The gut microbiota influence behavior in the subchronic PCP induced animal model of schizophrenia

Bettina Merete Pyndt Jørgensen; Paul Redrobe; Tina  Brønnum Pedersen; Ellika Marie Selfjord; Dennis Sandris Nielsen; Niels Plath; Axel Kornerup Hansen; Dorte Bratbo Sørensen

The gut microbiota influence behavior in the subchronic PCP induced animal model of schizophrenia

Bidragets oversatte titel: Tarmfloraens indflydelse på adfærd i den subkroniske PCP inducerede dyremodel for schizofreni

Bettina Merete Pyndt Jørgensen, Paul Redrobe, Tina Brønnum Pedersen, Ellika Marie Selfjord, Dennis Sandris Nielsen, Niels Plath, Axel Kornerup Hansen, Dorte Bratbo Sørensen

Food Microbiology, Gut Health, and Fermentation

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Abstract

The gut microbiota has major impact on the individual. Here we show that the gut microbiota influence behavior in the subchronic PCP induced animal model of schizophrenia. The gut microbiota were changed in the group treated subchronic with PCP, and restoration coincided with normalisation of memory performance in lister hooded rats. Furthermore the individual gut microbiota correlated to the individual behavior abserved in the tests conducted. In conclusion results show an influence of the gut microbiota on behavior in this model, and therefore it might be relavant to include the information from the gut in analyses of studies using this model in the future.

Bidragets oversatte titel	Tarmfloraens indflydelse på adfærd i den subkroniske PCP inducerede dyremodel for schizofreni
Originalsprog	Engelsk
Publikationsdato	2013
Status	Udgivet - 2013
Begivenhed	Neurodag 2013: Neurobiology in action - University of Copenhagen, Banquet Hall, Copenhagen, Danmark Varighed: 25 okt. 2013 → 25 okt. 2013

Seminar

Seminar	Neurodag 2013
Lokation	University of Copenhagen, Banquet Hall
Land/Område	Danmark
By	Copenhagen
Periode	25/10/2013 → 25/10/2013

Emneord

Det Samfundsvidenskabelige Fakultet
Schizophrenia
Gut microbiota
behavior
Animal Model

Adgang til dokumentet

The Gut Microbiota Influence Behavior in theForlagets udgivne version, 514 KB

Citationsformater

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abstract = "The gut microbiota has major impact on the individual. Here we show that the gut microbiota influence behavior in the subchronic PCP induced animal model of schizophrenia. The gut microbiota were changed in the group treated subchronic with PCP, and restoration coincided with normalisation of memory performance in lister hooded rats. Furthermore the individual gut microbiota correlated to the individual behavior abserved in the tests conducted. In conclusion results show an influence of the gut microbiota on behavior in this model, and therefore it might be relavant to include the information from the gut in analyses of studies using this model in the future.",

keywords = "Faculty of Social Sciences, Schizophrenia, Gut microbiota, behavior, Animal Model",

author = "J{\o}rgensen, {Bettina Merete Pyndt} and Paul Redrobe and {Br{\o}nnum Pedersen}, Tina and Selfjord, {Ellika Marie} and Nielsen, {Dennis Sandris} and Niels Plath and Hansen, {Axel Kornerup} and S{\o}rensen, {Dorte Bratbo}",

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T1 - The gut microbiota influence behavior in the subchronic PCP induced animal model of schizophrenia

AU - Jørgensen, Bettina Merete Pyndt

AU - Redrobe, Paul

AU - Brønnum Pedersen, Tina

AU - Selfjord, Ellika Marie

AU - Nielsen, Dennis Sandris

AU - Plath, Niels

AU - Hansen, Axel Kornerup

AU - Sørensen, Dorte Bratbo

PY - 2013

Y1 - 2013

N2 - The gut microbiota has major impact on the individual. Here we show that the gut microbiota influence behavior in the subchronic PCP induced animal model of schizophrenia. The gut microbiota were changed in the group treated subchronic with PCP, and restoration coincided with normalisation of memory performance in lister hooded rats. Furthermore the individual gut microbiota correlated to the individual behavior abserved in the tests conducted. In conclusion results show an influence of the gut microbiota on behavior in this model, and therefore it might be relavant to include the information from the gut in analyses of studies using this model in the future.

AB - The gut microbiota has major impact on the individual. Here we show that the gut microbiota influence behavior in the subchronic PCP induced animal model of schizophrenia. The gut microbiota were changed in the group treated subchronic with PCP, and restoration coincided with normalisation of memory performance in lister hooded rats. Furthermore the individual gut microbiota correlated to the individual behavior abserved in the tests conducted. In conclusion results show an influence of the gut microbiota on behavior in this model, and therefore it might be relavant to include the information from the gut in analyses of studies using this model in the future.

KW - Faculty of Social Sciences

KW - Schizophrenia

KW - Gut microbiota

KW - behavior

KW - Animal Model

M3 - Poster

T2 - Neurodag 2013

Y2 - 25 October 2013 through 25 October 2013

ER -