Crystallization and preliminary X-ray analysis of a PNA-DNA complex

TY - JOUR

T1 - Crystallization and preliminary X-ray analysis of a PNA-DNA complex

AU - Kastrup, J S

AU - Pilgaard, M

AU - Nielsen, Peter E.

PY - 1995/4/17

Y1 - 1995/4/17

N2 - Peptide nucleic acids (PNAs) are DNA mimics with a peptide backbone. PNAs are being intensely investigated owing to a potential as gene-targeted drugs. A PNA (H-GTAGATCACT-NH2)-DNA (5'-AGTGATCTAC-3') complex has been crystallized in a tetragonal space group P4(1)22 with cell dimensions a = b = 79.8, c = 99.9 angstrum. The crystals diffract to about 5 angstrum resolution.

AB - Peptide nucleic acids (PNAs) are DNA mimics with a peptide backbone. PNAs are being intensely investigated owing to a potential as gene-targeted drugs. A PNA (H-GTAGATCACT-NH2)-DNA (5'-AGTGATCTAC-3') complex has been crystallized in a tetragonal space group P4(1)22 with cell dimensions a = b = 79.8, c = 99.9 angstrum. The crystals diffract to about 5 angstrum resolution.

KW - Base Sequence

KW - Crystallization

KW - Crystallography, X-Ray

KW - DNA/chemistry

KW - Molecular Sequence Data

KW - Oligodeoxyribonucleotides/chemistry

M3 - Journal article

C2 - 7729531

SN - 0014-5793

VL - 363

SP - 115

EP - 117

JO - FEBS Letters

JF - FEBS Letters

IS - 1-2

ER -