Abstract
STUDY OBJECTIVE: To determine the effect of dietary supplementation with n-3 polyunsaturated fatty acids (n-3 PUFA) on disease variables in patients with rheumatoid arthritis.
DESIGN: Multicenter, randomized, placebo controlled, double blind.
SETTING: Three Danish hospital Departments of Rheumatology.
PATIENTS: Fifty-one patients with active rheumatoid arthritis.
INTERVENTION: Random allocation to 12 weeks of treatment with either six n-3 PUFA capsules (3.6 g) or six capsules with fat composition as the average Danish diet.
MAIN RESULTS: Significant improvement of morning stiffness and joint tenderness. No significant effect on the four other assessed clinical parameters. No serious side effects.
CONCLUSIONS: Dietary supplementation with n-3 PUFA in patients with rheumatoid arthritis improved two out of six patient reported disease parameters. Further studies are needed to clarify the more precise role of n-3 PUFA in the treatment of rheumatoid arthritis.
| Original language | English |
|---|---|
| Journal | European Journal of Clinical Investigation |
| Volume | 22 |
| Issue number | 10 |
| Pages (from-to) | 687-91 |
| Number of pages | 5 |
| ISSN | 0014-2972 |
| Publication status | Published - Oct 1992 |
Keywords
- Adult
- Aged
- Arthritis, Rheumatoid
- C-Reactive Protein
- Double-Blind Method
- Fatty Acids, Omega-3
- Humans
- Middle Aged
- Peptide Fragments
- Procollagen
- Clinical Trial
- Journal Article
- Randomized Controlled Trial
- Research Support, Non-U.S. Gov't