Proteinases in bone resorption: obvious and less obvious roles

Jean-Marie Delaissé; M T Engsig; V Everts; M del Carmen Ovejero; M Ferreras; L Lund; T H Vu; Z Werb; B Winding; A Lochter; M A Karsdal; Tine Troen; T Kirkegaard; T Lenhard; Anne-Marie Heegaard; L Neff; R Baron; Niels Foged

Proteinases in bone resorption: obvious and less obvious roles

Jean-Marie Delaissé, M T Engsig, V Everts, M del Carmen Ovejero, M Ferreras, L Lund, T H Vu, Z Werb, B Winding, A Lochter, M A Karsdal, Tine Troen, T Kirkegaard, T Lenhard, Anne-Marie Heegaard, L Neff, R Baron, Niels Foged

162 Citations (Scopus)

Abstract

Bone resorption is critical for the development and the maintenance of the skeleton, and improper regulation of bone resorption leads to pathological situations. Proteinases are necessary for this process. In this review, we show that this need of proteinases is not only because they are required for the solubilization of bone matrix, but also because they are key components of the mechanism that determines where and when bone resorption will be initiated. Moreover, there are indications that proteinases may also determine whether resorption will be followed by bone formation. Some of the proteinases involved in these different steps of the resorption processes were recently identified, as for instance cathepsin K, MMP-9 (gelatinase B), and interstitial collagenase. However, there is also increasing evidence showing that the critical proteinase(s) may vary depending on the bone type or on other factors.

Original language	English
Journal	Clinica Chimica Acta
Volume	291
Issue number	2
Pages (from-to)	223-34
Number of pages	12
ISSN	0009-8981
Publication status	Published - 2000
Externally published	Yes

Keywords

Bone Diseases
Bone Resorption
Endopeptidases
Extracellular Matrix
Humans

Cite this

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title = "Proteinases in bone resorption: obvious and less obvious roles",

abstract = "Bone resorption is critical for the development and the maintenance of the skeleton, and improper regulation of bone resorption leads to pathological situations. Proteinases are necessary for this process. In this review, we show that this need of proteinases is not only because they are required for the solubilization of bone matrix, but also because they are key components of the mechanism that determines where and when bone resorption will be initiated. Moreover, there are indications that proteinases may also determine whether resorption will be followed by bone formation. Some of the proteinases involved in these different steps of the resorption processes were recently identified, as for instance cathepsin K, MMP-9 (gelatinase B), and interstitial collagenase. However, there is also increasing evidence showing that the critical proteinase(s) may vary depending on the bone type or on other factors.",

keywords = "Bone Diseases, Bone Resorption, Endopeptidases, Extracellular Matrix, Humans",

author = "Jean-Marie Delaiss{\'e} and Engsig, {M T} and V Everts and {del Carmen Ovejero}, M and M Ferreras and L Lund and Vu, {T H} and Z Werb and B Winding and A Lochter and Karsdal, {M A} and Tine Troen and T Kirkegaard and T Lenhard and Anne-Marie Heegaard and L Neff and R Baron and Niels Foged",

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language = "English",

volume = "291",

pages = "223--34",

journal = "Clinica Chimica Acta",

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TY - JOUR

T1 - Proteinases in bone resorption

T2 - obvious and less obvious roles

AU - Delaissé, Jean-Marie

AU - Engsig, M T

AU - Everts, V

AU - del Carmen Ovejero, M

AU - Ferreras, M

AU - Lund, L

AU - Vu, T H

AU - Werb, Z

AU - Winding, B

AU - Lochter, A

AU - Karsdal, M A

AU - Troen, Tine

AU - Kirkegaard, T

AU - Lenhard, T

AU - Heegaard, Anne-Marie

AU - Neff, L

AU - Baron, R

AU - Foged, Niels

PY - 2000

Y1 - 2000

N2 - Bone resorption is critical for the development and the maintenance of the skeleton, and improper regulation of bone resorption leads to pathological situations. Proteinases are necessary for this process. In this review, we show that this need of proteinases is not only because they are required for the solubilization of bone matrix, but also because they are key components of the mechanism that determines where and when bone resorption will be initiated. Moreover, there are indications that proteinases may also determine whether resorption will be followed by bone formation. Some of the proteinases involved in these different steps of the resorption processes were recently identified, as for instance cathepsin K, MMP-9 (gelatinase B), and interstitial collagenase. However, there is also increasing evidence showing that the critical proteinase(s) may vary depending on the bone type or on other factors.

AB - Bone resorption is critical for the development and the maintenance of the skeleton, and improper regulation of bone resorption leads to pathological situations. Proteinases are necessary for this process. In this review, we show that this need of proteinases is not only because they are required for the solubilization of bone matrix, but also because they are key components of the mechanism that determines where and when bone resorption will be initiated. Moreover, there are indications that proteinases may also determine whether resorption will be followed by bone formation. Some of the proteinases involved in these different steps of the resorption processes were recently identified, as for instance cathepsin K, MMP-9 (gelatinase B), and interstitial collagenase. However, there is also increasing evidence showing that the critical proteinase(s) may vary depending on the bone type or on other factors.

KW - Bone Diseases

KW - Bone Resorption

KW - Endopeptidases

KW - Extracellular Matrix

KW - Humans

M3 - Journal article

C2 - 10675725

SN - 0009-8981

VL - 291

SP - 223

EP - 234

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

IS - 2

ER -

Proteinases in bone resorption: obvious and less obvious roles

Abstract

Keywords

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