Extracted oat and barley β-glucans do not affect cholesterol metabolism in young healthy adults

Sabine Ibrügger; Mette Bredal Kristensen; Malene Wibe Poulsen; Mette Skau Mikkelsen; Johnny Ejsing; Birthe P Møller Jespersen; Lars Ove Dragsted; Søren Balling Engelsen; Susanne Gjedsted Bügel

doi:10.3945/jn.112.173054

Extracted oat and barley β-glucans do not affect cholesterol metabolism in young healthy adults

Sabine Ibrügger, Mette Bredal Kristensen, Malene Wibe Poulsen, Mette Skau Mikkelsen, Johnny Ejsing, Birthe P Møller Jespersen, Lars Ove Dragsted, Søren Balling Engelsen, Susanne Gjedsted Bügel

26 Citationer (Scopus)

Abstract

β-Glucans are known to exhibit hypocholesterolemic effects. Increased intestinal viscosity is thought to be crucial for cholesterol lowering. It is suggested that concentration, molecular mass, and structure, including the ratio of (1/3) to (1/4) glucan bonds in the molecule, are of importance for β-glucan functionality. This study investigated the effects of 3 different β-glucan sources, incorporated into a beverage and yogurt, on blood lipids and fecal endpoints. Fourteen participants completed this randomized, crossover, single-blinded study with four 3-wk periods: control and 3.3 g/d oat, barley, and barley mutant β-glucans of similar molecular mass. Before and after each period, fasting and postprandial blood samples were drawn and 3-d fecal samples were collected. Treatment did not affect changes in total, LDL, and HDL cholesterol compared with control; however, consumption of 3.3 g/d of oat β-glucans for 3 wk resulted in greater decreases in total (-0.29±0.09mmol/L, P < 0.01), LDL (-0.23±0.07mmol/L, P < 0.01), and HDL (-0.05±0.03mmol/L, P < 0.05) cholesterol compared with baseline. Changes in LDL in the β-glucan treatments were not related to β-glucan structure (cellotriosyl:cellotetraosyl). Decreases in fasting triacylglycerol were substantially greater after oat β-glucan treatment compared with control (P = 0.03). Fecal dry and wet weight, stool frequency, fecal pH, and energy excretion were unaffected. The results do not fully support the hypocholesterolemic effects by differently structured oat and barley β-glucans. However, substantial differences compared with baseline suggest a potential for oat β-glucan, presumably due to its higher solubility and viscosity. This underlines the importance of elusive structural β-glucan features for beneficial physiologic effects.

Originalsprog	Engelsk
Tidsskrift	Journal of Nutrition
Vol/bind	143
Udgave nummer	10
Sider (fra-til)	1579-1585
Antal sider	7
ISSN	0022-3166
DOI	https://doi.org/10.3945/jn.112.173054
Status	Udgivet - 2013

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10.3945/jn.112.173054

https://academic.oup.com/jn/article-pdf/143/10/1579/23975635/1579.pdf

Citationsformater

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title = "Extracted oat and barley β-glucans do not affect cholesterol metabolism in young healthy adults",

abstract = "β-Glucans are known to exhibit hypocholesterolemic effects. Increased intestinal viscosity is thought to be crucial for cholesterol lowering. It is suggested that concentration, molecular mass, and structure, including the ratio of (1/3) to (1/4) glucan bonds in the molecule, are of importance for β-glucan functionality. This study investigated the effects of 3 different β-glucan sources, incorporated into a beverage and yogurt, on blood lipids and fecal endpoints. Fourteen participants completed this randomized, crossover, single-blinded study with four 3-wk periods: control and 3.3 g/d oat, barley, and barley mutant β-glucans of similar molecular mass. Before and after each period, fasting and postprandial blood samples were drawn and 3-d fecal samples were collected. Treatment did not affect changes in total, LDL, and HDL cholesterol compared with control; however, consumption of 3.3 g/d of oat β-glucans for 3 wk resulted in greater decreases in total (-0.29±0.09mmol/L, P < 0.01), LDL (-0.23±0.07mmol/L, P < 0.01), and HDL (-0.05±0.03mmol/L, P < 0.05) cholesterol compared with baseline. Changes in LDL in the β-glucan treatments were not related to β-glucan structure (cellotriosyl:cellotetraosyl). Decreases in fasting triacylglycerol were substantially greater after oat β-glucan treatment compared with control (P = 0.03). Fecal dry and wet weight, stool frequency, fecal pH, and energy excretion were unaffected. The results do not fully support the hypocholesterolemic effects by differently structured oat and barley β-glucans. However, substantial differences compared with baseline suggest a potential for oat β-glucan, presumably due to its higher solubility and viscosity. This underlines the importance of elusive structural β-glucan features for beneficial physiologic effects.",

author = "Sabine Ibr{\"u}gger and Kristensen, {Mette Bredal} and Poulsen, {Malene Wibe} and Mikkelsen, {Mette Skau} and Johnny Ejsing and Jespersen, {Birthe P M{\o}ller} and Dragsted, {Lars Ove} and Engelsen, {S{\o}ren Balling} and B{\"u}gel, {Susanne Gjedsted}",

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T1 - Extracted oat and barley β-glucans do not affect cholesterol metabolism in young healthy adults

AU - Ibrügger, Sabine

AU - Kristensen, Mette Bredal

AU - Poulsen, Malene Wibe

AU - Mikkelsen, Mette Skau

AU - Ejsing, Johnny

AU - Jespersen, Birthe P Møller

AU - Dragsted, Lars Ove

AU - Engelsen, Søren Balling

AU - Bügel, Susanne Gjedsted

N1 - CURIS 2013 NEXS 220

PY - 2013

Y1 - 2013

N2 - β-Glucans are known to exhibit hypocholesterolemic effects. Increased intestinal viscosity is thought to be crucial for cholesterol lowering. It is suggested that concentration, molecular mass, and structure, including the ratio of (1/3) to (1/4) glucan bonds in the molecule, are of importance for β-glucan functionality. This study investigated the effects of 3 different β-glucan sources, incorporated into a beverage and yogurt, on blood lipids and fecal endpoints. Fourteen participants completed this randomized, crossover, single-blinded study with four 3-wk periods: control and 3.3 g/d oat, barley, and barley mutant β-glucans of similar molecular mass. Before and after each period, fasting and postprandial blood samples were drawn and 3-d fecal samples were collected. Treatment did not affect changes in total, LDL, and HDL cholesterol compared with control; however, consumption of 3.3 g/d of oat β-glucans for 3 wk resulted in greater decreases in total (-0.29±0.09mmol/L, P < 0.01), LDL (-0.23±0.07mmol/L, P < 0.01), and HDL (-0.05±0.03mmol/L, P < 0.05) cholesterol compared with baseline. Changes in LDL in the β-glucan treatments were not related to β-glucan structure (cellotriosyl:cellotetraosyl). Decreases in fasting triacylglycerol were substantially greater after oat β-glucan treatment compared with control (P = 0.03). Fecal dry and wet weight, stool frequency, fecal pH, and energy excretion were unaffected. The results do not fully support the hypocholesterolemic effects by differently structured oat and barley β-glucans. However, substantial differences compared with baseline suggest a potential for oat β-glucan, presumably due to its higher solubility and viscosity. This underlines the importance of elusive structural β-glucan features for beneficial physiologic effects.

AB - β-Glucans are known to exhibit hypocholesterolemic effects. Increased intestinal viscosity is thought to be crucial for cholesterol lowering. It is suggested that concentration, molecular mass, and structure, including the ratio of (1/3) to (1/4) glucan bonds in the molecule, are of importance for β-glucan functionality. This study investigated the effects of 3 different β-glucan sources, incorporated into a beverage and yogurt, on blood lipids and fecal endpoints. Fourteen participants completed this randomized, crossover, single-blinded study with four 3-wk periods: control and 3.3 g/d oat, barley, and barley mutant β-glucans of similar molecular mass. Before and after each period, fasting and postprandial blood samples were drawn and 3-d fecal samples were collected. Treatment did not affect changes in total, LDL, and HDL cholesterol compared with control; however, consumption of 3.3 g/d of oat β-glucans for 3 wk resulted in greater decreases in total (-0.29±0.09mmol/L, P < 0.01), LDL (-0.23±0.07mmol/L, P < 0.01), and HDL (-0.05±0.03mmol/L, P < 0.05) cholesterol compared with baseline. Changes in LDL in the β-glucan treatments were not related to β-glucan structure (cellotriosyl:cellotetraosyl). Decreases in fasting triacylglycerol were substantially greater after oat β-glucan treatment compared with control (P = 0.03). Fecal dry and wet weight, stool frequency, fecal pH, and energy excretion were unaffected. The results do not fully support the hypocholesterolemic effects by differently structured oat and barley β-glucans. However, substantial differences compared with baseline suggest a potential for oat β-glucan, presumably due to its higher solubility and viscosity. This underlines the importance of elusive structural β-glucan features for beneficial physiologic effects.

U2 - 10.3945/jn.112.173054

DO - 10.3945/jn.112.173054

M3 - Journal article

C2 - 23946347

SN - 0022-3166

VL - 143

SP - 1579

EP - 1585

JO - Journal of Nutrition

JF - Journal of Nutrition

IS - 10

ER -

Extracted oat and barley β-glucans do not affect cholesterol metabolism in young healthy adults

Abstract

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