Anne-Marie Heegaard

Research output

Research output per year 1991 2000 2004 2008 2012 2015 2017 2018 2019 2019

• 58 Journal article
• 4 Poster
• 2 Review
• 1 Conference abstract for conference
• 1 More
  • 1 Conference abstract in journal

Research output per year

Research output per year

Search results

• 2004

  Measurement of tumor load and distribution in a model of cancer-induced osteolysis: a necessary precaution when testing novel anti-resorptive therapies

  Amhlaoibh, R. N., Hoegh-Andersen, P., Brünner, N., Sørensen, A., Winding, B., Holst-Hansen, C., Karsdal, M. A., Engsig, M. T., Delaissé, J-M. & Heegaard, A-M., 2004, In: Clinical and Experimental Metastasis. 21, 1, p. 65-74 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Osteolysis 100%
  • Tumor Burden 78%
  • Radiography 45%
  • beta-Galactosidase 38%
  • Ibandronic Acid 36%
  3 Citations (Scopus)

• Ovariectomized rats as a model of postmenopausal osteoarthritis: validation and application

  Høegh-Andersen, P., Tankó, L. B., Andersen, T. L., Lundberg, C. V., Mo, J. A., Heegaard, A-M., Delaissé, J-M. & Christgau, S., 2004, In: Arthritis Research & Therapy. 6, 2, p. R169-80

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Osteoarthritis 100%
  • Cartilage 98%
  • Ovariectomy 55%
  • Estrogens 51%
  • Selective Estrogen Receptor Modulators 33%
  189 Citations (Scopus)

• The chloride channel inhibitor NS3736 [corrected] prevents bone resorption in ovariectomized rats without changing bone formation

  Schaller, S., Henriksen, K. S., Sveigaard, C., Heegaard, A-M., Hélix, N., Stahlhut, M., Ovejero, M. C., Johansen, J. V., Solberg, H., Andersen, T. L., Hougaard, D., Berryman, M., Shiødt, C. B., Sørensen, T. B., Lichtenberg, J., Christophersen, P., Foged, N., Delaissé, J-M., Engsig, M. T. & Karsdal, M. A., 2004, In: Journal of Bone and Mineral Research. 19, 7, p. 1144-53 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Chloride Channels 100%
  • Bone Resorption 80%
  • Osteogenesis 69%
  • Osteoclasts 20%
  • Bone Remodeling 20%
  128 Citations (Scopus)

• Transforming growth factor beta stimulation of biglycan gene expression is potentially mediated by sp1 binding factors

  Heegaard, A-M., Xie, Z., Young, M. F. & Nielsen, K. L., 2004, In: Journal of Cellular Biochemistry. 93, 3, p. 463-75 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Biglycan 100%
  • Transforming Growth Factor beta 60%
  • Gene Expression 39%
  • Transforming Growth Factor beta3 14%
  • Transforming Growth Factor beta2 14%
  21 Citations (Scopus)
• 2003

  Biglycan deficiency interferes with ovariectomy-induced bone loss

  Nielsen, K. L., Allen, M. R., Bloomfield, S. A., Andersen, T. L., Chen, X-D., Poulsen, H. S., Young, M. F. & Heegaard, A-M., 2003, In: Journal of Bone and Mineral Research. 18, 12, p. 2152-8 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Biglycan 100%
  • Ovariectomy 74%
  • Bone and Bones 39%
  • Proteoglycans 18%
  • Cancellous Bone 17%
  43 Citations (Scopus)
• 2002

  Synthetic matrix metalloproteinase inhibitors inhibit growth of established breast cancer osteolytic lesions and prolong survival in mice

  Winding, B., NicAmhlaoibh, R., Misander, H., Høegh-Andersen, P., Andersen, T. L., Holst-Hansen, C., Heegaard, A-M., Foged, N. T., Brünner, N. & Delaissé, J-M., 2002, In: Clinical Cancer Research. 8, 6, p. 1932-9 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • HSCH2CH(CH2CH(CH3)2)CO-Phe-Ala-NH2 100%
  • Matrix Metalloproteinase Inhibitors 68%
  • Breast Neoplasms 36%
  • Neoplasm Metastasis 35%
  • Growth 28%
  56 Citations (Scopus)
• 2000

  Lack of influence of collagen type Ialpha1 Sp1 binding site polymorphism on the rate of bone loss in a cohort of postmenopausal danish women followed for 18 years

  Heegaard, A-M., Jorgensen, H. L., Vestergaard, A. W., Hassager, C. & Ralston, S. H., 2000, In: Calcified Tissue International. 66, 6, p. 409-13 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Binding Sites 100%
  • Collagen 98%
  • Genotype 93%
  • Bone and Bones 77%
  • Metabolic Bone Diseases 56%
  50 Citations (Scopus)

• No major effect of estrogen receptor gene polymorphisms on bone mineral density or bone loss in postmenopausal Danish women

  Bagger, Y. Z., Jørgensen, H. L., Heegaard, A-M., Bayer, L., Hansen, L. & Hassager, C., 2000, In: Bone. 26, 2, p. 111-6 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Estrogen Receptors 100%
  • Bone Density 96%
  • Bone and Bones 63%
  • Genotype 54%
  • Forearm 44%
  69 Citations (Scopus)

• Proteinases in bone resorption: obvious and less obvious roles

  Delaissé, J-M., Engsig, M. T., Everts, V., del Carmen Ovejero, M., Ferreras, M., Lund, L., Vu, T. H., Werb, Z., Winding, B., Lochter, A., Karsdal, M. A., Troen, T., Kirkegaard, T., Lenhard, T., Heegaard, A-M., Neff, L., Baron, R. & Foged, N., 2000, In: Clinica Chimica Acta. 291, 2, p. 223-34 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Interstitial 100%
  • Bone Resorption 97%
  • Solubilization 92%
  • Peptide Hydrolases 80%
  • Cathepsin K 27%
  162 Citations (Scopus)

• Vitamin D receptor and estrogen receptor gene polymorphisms in postmenopausal Danish women: no relation to bone markers or serum lipoproteins

  Bagger, Y. Z., Hassager, C., Heegaard, A-M. & Christiansen, C., 2000, In: Climacteric. 3, 2, p. 84-91 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Calcitriol Receptors 100%
  • Lipoproteins 78%
  • Estrogen Receptors 77%
  • glutamyl-lysyl-alanyl-histidyl-aspartyl-glycyl-glycyl-arginine 68%
  • Biomarkers 54%
  13 Citations (Scopus)
• 1998

  Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice

  Xu, T., Bianco, P., Fisher, L. W., Longenecker, G., Smith, E., Goldstein, S., Bonadio, J., Boskey, A., Heegaard, A-M., Sommer, B., Satomura, K., Dominguez, P., Zhao, C., Kulkarni, A. B., Robey, P. G. & Young, M. F., 1998, In: Nature Genetics. 20, 1, p. 78-82 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Biglycan 100%
  • Osteoporosis 59%
  • Phenotype 40%
  • Bone and Bones 39%
  • Extracellular Matrix Proteins 37%
  482 Citations (Scopus)
• 1997

  Functional characterization of the human biglycan 5'-flanking DNA and binding of the transcription factor c-Krox

  Heegaard, A-M., Gehron Robey, P., Vogel, W., Just, W., Widom, R. L., Schøller, J., Fisher, L. W. & Young, M. F., 1997, In: Journal of Bone and Mineral Research. 12, 12, p. 2050-60 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Biglycan 100%
  • Transcription Factors 50%
  • DNA 37%
  • Sex Chromosomes 21%
  • Turner Syndrome 21%
  26 Citations (Scopus)

• Identification of the membrane-type matrix metalloproteinase MT1-MMP in osteoclasts

  Sato, T., del Carmen Ovejero, M., Hou, P. C. A., Heegaard, A-M., Kumegawa, M., Foged, N. & Delaissé, J-M., 1997, In: Journal of Cell Science. 110 ( Pt 5), p. 589-96 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Matrix Metalloproteinase 14 100%
  • Osteoclasts 74%
  • Matrix Metalloproteinases 69%
  • Membranes 43%
  • Mouse Mmp14 protein 21%
  191 Citations (Scopus)
• 1993

  Structure and molecular regulation of bone matrix proteins

  Robey, P. G., Fedarko, N. S., Hefferan, T. E., Bianco, P., Vetter, U. K., Grzesik, W., Friedenstein, A., van der Pluijm, G., Mintz, K. P., Young, M. F., Kerr, J. M., Ibaraki, K. & Heegaard, AM. M., 1 Jan 1993, In: Journal of Bone and Mineral Research. 8, 2 S, p. S483-S487

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Bone Matrix 100%
  • Molecular Structure 99%
  • Proteins 30%
  • Glycoproteins 28%
  • Intrinsic Factor 20%
  102 Citations (Scopus)
• 1992

  Structure, expression, and regulation of the major noncollagenous matrix proteins of bone

  Young, M. F., Kerr, J. M., Ibaraki, K., Heegaard, A-M. & Robey, P. G., 1992, In: Clinical Orthopaedics and Related Research. 281, p. 275-94 20 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Bone Matrix 100%
  • Proteins 30%
  • Osteocalcin 24%
  • Bone and Bones 22%
  • Amino Acid Sequence 13%
  195 Citations (Scopus)
• 1991

  Human biglycan gene. Putative promoter, intron-exon junctions, and chromosomal localization

  Fisher, L. W., Heegaard, A-M., Vetter, U., Vogel, W., Just, W., Termine, J. D. & Young, M. F., 1991, In: Journal of Biological Chemistry. 266, 22, p. 14371-7 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Biglycan 100%
  • Proteoglycan 83%
  • Introns 64%
  • Exons 55%
  • Core Protein 43%
  119 Citations (Scopus)