Biglycan deficiency interferes with ovariectomy-induced bone loss

Karina L Nielsen; Matthew R Allen; Susan A Bloomfield; Thomas L Andersen; Xiao-Dong Chen; Hans S Poulsen; Marian F Young; Anne-Marie Heegaard

doi:10.1359/jbmr.2003.18.12.2152

Biglycan deficiency interferes with ovariectomy-induced bone loss

Karina L Nielsen, Matthew R Allen, Susan A Bloomfield, Thomas L Andersen, Xiao-Dong Chen, Hans S Poulsen, Marian F Young, Anne-Marie Heegaard

43 Citations (Scopus)

Abstract

Biglycan is a matrix proteoglycan with a possible role in bone turnover. In a 4-week study with sham-operated or OVX biglycan-deficient or wildtype mice, we show that biglycan-deficient mice are resistant to OVX-induced trabecular bone loss and that there is a gender difference in the response to biglycan deficiency.

Original language	English
Journal	Journal of Bone and Mineral Research
Volume	18
Issue number	12
Pages (from-to)	2152-8
Number of pages	7
ISSN	0884-0431
DOIs	https://doi.org/10.1359/jbmr.2003.18.12.2152
Publication status	Published - 2003

Keywords

Animals
Biglycan
Bone Density
Carrier Proteins
Extracellular Matrix Proteins
Female
Glycoproteins
Male
Membrane Glycoproteins
Mice
Mice, Inbred C57BL
Mice, Knockout
Models, Animal
Osteoclasts
Osteoporosis
Osteoprotegerin
Ovariectomy
Proteoglycans
RANK Ligand
Receptor Activator of Nuclear Factor-kappa B
Receptors, Cytoplasmic and Nuclear
Receptors, Tumor Necrosis Factor

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10.1359/jbmr.2003.18.12.2152

Cite this

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title = "Biglycan deficiency interferes with ovariectomy-induced bone loss",

abstract = "Biglycan is a matrix proteoglycan with a possible role in bone turnover. In a 4-week study with sham-operated or OVX biglycan-deficient or wildtype mice, we show that biglycan-deficient mice are resistant to OVX-induced trabecular bone loss and that there is a gender difference in the response to biglycan deficiency.",

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author = "Nielsen, {Karina L} and Allen, {Matthew R} and Bloomfield, {Susan A} and Andersen, {Thomas L} and Xiao-Dong Chen and Poulsen, {Hans S} and Young, {Marian F} and Anne-Marie Heegaard",

year = "2003",

doi = "10.1359/jbmr.2003.18.12.2152",

language = "English",

volume = "18",

pages = "2152--8",

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TY - JOUR

T1 - Biglycan deficiency interferes with ovariectomy-induced bone loss

AU - Nielsen, Karina L

AU - Allen, Matthew R

AU - Bloomfield, Susan A

AU - Andersen, Thomas L

AU - Chen, Xiao-Dong

AU - Poulsen, Hans S

AU - Young, Marian F

AU - Heegaard, Anne-Marie

PY - 2003

Y1 - 2003

N2 - Biglycan is a matrix proteoglycan with a possible role in bone turnover. In a 4-week study with sham-operated or OVX biglycan-deficient or wildtype mice, we show that biglycan-deficient mice are resistant to OVX-induced trabecular bone loss and that there is a gender difference in the response to biglycan deficiency.

AB - Biglycan is a matrix proteoglycan with a possible role in bone turnover. In a 4-week study with sham-operated or OVX biglycan-deficient or wildtype mice, we show that biglycan-deficient mice are resistant to OVX-induced trabecular bone loss and that there is a gender difference in the response to biglycan deficiency.

KW - Animals

KW - Biglycan

KW - Bone Density

KW - Carrier Proteins

KW - Extracellular Matrix Proteins

KW - Female

KW - Glycoproteins

KW - Male

KW - Membrane Glycoproteins

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - Models, Animal

KW - Osteoclasts

KW - Osteoporosis

KW - Osteoprotegerin

KW - Ovariectomy

KW - Proteoglycans

KW - RANK Ligand

KW - Receptor Activator of Nuclear Factor-kappa B

KW - Receptors, Cytoplasmic and Nuclear

KW - Receptors, Tumor Necrosis Factor

U2 - 10.1359/jbmr.2003.18.12.2152

DO - 10.1359/jbmr.2003.18.12.2152

M3 - Journal article

C2 - 14672350

SN - 0884-0431

VL - 18

SP - 2152

EP - 2158

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

IS - 12

ER -

Biglycan deficiency interferes with ovariectomy-induced bone loss

Abstract

Keywords

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