Developmental biology of the pancreas Lab

Research output

Research output per year 1992 2012 2014 2015 2017 2018 2019

• 17 Journal article
• 5 Review
• 1 Letter

Research output per year

Research output per year

Search results

• 2019

  Mesodermal induction of pancreatic fate commitment

  Seymour, P. A. & Serup, P., Aug 2019, In: Seminars in Cell and Developmental Biology. 92, p. 77-88

  Research output: Contribution to journal › Review › peer-review

  • Endocrine Cells 100%
  • Cues 71%
  • Gastrula 58%
  • Endoderm 52%
  • Fibroblast Growth Factors 49%
  3 Citations (Scopus)
• 2018

  Dll1 and Jag1 are differentially required to specify proximal and distal pancreatic duct compartments.

  Seymour, P. A., Collin, C. A., Jorgensen, M. C., Imayoshi, I., Kageyama, R. & Serup, P., 2018, (E-pub ahead of print) In: bioRxiv, Developmental Biology. p. 1-36 36 p.

  Research output: Contribution to journal › Journal article › Research

  • Pancreatic Ducts 100%
  • Epithelium 33%
  • Ligands 30%
  • Drive 22%
  • Mental Competency 20%

• Inhibition of Cdk5 Promotes β-Cell Differentiation From Ductal Progenitors

  Liu, K-C., Leuckx, G., Sakano, D., Seymour, P. A., Mattsson, C. L., Rautio, L., Staels, W., Verdonck, Y., Serup, P., Kume, S., Heimberg, H. & Andersson, O., 1 Jan 2018, In: Diabetes. 67, 1, p. 58-70 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Cell Differentiation 100%
  • Zebrafish 93%
  • Roscovitine 47%
  • Endocrine Cells 37%
  • Induced Pluripotent Stem Cells 34%
  18 Citations (Scopus)

• Mechanosignalling via integrins directs fate decisions of pancreatic progenitors

  Mamidi, A., Prawiro, C., Seymour, P. A., de Lichtenberg, K. H., Jackson, A., Serup, P. & Semb, H., 6 Dec 2018, In: Nature. 564, 7734, p. 114-118 5 p.

  Research output: Contribution to journal › Letter › peer-review

  • Integrins 100%
  • Human Embryonic Stem Cells 85%
  • Pancreas 60%
  • Extracellular Matrix 59%
  • Single-Cell Analysis 47%
  66 Citations (Scopus)

• Neurog3-dependent pancreas dysgenesis causes ectopic pancreas in Hes1 mutant mice

  Jørgensen, M. C., de Lichtenberg, K. H., Collin, C. A., Klinck, R., Ekberg, J. H., Engelstoft, M. S., Lickert, H. & Serup, P., Sept 2018, In: Development (Cambridge, England). 145, 17, p. 1-11 11 p., dev163568.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Pancreas 100%
  • Morphogenesis 50%
  • Embryonic Structures 27%
  • Choristoma 21%
  • Phenotype 20%
  9 Citations (Scopus)

• Notch controls multiple pancreatic cell fate regulators through direct hes1-mediated repression.

  de Lichtenberg, K. H., Seymour, P. A., Joergensen, M. C., Kim, Y-H., Grapin-Botton, A., Magnuson, M. A., Nakic, N., Ferrer, J. & Serup, P., 2018, (E-pub ahead of print) In: bioRxiv, Developmental Biology. p. 1-30 30 p.

  Research output: Contribution to journal › Journal article › Research

  • Genes 100%
  • Chromatin Immunoprecipitation Sequencing 71%
  • Pancreas 70%
  • Amyloid Precursor Protein Secretases 34%
  • Gene Regulatory Networks 30%
• 2017

  Anteroposterior polarity and elongation in the absence of extraembryonic tissues and of spatially localised signalling in gastruloids: Mammalian embryonic organoids

  Turner, D. A., Girgin, M., Alonso-Crisostomo, L., Trivedi, V., Baillie-Johnson, P., Glodowski, C. R., Hayward, P. C., Collignon, J., Gustavsen, C., Serup, P., Steventon, B., Lutolf, M. P. & Arias, A. M., Nov 2017, In: Development (Cambridge). 144, 21, p. 3894-3906 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Brachyury protein 100%
  • Organoids 84%
  • Embryonic Structures 53%
  • Mammalian Embryo 32%
  • Gastrulation 27%
  74 Citations (Scopus)

  45 Downloads (Pure)

• Parsing the Pancreas

  Grapin-Botton, A. & Serup, P., 2 Mar 2017, In: New England Journal of Medicine. 376, 9, p. 886-888 3 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  3 Citations (Scopus)

• Properties of embryoid bodies

  Brickman, J. M. & Serup, P., 1 Mar 2017, In: Developmental Biology. 6, 2, 11 p., e259.

  Research output: Contribution to journal › Review › peer-review

  • Embryoid Bodies 100%
  • Embryonal Carcinoma Stem Cells 11%
  • Endoderm 10%
  • Mouse Embryonic Stem Cells 10%
  • Pluripotent Stem Cells 9%
  33 Citations (Scopus)
• 2016

  Research Resource: A Dual Proteomic Approach Identifies Regulated Islet Proteins During β-Cell Mass Expansion In Vivo

  Horn, S., Kirkegaard, J. S., Hoelper, S., Seymour, P. A., Rescan, C., Nielsen, J. H., Madsen, O. D., Jensen, J. N., Kruger, M., Gronborg, M. & Ahnfelt-Rønne, J., Jan 2016, In: Molecular endocrinology (Baltimore, Md.). 30, 1, p. 133-143 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Proteomics 100%
  • Pregnancy 65%
  • Proteins 40%
  • Hepatocyte Nuclear Factor 4 22%
  • Isotope Labeling 19%
  17 Citations (Scopus)
• 2015

  A conserved role for Notch in priming the cellular response to Shh through ciliary localisation of the key Shh transducer, Smoothened

  Stasiulewicz, M., Gray, S., Mastromina, I., Silva, J. C., Bjorklund, M., Seymour, P. A., Booth, D., Thompson, C., Green, R., Hall, E. A., Serup, P. & Dale, J. K., 1 Jul 2015, In: Development. 142, p. 2291-2303 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hedgehog Proteins 100%
  • Transducers 80%
  • Cilia 30%
  • Neuroepithelial Cells 19%
  • Notochord 18%
  48 Citations (Scopus)

• A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells

  Shih, H. P., Seymour, P. A., Patel, N. A., Xie, R., Wang, A., Liu, P. P., Yeo, G. W., Magnuson, M. A. & Sander, M., 13 Oct 2015, In: Cell Reports. 13, 2, p. 326-36 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Inducer 100%
  • Gene Regulatory Networks 93%
  • Stem Cells 63%
  • Endoderm 54%
  • Regulator Genes 44%
  39 Citations (Scopus)

• Pairing-up SOX to kick-start beta cell genesis

  Grapin-Botton, A., Seymour, P. A. & Gradwohl, G., 1 May 2015, In: Diabetologia. 58, 5, p. 859-861 3 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • SOX9 Transcription Factor 100%
  • Endocrine Cells 68%
  • Pluripotent Stem Cells 65%
  • Pancreas 48%
  • Cell Differentiation 45%
  2 Citations (Scopus)
• 2014

  Prdm5 suppresses Apc(Min)-driven intestinal adenomas and regulates monoacylglycerol lipase expression

  Galli, G. G., Multhaupt, H. A., Carrara, M., Honnens de Lichtenberg, K., Christensen, I. B. J., Linnemann, D., Santoni-Rugiu, E., Calogero, R. A. & Lund, A. H., 19 Jun 2014, In: Oncogene.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Monoacylglycerol Lipases 100%
  • Adenoma 59%
  • Chromatin Immunoprecipitation 46%
  • Carcinogenesis 32%
  • Gastrointestinal Neoplasms 25%
  18 Citations (Scopus)

• Sox9: a master regulator of the pancreatic program

  Seymour, P. A., 2014, In: The Review of Diabetic Studies. 11, 1, p. 51-83 33 p.

  Research output: Contribution to journal › Review › peer-review

  • Pancreas 100%
  • Campomelic Dysplasia 67%
  • Transcription Factors 58%
  • Haploinsufficiency 49%
  • Morphogenesis 39%
  44 Citations (Scopus)

• The Prdm13 histone methyltransferase encoding gene is a Ptf1a-Rbpj downstream target that suppresses glutamatergic and promotes GABAergic neuronal fate in the dorsal neural tube

  Hanotel, J., Bessodes, N., Thélie, A., Hedderich, M., Parain, K., Driessche, B. V., Brandão, K. D. O., Kricha, S., Jorgensen, M. C., Grapin-Botton, A., Serup, P., Lint, C. V., Perron, M., Pieler, T., Henningfeld, K. A. & Bellefroid, E. J., 15 Feb 2014, In: Developmental Biology. 386, 2, p. 340–357 18 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Histone Methyltransferases 100%
  • Neural Tube 90%
  • Xenopus 77%
  • Vertebrates 65%
  • Embryonic Structures 59%
  28 Citations (Scopus)
• 2013

  Bulking up on beta cells

  Seymour, P. A. & Serup, P., 22 Aug 2013, In: Briefings from the New England Journal of Medicine (Spanish Edition). 369, 8, p. 777-9 3 p.

  Research output: Contribution to journal › Review › peer-review

  8 Citations (Scopus)
• 2012

  A Functional Assay for Putative Mouse and Human Definitive Endoderm using Chick Whole-Embryo Cultures

  Johannesson, M., Semb, T. H., Serup, P. & Hansson, M., 21 Sept 2012, In: Stem Cell Research & Therapy. 2, 128, p. 2-7 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Endoderm 100%
  • Chick Embryo 92%
  • Protein 32%
  • Embryonic Stem Cells 24%
  • Mouse Embryonic Stem Cells 17%

• Mind bomb 1 is required for pancreatic ß-cell formation

  Horn, S., Kobberup, S., Jørgensen, M. C., Kalisz, M., Klein, T., Kageyama, R., Gegg, M., Lickert, H., Lindner, J., Magnuson, M. A., Kong, Y-Y., Serup, P., Ahnfelt-Rønne, J. & Jensen, J. N., 8 May 2012, In: Proceedings of the National Academy of Sciences USA (PNAS). 109, 19, p. 7356-61 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Bombs 100%
  • Stem Cells 24%
  • Endocrine Cells 24%
  • Endoderm 8%
  • Acinar Cells 7%
  54 Citations (Scopus)

• Partial promoter substitutions generating transcriptional sentinels of diverse signaling pathways in embryonic stem cells and mice

  Serup, P., Gustavsen, C., Klein, T., Potter, L. A., Lin, R., Mullapudi, N., Wandzioch, E., Hines, A., Davis, A., Bruun, C., Engberg, N., Petersen, D. R., Peterslund, J. M. L., Macdonald, R. J., Grapin-Botton, A., Magnuson, M. A. & Zaret, K. S., 1 Nov 2012, In: Disease Models and Mechanisms. 5, 6, p. 956-66 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Activin A 100%
  • activin A 71%
  • Recombinases 69%
  • Retinoic Acid 67%
  • Mouse Embryonic Stem Cells 63%
  10 Citations (Scopus)

• Signaling pathways regulating murine pancreatic development

  Serup, P., 1 Aug 2012, In: Seminars in Cell and Developmental Biology. 23, 6, p. 663-72 10 p.

  Research output: Contribution to journal › Review › peer-review

  • Morphogenesis 100%
  • Pancreas 85%
  • Cell Differentiation 80%
  • Transcription Factors 74%
  • Growth 50%
  24 Citations (Scopus)
• 1996

  Induction of insulin and islet amyloid polypeptide production in pancreatic islet glucagonoma cells by insulin promoter factor 1

  Serup, P., Jensen, J., Andersen, F. G., Jørgensen, M. C., Blume, N., Holst, J. J. & Madsen, O. D., 20 Aug 1996, In: Proceedings of the National Academy of Sciences of the United States of America. 93, 17, p. 9015-20 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • pancreatic and duodenal homeobox 1 protein 100%
  • Glucagonoma 91%
  • Islet Amyloid Polypeptide 81%
  • Islets of Langerhans 58%
  • Insulin 39%
  129 Citations (Scopus)
• 1992

  Immature transformed rat islet beta-cells differentially express C-peptides derived from the genes coding for insulin I and II as well as a transfected human insulin gene

  Blume, N., Petersen, J. S., Andersen, L. C., Kofod, H., Dyrberg, T., Michelsen, B. K., Serup, P. & Madsen, O. D., Feb 1992, In: Molecular Endocrinology. 6, 2, p. 299-307 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • C-Peptide 100%
  • Islets of Langerhans 87%
  • Insulin 59%
  • peptide I 47%
  • Genes 35%
  20 Citations (Scopus)