TY - JOUR
T1 - New insights from a β-glucan human intervention study using NMR metabolomics
AU - Mikkelsen, Mette Skau
AU - Savorani, Francesco
AU - Rasmussen, Morten Arendt
AU - Jespersen, Birthe P Møller
AU - Kristensen, Mette Bredal
AU - Engelsen, Søren Balling
N1 - CURIS 2014 NEXS 383
PY - 2014/9
Y1 - 2014/9
N2 - This study investigates the plasma metabolic effectiveness from 3.3g mixed linkage barley or oat β-glucan fibre per day by 1H NMR spectroscopy on plasma samples and multivariate data analysis. Three large-scale extracted, equally sized but structurally different β-glucans were tested in a blinded randomised cross-over design using young healthy adults, where the β-glucans were compared to a non-fibre control during a 21day dietary intervention period. Subject variance was found to dominate the metabolomics data although the variations in subject age and BMI were very small. The second most influential variation was found to be due to gender as characteristic lipoprotein profiles were found for male and female samples. The 3.3g/day did not perturb the blood homeostasis in healthy adults as no systematic differences between 3-week β-glucan treatments and control were found. The present study constitutes the first metabolomic β-glucan human intervention study which proves complementary and confirmatory with respect to previous nutritional investigations evaluating traditional cardiovascular disease risk markers.
AB - This study investigates the plasma metabolic effectiveness from 3.3g mixed linkage barley or oat β-glucan fibre per day by 1H NMR spectroscopy on plasma samples and multivariate data analysis. Three large-scale extracted, equally sized but structurally different β-glucans were tested in a blinded randomised cross-over design using young healthy adults, where the β-glucans were compared to a non-fibre control during a 21day dietary intervention period. Subject variance was found to dominate the metabolomics data although the variations in subject age and BMI were very small. The second most influential variation was found to be due to gender as characteristic lipoprotein profiles were found for male and female samples. The 3.3g/day did not perturb the blood homeostasis in healthy adults as no systematic differences between 3-week β-glucan treatments and control were found. The present study constitutes the first metabolomic β-glucan human intervention study which proves complementary and confirmatory with respect to previous nutritional investigations evaluating traditional cardiovascular disease risk markers.
U2 - 10.1016/j.foodres.2014.01.026
DO - 10.1016/j.foodres.2014.01.026
M3 - Journal article
SN - 0963-9969
VL - 63
SP - 210
EP - 217
JO - Food Research International
JF - Food Research International
ER -
