The chloride channel inhibitor NS3736 [corrected] prevents bone resorption in ovariectomized rats without changing bone formation

Sophie Schaller; Kim Steen Henriksen; Christina Sveigaard; Anne-Marie Heegaard; Nathalie Hélix; Martin Stahlhut; Maria C Ovejero; Jens V Johansen; Helene Solberg; Thomas L Andersen; Dorit Hougaard; Mark Berryman; Christine B Shiødt; Tobias Bjørn Sørensen; Jens Lichtenberg; Palle Christophersen; Niels Foged; Jean-Marie Delaissé; Michael T Engsig; Morten A Karsdal

doi:10.1359/JBMR.040302

The chloride channel inhibitor NS3736 [corrected] prevents bone resorption in ovariectomized rats without changing bone formation

Sophie Schaller, Kim Steen Henriksen, Christina Sveigaard, Anne-Marie Heegaard, Nathalie Hélix, Martin Stahlhut, Maria C Ovejero, Jens V Johansen, Helene Solberg, Thomas L Andersen, Dorit Hougaard, Mark Berryman, Christine B Shiødt, Tobias Bjørn Sørensen, Jens Lichtenberg, Palle Christophersen, Niels Foged, Jean-Marie Delaissé, Michael T Engsig, Morten A Karsdal

128 Citations (Scopus)

Abstract

Chloride channel activity is essential for osteoclast function. Consequently, inhibition of the osteoclastic chloride channel should prevent bone resorption. Accordingly, we tested a chloride channel inhibitor on bone turnover and found that it inhibits bone resorption without affecting bone formation. This study indicates that chloride channel inhibitors are highly promising for treatment of osteoporosis.

Original language	English
Journal	Journal of Bone and Mineral Research
Volume	19
Issue number	7
Pages (from-to)	1144-53
Number of pages	10
ISSN	0884-0431
DOIs	https://doi.org/10.1359/JBMR.040302
Publication status	Published - 2004
Externally published	Yes

Keywords

Animals
Bone Resorption
Cells, Cultured
Chloride Channels
Coated Pits, Cell-Membrane
Female
Gene Expression Profiling
Humans
Osteoclasts
Osteogenesis
Ovariectomy
Rats
Rats, Sprague-Dawley
Tetrazoles
Tissue Distribution

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10.1359/JBMR.040302

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Schaller, S., Henriksen, K. S., Sveigaard, C., Heegaard, A-M., Hélix, N., Stahlhut, M., Ovejero, M. C., Johansen, J. V., Solberg, H., Andersen, T. L., Hougaard, D., Berryman, M., Shiødt, C. B., Sørensen, T. B., Lichtenberg, J., Christophersen, P., Foged, N., Delaissé, J-M., Engsig, M. T., & Karsdal, M. A. (2004). The chloride channel inhibitor NS3736 [corrected] prevents bone resorption in ovariectomized rats without changing bone formation. Journal of Bone and Mineral Research, 19(7), 1144-53. https://doi.org/10.1359/JBMR.040302

Schaller, S, Henriksen, KS, Sveigaard, C, Heegaard, A-M, Hélix, N, Stahlhut, M, Ovejero, MC, Johansen, JV, Solberg, H, Andersen, TL, Hougaard, D, Berryman, M, Shiødt, CB, Sørensen, TB, Lichtenberg, J, Christophersen, P, Foged, N, Delaissé, J-M, Engsig, MT & Karsdal, MA 2004, 'The chloride channel inhibitor NS3736 [corrected] prevents bone resorption in ovariectomized rats without changing bone formation', Journal of Bone and Mineral Research, vol. 19, no. 7, pp. 1144-53. https://doi.org/10.1359/JBMR.040302

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title = "The chloride channel inhibitor NS3736 [corrected] prevents bone resorption in ovariectomized rats without changing bone formation",

abstract = "Chloride channel activity is essential for osteoclast function. Consequently, inhibition of the osteoclastic chloride channel should prevent bone resorption. Accordingly, we tested a chloride channel inhibitor on bone turnover and found that it inhibits bone resorption without affecting bone formation. This study indicates that chloride channel inhibitors are highly promising for treatment of osteoporosis.",

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author = "Sophie Schaller and Henriksen, {Kim Steen} and Christina Sveigaard and Anne-Marie Heegaard and Nathalie H{\'e}lix and Martin Stahlhut and Ovejero, {Maria C} and Johansen, {Jens V} and Helene Solberg and Andersen, {Thomas L} and Dorit Hougaard and Mark Berryman and Shi{\o}dt, {Christine B} and S{\o}rensen, {Tobias Bj{\o}rn} and Jens Lichtenberg and Palle Christophersen and Niels Foged and Jean-Marie Delaiss{\'e} and Engsig, {Michael T} and Karsdal, {Morten A}",

year = "2004",

doi = "10.1359/JBMR.040302",

language = "English",

volume = "19",

pages = "1144--53",

journal = "Journal of Bone and Mineral Research",

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TY - JOUR

T1 - The chloride channel inhibitor NS3736 [corrected] prevents bone resorption in ovariectomized rats without changing bone formation

AU - Schaller, Sophie

AU - Henriksen, Kim Steen

AU - Sveigaard, Christina

AU - Heegaard, Anne-Marie

AU - Hélix, Nathalie

AU - Stahlhut, Martin

AU - Ovejero, Maria C

AU - Johansen, Jens V

AU - Solberg, Helene

AU - Andersen, Thomas L

AU - Hougaard, Dorit

AU - Berryman, Mark

AU - Shiødt, Christine B

AU - Sørensen, Tobias Bjørn

AU - Lichtenberg, Jens

AU - Christophersen, Palle

AU - Foged, Niels

AU - Delaissé, Jean-Marie

AU - Engsig, Michael T

AU - Karsdal, Morten A

PY - 2004

Y1 - 2004

N2 - Chloride channel activity is essential for osteoclast function. Consequently, inhibition of the osteoclastic chloride channel should prevent bone resorption. Accordingly, we tested a chloride channel inhibitor on bone turnover and found that it inhibits bone resorption without affecting bone formation. This study indicates that chloride channel inhibitors are highly promising for treatment of osteoporosis.

AB - Chloride channel activity is essential for osteoclast function. Consequently, inhibition of the osteoclastic chloride channel should prevent bone resorption. Accordingly, we tested a chloride channel inhibitor on bone turnover and found that it inhibits bone resorption without affecting bone formation. This study indicates that chloride channel inhibitors are highly promising for treatment of osteoporosis.

KW - Animals

KW - Bone Resorption

KW - Cells, Cultured

KW - Chloride Channels

KW - Coated Pits, Cell-Membrane

KW - Female

KW - Gene Expression Profiling

KW - Humans

KW - Osteoclasts

KW - Osteogenesis

KW - Ovariectomy

KW - Rats

KW - Rats, Sprague-Dawley

KW - Tetrazoles

KW - Tissue Distribution

U2 - 10.1359/JBMR.040302

DO - 10.1359/JBMR.040302

M3 - Journal article

C2 - 15176998

SN - 0884-0431

VL - 19

SP - 1144

EP - 1153

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

IS - 7

ER -

The chloride channel inhibitor NS3736 [corrected] prevents bone resorption in ovariectomized rats without changing bone formation

Abstract

Keywords

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