Abstract
STUDY OBJECTIVE: To determine the effect of dietary supplementation with n-3 polyunsaturated fatty acids (n-3 PUFA) on disease variables in patients with rheumatoid arthritis.
DESIGN: Multicenter, randomized, placebo controlled, double blind.
SETTING: Three Danish hospital Departments of Rheumatology.
PATIENTS: Fifty-one patients with active rheumatoid arthritis.
INTERVENTION: Random allocation to 12 weeks of treatment with either six n-3 PUFA capsules (3.6 g) or six capsules with fat composition as the average Danish diet.
MAIN RESULTS: Significant improvement of morning stiffness and joint tenderness. No significant effect on the four other assessed clinical parameters. No serious side effects.
CONCLUSIONS: Dietary supplementation with n-3 PUFA in patients with rheumatoid arthritis improved two out of six patient reported disease parameters. Further studies are needed to clarify the more precise role of n-3 PUFA in the treatment of rheumatoid arthritis.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | European Journal of Clinical Investigation |
| Vol/bind | 22 |
| Udgave nummer | 10 |
| Sider (fra-til) | 687-91 |
| Antal sider | 5 |
| ISSN | 0014-2972 |
| Status | Udgivet - okt. 1992 |