The gut microbiota influence behavior in the subchronic PCP induced animal model of schizophrenia

Bettina Merete Pyndt Jørgensen; Paul Redrobe; Tina  Brønnum Pedersen; Ellika Marie Selfjord; Dennis Sandris Nielsen; Niels Plath; Axel Kornerup Hansen; Dorte Bratbo Sørensen

The gut microbiota influence behavior in the subchronic PCP induced animal model of schizophrenia

Bettina Merete Pyndt Jørgensen, Paul Redrobe, Tina Brønnum Pedersen, Ellika Marie Selfjord, Dennis Sandris Nielsen, Niels Plath, Axel Kornerup Hansen, Dorte Bratbo Sørensen

Food Microbiology, Gut Health, and Fermentation

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Abstract

The gut microbiota has major impact on the individual. Here we show that the gut microbiota influence behavior in the subchronic PCP induced animal model of schizophrenia. The gut microbiota were changed in the group treated subchronic with PCP, and restoration coincided with normalisation of memory performance in lister hooded rats. Furthermore the individual gut microbiota correlated to the individual behavior abserved in the tests conducted. In conclusion results show an influence of the gut microbiota on behavior in this model, and therefore it might be relavant to include the information from the gut in analyses of studies using this model in the future.

Translated title of the contribution	Tarmfloraens indflydelse på adfærd i den subkroniske PCP inducerede dyremodel for schizofreni
Original language	English
Publication date	2013
Publication status	Published - 2013
Event	Neurodag 2013: Neurobiology in action - University of Copenhagen, Banquet Hall, Copenhagen, Denmark Duration: 25 Oct 2013 → 25 Oct 2013

Seminar

Seminar	Neurodag 2013
Location	University of Copenhagen, Banquet Hall
Country/Territory	Denmark
City	Copenhagen
Period	25/10/2013 → 25/10/2013

Keywords

Faculty of Social Sciences

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Cite this

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title = "The gut microbiota influence behavior in the subchronic PCP induced animal model of schizophrenia",

abstract = "The gut microbiota has major impact on the individual. Here we show that the gut microbiota influence behavior in the subchronic PCP induced animal model of schizophrenia. The gut microbiota were changed in the group treated subchronic with PCP, and restoration coincided with normalisation of memory performance in lister hooded rats. Furthermore the individual gut microbiota correlated to the individual behavior abserved in the tests conducted. In conclusion results show an influence of the gut microbiota on behavior in this model, and therefore it might be relavant to include the information from the gut in analyses of studies using this model in the future.",

keywords = "Faculty of Social Sciences, Schizophrenia, Gut microbiota, behavior, Animal Model",

author = "J{\o}rgensen, {Bettina Merete Pyndt} and Paul Redrobe and {Br{\o}nnum Pedersen}, Tina and Selfjord, {Ellika Marie} and Nielsen, {Dennis Sandris} and Niels Plath and Hansen, {Axel Kornerup} and S{\o}rensen, {Dorte Bratbo}",

year = "2013",

language = "English",

note = "Neurodag 2013 : Neurobiology in action ; Conference date: 25-10-2013 Through 25-10-2013",

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TY - CONF

T1 - The gut microbiota influence behavior in the subchronic PCP induced animal model of schizophrenia

AU - Jørgensen, Bettina Merete Pyndt

AU - Redrobe, Paul

AU - Brønnum Pedersen, Tina

AU - Selfjord, Ellika Marie

AU - Nielsen, Dennis Sandris

AU - Plath, Niels

AU - Hansen, Axel Kornerup

AU - Sørensen, Dorte Bratbo

PY - 2013

Y1 - 2013

N2 - The gut microbiota has major impact on the individual. Here we show that the gut microbiota influence behavior in the subchronic PCP induced animal model of schizophrenia. The gut microbiota were changed in the group treated subchronic with PCP, and restoration coincided with normalisation of memory performance in lister hooded rats. Furthermore the individual gut microbiota correlated to the individual behavior abserved in the tests conducted. In conclusion results show an influence of the gut microbiota on behavior in this model, and therefore it might be relavant to include the information from the gut in analyses of studies using this model in the future.

AB - The gut microbiota has major impact on the individual. Here we show that the gut microbiota influence behavior in the subchronic PCP induced animal model of schizophrenia. The gut microbiota were changed in the group treated subchronic with PCP, and restoration coincided with normalisation of memory performance in lister hooded rats. Furthermore the individual gut microbiota correlated to the individual behavior abserved in the tests conducted. In conclusion results show an influence of the gut microbiota on behavior in this model, and therefore it might be relavant to include the information from the gut in analyses of studies using this model in the future.

KW - Faculty of Social Sciences

KW - Schizophrenia

KW - Gut microbiota

KW - behavior

KW - Animal Model

M3 - Poster

T2 - Neurodag 2013

Y2 - 25 October 2013 through 25 October 2013

ER -