & Hobbs, H. H., 2018, In: Hepatology. 67, 6, p. 2182-2195 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

24 Citations (Scopus)

Response to: liver fat content, non-alcoholic fatty liver disease, and ischaemic heart disease

Stender, S. & Tybjaerg-Hansen, A., 21 Sept 2018, In: European Heart Journal. 39, 36, p. 3399

Research output: Contribution to journal › Comment/debate › Research › peer-review

U-shaped relationship of HDL and risk of infectious disease: two prospective population-based cohort studies

Madsen, C. M., Varbo, A., Tybjærg-Hansen, A., Frikke-Schmidt, R. & Nordestgaard, B. G., 7 Apr 2018, In: European Heart Journal. 39, 14, p. 1181-1190 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

58 Citations (Scopus)

2017

Adiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci

Stender, S., Kozlitina, J., Nordestgaard, B. G., Tybjærg-Hansen, A., Hobbs, H. H. & Cohen, J. C., Jun 2017, In: Nature Genetics. 49, 6, p. 842-847 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

131 Citations (Scopus)

Blood Chimerism in Dizygotic Monochorionic Twins During 5 Years Observation

Dziegiel, M. H., Hansen, M. H., Haedersdal, S., Barrett, A. N., Rieneck, K., Main, K. M., Hansen, A. T. & Clausen, F. B., Oct 2017, In: American Journal of Transplantation. 17, 10, p. 2728-2732

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

Body mass index and risk of Alzheimer's disease: A mendelian randomization study of 399,536 individuals

Nordestgaard, L. T., Tybjærg-Hansen, A., Nordestgaard, B. G. & Frikke-Schmidt, R., Jul 2017, In: Journal of Clinical Endocrinology and Metabolism. 102, 7, p. 2310-2320 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

Effect of APOE ε Genotype on Lipoprotein(a) and the Associated Risk of Myocardial Infarction and Aortic Valve Stenosis

Kritharides, L., Nordestgaard, B. G., Tybjærg-Hansen, A., Kamstrup, P. R. & Afzal, S., 1 Sept 2017, In: The Journal of clinical endocrinology and metabolism. 102, 9, p. 3390-3399 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

Exome-wide association study of plasma lipids in >300,000 individuals

Liu, D. J., Peloso, G. M., Yu, H., Butterworth, A. S., Wang, X., Mahajan, A., Saleheen, D., Emdin, C., Alam, D., Alves, A. C., Amouyel, P., Angelantonio, E. DI., Arveiler, D., Assimes, T. L., Auer, P. L., Baber, U., Ballantyne, C. M., Bang, L. E., Benn, M., Bis, J. C., & 207 othersBoehnke, M., Boerwinkle, E., Bork-Jensen, J., Bottinger, E. P., Brandslund, I., Brown, M., Busonero, F., Caulfield, M. J., Chambers, J. C., Chasman, D. I., Chen, Y. E., Chen, Y. D. I., Chowdhury, R., Christensen, C., Chu, A. Y., Connell, J. M., Cucca, F., Cupples, L. A., Damrauer, S. M., Davies, G., Deary, I. J., Dedoussis, G., Denny, J. C., Dominiczak, A., Dubé, M. P., Ebeling, T., Eiriksdottir, G., Esko, T., Farmaki, A. E., Feitosa, M. F., Ferrario, M., Ferrieres, J., Ford, I., Fornage, M., Franks, P. W., Frayling, T. M., Frikke-Schmidt, R., Fritsche, L. G., Frossard, P., Fuster, V., Ganesh, S. K., Gao, W., Garcia, M. E., Gieger, C., Giulianini, F., Goodarzi, M. O., Grallert, H., Grarup, N., Groop, L., Grove, M. L., Gudnason, V., Hansen, T., Harris, T. B., Hayward, C., Hirschhorn, J. N., Holmen, O. L., Huffman, J., Huo, Y., Hveem, K., Jabeen, S., Jackson, A. U., Jakobsdottir, J., Jarvelin, M. R., Jensen, G. B., Jørgensen, M. E., Jukema, J. W., Justesen, J. M., Kamstrup, P. R., Kanoni, S., Karpe, F., Kee, F., Khera, A. V., Klarin, D., Koistinen, H. A., Kooner, J. S., Kooperberg, C., Kuulasmaa, K., Kuusisto, J., Laakso, M., Lakka, T., Langenberg, C., Langsted, A., Launer, L. J., Lauritzen, T., MLiewald, D. C., Lin, L. A., Linneberg, A., Loos, R. J. F., Lu, Y., Lu, X., Mägi, R., Malarstig, A., Manichaikul, A., Manning, A. K., Mäntyselkä, P., Marouli, E., Masca, N. G. D., Maschio, A., Meigs, J. B., Melander, O., Metspalu, A., Morris, A. P., Morrison, A. C., Mulas, A., Müller-Nurasyid, M., Munroe, P. B., Neville, M. J., Nielsen, S. F., Nielsen, J. B., Nordestgaard, B. G., Ordovas, J. M., Mehran, R., O'Donnell, C. J., Orho-Melander, M., Molony, C. M., Muntendam, P., Padmanabhan, S., Palmer, C. N. A., Pasko, D., Patel, A. P., Pedersen, O., Perola, M., Peters, A., Pisinger, C., Pistis, G., Polasek, O., Poulter, N., Psaty, B. M., Rader, D. J., Rasheed, A., Rauramaa, R., Reilly, D. F., Reiner, A. P., Renström, F., Rich, S. S., Ridker, P. M., Rioux, J. D., Robertson, N. R., Roden, D. M., Rotter, J. I., Rudan, I., Salomaa, V., Samani, N. J., Sanna, S., Sattar, N., Schmidt, E. M., Scott, R. A., Sever, P., Sevilla, R. S., Shaffer, C. M., Sim, X., Sivapalaratnam, S., Small, K. S., Smith, A. V., Smith, B. H., Somayajula, S., Southam, L., Spector, T. D., Speliotes, E. K., Starr, J. M., Stirrups, K. E., Stitziel, N., Strauch, K., Stringham, H. M., Surendran, P., Tada, H., Tall, A. R., Tang, H., Tardif, J. C., Taylor, K. D., Trompet, S., Tsao, P. S., Tuomilehto, J., Tybjaerg-Hansen, A., Zuydam, N. R. V., Varbo, A., Varga, T. V., Virtamo, J., Waldenberger, M., Wang, N., Wareham, N. J., Warren, H. R., Weeke, P. E., Weinstock, J., Wessel, J., Wilson, J. G., Wilson, P. W. F., Xu, M., Yaghootkar, H., Young, R., Zeggini, E., Zhang, H., Zheng, N. S., Zhang, W., Zhang, Y., Zhou, W., Zhou, Y., Zoledziewska, M., Howson, J. M. M., Danesh, J., McCarthy, M. I., Cowan, C. A., Abecasis, G., Deloukas, P., Musunuru, K., Willer, C. J. & Kathiresan, S., 1 Dec 2017, In: Nature Genetics. 49, 12, p. 1758-1766 9 p.

Research output: Contribution to journal › Letter › peer-review

209 Citations (Scopus)

50 Downloads (Pure)

Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms

Howson, J. M. M., Zhao, W., Barnes, D. R., Ho, W. K., Young, R., Paul, D. S., Waite, L., Freitag, D. F., Fauman, E. B., Salfati, E. L., Sun, B. B., Eicher, J. D., Johnson, A. D., Sheu, W. H-H., Nielsen, S. F., Lin, W-Y., Surendran, P., Malarstig, A., Wilk, J. B., Tybjærg-Hansen, A., & 36 othersRasmussen, K. L., Kamstrup, P. R., Deloukas, P., Erdmann, J., Kathiresan, S., Samani, N. J., Schunkert, H., Watkins, H., CARDIoGRAMplusC4D, Do, R., Rader, D. J., Johnson, J. A., Hazen, S. L., Quyyumi, A. A., Spertus, J. A., Pepine, C. J., Franceschini, N., Justice, A. E., Reiner, A. P., Buyske, S., Hindorff, L. A., Carty, C. L., North, K. E., Kooperberg, C., Boerwinkle, E., Young, K. L., Graff, M., Peters, U., Absher, D., Hsiung, C. A., EPIC-CVD Consortium, Nordestgaard, B. G., Assimes, T. L., Danesh, J., Butterworth, A. S. & Saleheen, D., 1 Jul 2017, In: Nature Genetics. 49, p. 1113-1119

Research output: Contribution to journal › Letter › peer-review

136 Citations (Scopus)

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease

Dewey, F. E., Gusarova, V., Dunbar, R. L., O'Dushlaine, C. T., Schurmann, C., Gottesman, O., McCarthy, S., Van Hout, C. V., Bruse, S., Dansky, H. M., Leader, J. B., Murray, M. F., Ritchie, M. D., Kirchner, H. L., Habegger, L., Lopez, A., Penn, J., Zhao, A., Shao, W., Stahl, N., & 37 othersMurphy, A. J., Hamon, S., Bouzelmat, A., Zhang, R., Shumel, B., Pordy, R., Gipe, D., Herman, G. A., Sheu, W. H-H., Lee, I-T., Liang, K-W., Guo, X., Rotter, J. I., Chen, Y. I., Kraus, W. E., Shah, S. H., Damrauer, S., Small, A., Rader, D. J., Wulff, A. B., Nordestgaard, B. G., Tybjærg-Hansen, A., van den Hoek, A. M., Princen, H. M. G., Ledbetter, D. H., Carey, D. J., Overton, J. D., Reid, J. G., Sasiela, W. J., Banerjee, P., Shuldiner, A. R., Borecki, I. B., Teslovich, T. M., Yancopoulos, G. D., Mellis, S. J., Gromada, J. & Baras, A., 20 Jul 2017, In: New England Journal of Medicine. 377, 3, p. 211-221

Research output: Contribution to journal › Journal article › Research › peer-review

286 Citations (Scopus)

Genetic Variation in GSTP1, Lung Function, Risk of Lung Cancer, and Mortality

Nørskov, M. S., Dahl, M. & Tybjærg-Hansen, A., Nov 2017, In: Journal of Thoracic Oncology. 12, 11, p. 1664-1672 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

Genetic variation in WRN and ischemic stroke: General population studies and meta-analyses

Christoffersen, M., Frikke-Schmidt, R., Nordestgaard, B. G. & Tybjærg-Hansen, A., Mar 2017, In: Experimental Gerontology. 89, p. 69-77 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease

Zhao, W., Rasheed, A., Tikkanen, E., Lee, J-J., Butterworth, A. S., Howson, J. M. M., Assimes, T. L., Chowdhury, R., Orho-Melander, M., Damrauer, S., Small, A., Asma, S., Imamura, M., Yamauch, T., Chambers, J. C., Chen, P., Sapkota, B. R., Shah, N., Jabeen, S., Surendran, P., & 31 othersLu, Y., Zhang, W., Imran, A., Abbas, S., Majeed, F., Trindade, K., Qamar, N., Mallick, N. H., Yaqoob, Z., Saghir, T., Rizvi, S. N. H., Memon, A., Rasheed, S. Z., Memon, F-U-R., Mehmood, K., Ahmed, N., Qureshi, I. H., Tanveer-Us-Salam, Iqbal, W., Malik, U., Mehra, N., Kuo, J. Z., Sheu, W. H-H., Guo, X., Hsiung, C. A., Juang, J-M. J., Nordestgaard, B. G., Tybjaerg-Hansen, A., Benn, M., Frikke-Schmidt, R. & CHD Exome+ Consortium, 1 Oct 2017, In: Nature Genetics. 49, 10, p. 1450-1457 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

91 Citations (Scopus)

Low LDL cholesterol, PCSK9 and HMGCR genetic variation, and risk of Alzheimer's disease and Parkinson's disease: Mendelian randomisation study

Benn, M., Nordestgaard, B. G., Frikke-Schmidt, R. & Tybjærg-Hansen, A., 24 Apr 2017, In: B M J. 357, 11 p., j1648.

Research output: Contribution to journal › Journal article › Research › peer-review

67 Citations (Scopus)

68 Downloads (Pure)

Rare and low-frequency coding variants alter human adult height

Marouli, E., Graff, M., Medina-Gomez, C., Lo, K. S., Wood, A. R., Kjaer, T. R., Fine, R. S., Lu, Y., Schurmann, C., Highland, H. M., Rüeger, S., Thorleifsson, G., Justice, A. E., Lamparter, D., Stirrups, K. E., Turcot, V., Young, K. L., Winkler, T. W., Esko, T., Karaderi, T., & 31 othersLocke, A. E., Masca, N. G. D., Ng, M. C. Y., Mudgal, P., Rivas, M. A., Vedantam, S., Mahajan, A., Guo, X., Abecasis, G., Aben, K. K., Allin, K. H., Appel, E. V., Bang, L. E., Benn, M., Bork-Jensen, J., Frikke-Schmidt, R., Grarup, N., Hansen, T., Hollensted, M., Jensen, G. B., Jørgensen, M. E., Jørgensen, T., Kamstrup, P. R., Linneberg, A., Nielsen, S. F., Nordestgaard, B. G., Pedersen, O., Tybjaerg-Hansen, A., Vestergaard, H., Pers, T. H. & EPIC-InterAct Consortium, 9 Feb 2017, In: Nature. 542, 7640, p. 186-190 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

277 Citations (Scopus)

Using genetics to explore whether the cholesterol-lowering drug ezetimibe may cause an increased risk of cancer

Kobberø Lauridsen, B., Stender, S., Frikke-Schmidt, R., Nordestgaard, B. G. & Tybjærg-Hansen, A., 1 Dec 2017, In: International Journal of Epidemiology. 46, 6, p. 1777-1785

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits

Tachmazidou, I., Süveges, D., Min, J. L., Ritchie, G. R. S., Steinberg, J., Walter, K., Iotchkova, V., Schwartzentruber, J., Huang, J., Memari, Y., McCarthy, S., Crawford, A. J., Bombieri, C., Cocca, M., Farmaki, A-E., Gaunt, T. R., Jousilahti, P., Kooijman, M. N., Lehne, B., Malerba, G., & 31 othersMännistö, S., Matchan, A., Medina-Gomez, C., Metrustry, S. J., Nag, A., Ntalla, I., Paternoster, L., Rayner, N. W., Sala, C., Scott, W. R., Shihab, H. A., Southam, L., St Pourcain, B., Traglia, M., Trajanoska, K., Zaza, G., Zhang, W., Artigas, M. S., Bansal, N., Benn, M., Chen, Z., Danecek, P., Lin, W-Y., Locke, A. E., Luan, J., Manning, A. K., Mulas, A., Sidore, C., Tybjaerg-Hansen, A., Nordestgaard, B. G. & SpiroMeta Consortium, 1 Jun 2017, In: American Journal of Human Genetics. 100, 6, p. 865-884 20 p.

Research output: Contribution to journal › Journal article › Research › peer-review

47 Citations (Scopus)

60 Downloads (Pure)

2016

Change in Body Mass Index Associated With Lowest Mortality in Denmark, 1976-2013

Afzal, S., Tybjærg-Hansen, A., Jensen, G. B. & Nordestgaard, B. G., 10 May 2016, In: J A M A: The Journal of the American Medical Association. 315, 18, p. 1989-96 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

86 Citations (Scopus)

Components of the Metabolic Syndrome and Risk of Type 2 Diabetes

Marott, S. C. W., Nordestgaard, B. G., Tybjærg-Hansen, A. & Benn, M., Aug 2016, In: The Journal of clinical endocrinology and metabolism. 101, 8, p. 3212-3221 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

27 Citations (Scopus)

Data on plasma levels of apolipoprotein E, correlations with lipids and lipoproteins stratified by APOE genotype, and risk of ischemic heart disease

Rasmussen, K. L., Tybjærg-Hansen, A., Nordestgaard, B. G. & Frikke-Schmidt, R., 1 Mar 2016, In: Data in Brief. 6, p. 923-932 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

89 Downloads (Pure)

Four Susceptibility Loci for Gallstone Disease Identified in a Meta-analysis of Genome-Wide Association Studies

Joshi, A. D., Andersson, C., Buch, S., Stender, S., Noordam, R., Weng, L-C., Weeke, P. E., Auer, P. L., Boehm, B., Chen, C., Choi, H., Curhan, G., Denny, J. C., De Vivo, I., Eicher, J. D., Ellinghaus, D., Folsom, A. R., Fuchs, C., Gala, M., Haessler, J., & 35 othersHofman, A., Hu, F., Hunter, D. J., Janssen, H. L. A., Kang, J. H., Kooperberg, C., Kraft, P., Kratzer, W., Lieb, W., Lutsey, P. L., Darwish Murad, S., Nordestgaard, B. G., Pasquale, L. R., Reiner, A. P., Ridker, P. M., Rimm, E., Rose, L. M., Shaffer, C. M., Schafmayer, C., Tamimi, R. M., Uitterlinden, A. G., Völker, U., Völzke, H., Wakabayashi, Y., Wiggs, J. L., Zhu, J., Roden, D. M., Stricker, B. H. C., Tang, W., Teumer, A., Hampe, J., Tybjærg-Hansen, A., Chasman, D. I., Chan, A. T. & Johnson, A. D., 1 Aug 2016, In: Gastroenterology. 151, 2, 351 p.

Research output: Contribution to journal › Journal article › Research › peer-review

40 Citations (Scopus)

Genetics of Coronary Artery Disease

McPherson, R. & Tybjærg-Hansen, A., 19 Feb 2016, In: Circulation Research. 118, 4, p. 564-578 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

149 Citations (Scopus)

High body mass index and cancer risk

Benn, M., Tybjærg-Hansen, A., Smith, G. D. & Nordestgaard, B. G., Sept 2016, In: European Journal of Epidemiology. 31, 9, p. 879-92 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

22 Citations (Scopus)

High lipoprotein(a) as a possible cause of clinical familial hypercholesterolaemia: a prospective cohort study

Langsted, A., Kamstrup, P. R., Benn, M., Tybjærg-Hansen, A. & Nordestgaard, B. G., 1 Jul 2016, In: The Lancet Diabetes and Endocrinology. 4, 7, p. 577-587 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

117 Citations (Scopus)

Increased Baseline C-Reactive Protein Concentrations Are Associated with Increased Risk of Infections: Results from 2 Large Danish Population Cohorts

Zacho, J., Benfield, T., Tybjærg-Hansen, A. & Nordestgaard, B. G., Feb 2016, In: Clinical Chemistry. 62, 2, p. 335-42 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

Lipoprotein(a) and familial hypercholesterolaemia - Authors' reply

Langsted, A., Kamstrup, P. R., Benn, M., Tybjærg-Hansen, A. & Nordestgaard, B. G., 1 Sept 2016, In: The Lancet Diabetes and Endocrinology. 4, 9, p. 730-731 2 p.

Research output: Contribution to journal › Comment/debate › Research › peer-review

Mutations causative of familial hypercholesterolaemia: screening of 98 098 individuals from the Copenhagen General Population Study estimated a prevalence of 1 in 217

Benn, M., Watts, G. F., Tybjærg-Hansen, A. & Nordestgaard, B. G., 1 May 2016, In: European Heart Journal. 37, 17, p. 1384-94 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

219 Citations (Scopus)

PCSK9 R46L Loss-of-Function Mutation Reduces Lipoprotein(a), LDL Cholesterol, and Risk of Aortic Valve Stenosis

Langsted, A., Nordestgaard, B., Benn, M., Tybjærg-Hansen, A. & Kamstrup, P. R., Sept 2016, In: The Journal of clinical endocrinology and metabolism. 101, 9, p. 3281-3287 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

42 Citations (Scopus)

Plakophilin-2 c.419C>T and risk of heart failure and arrhythmias in the general population

Christensen, A. H., Kamstrup, P. R., Gandjbakhch, E., Benn, M., Jensen, J. S., Bundgaard, H., Villard, E. & Tybjærg-Hansen, A., 1 May 2016, In: European Journal of Human Genetics. 24, 5, p. 732-8 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

Plasma levels of apolipoprotein E and risk of ischemic heart disease in the general population

Rasmussen, K. L., Tybjærg-Hansen, A., Nordestgaard, B. G. & Frikke-Schmidt, R., 1 Mar 2016, In: Atherosclerosis. 246, p. 63-70 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

16 Citations (Scopus)

Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease

CHD Exome+ Consortium, CARDIoGRAM Exome Consortium & Global Lipids Genetics Consortium, 11 Mar 2016, In: Science (New York, N.Y.). 351, 6278, p. 1166-71 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

278 Citations (Scopus)

Response to the Letter: Response to "Use of biomarkers to identify new drug targets and to predict risk of cardiometabolic outcomes" by Abasi A., et al

Holmegard, H. N., Nordestgaard, B., Jensen, G. B., Tybjærg-Hansen, A. & Benn, M., Feb 2016, In: The Journal of clinical endocrinology and metabolism. 101, 2, p. L22-L23

Research output: Contribution to journal › Letter › peer-review

SCARB1 Gene Variants Are Associated With the Phenotype of Combined High High-Density Lipoprotein Cholesterol and High Lipoprotein (a)

Yang, X., Sethi, A. A., Yanek, L. R., Knapper, C., Nordestgaard, B., Tybjærg-Hansen, A., Becker, D. M., Mathias, R. A., Remaley, A. T. & Becker, L. C., 1 Oct 2016, In: Circulation: Cardiovascular Genetics. 9, 5, p. 408-418 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

Sex Hormones and Ischemic Stroke: A Prospective Cohort Study and Meta-Analyses

Holmegard, H. N., Nordestgaard, B. G., Jensen, G. B., Tybjærg-Hansen, A. & Benn, M., Jan 2016, In: The Journal of Clinical Endocrinology & Metabolism. 101, 1, p. 69-78 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

35 Citations (Scopus)

Anne Tybjærg-Hansen

Research output

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