Crystallization and preliminary X-ray analysis of a PNA-DNA complex

J S Kastrup; M Pilgaard; Peter E. Nielsen

Crystallization and preliminary X-ray analysis of a PNA-DNA complex

J S Kastrup, M Pilgaard, Peter E. Nielsen

Transcription, RNA, and Gene Medicine Program

Abstract

Peptide nucleic acids (PNAs) are DNA mimics with a peptide backbone. PNAs are being intensely investigated owing to a potential as gene-targeted drugs. A PNA (H-GTAGATCACT-NH2)-DNA (5'-AGTGATCTAC-3') complex has been crystallized in a tetragonal space group P4(1)22 with cell dimensions a = b = 79.8, c = 99.9 angstrum. The crystals diffract to about 5 angstrum resolution.

Originalsprog	Engelsk
Tidsskrift	FEBS Letters
Vol/bind	363
Udgave nummer	1-2
Sider (fra-til)	115-7
Antal sider	3
ISSN	0014-5793
Status	Udgivet - 17 apr. 1995

Citationsformater

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title = "Crystallization and preliminary X-ray analysis of a PNA-DNA complex",

abstract = "Peptide nucleic acids (PNAs) are DNA mimics with a peptide backbone. PNAs are being intensely investigated owing to a potential as gene-targeted drugs. A PNA (H-GTAGATCACT-NH2)-DNA (5'-AGTGATCTAC-3') complex has been crystallized in a tetragonal space group P4(1)22 with cell dimensions a = b = 79.8, c = 99.9 angstrum. The crystals diffract to about 5 angstrum resolution.",

keywords = "Base Sequence, Crystallization, Crystallography, X-Ray, DNA/chemistry, Molecular Sequence Data, Oligodeoxyribonucleotides/chemistry",

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T1 - Crystallization and preliminary X-ray analysis of a PNA-DNA complex

AU - Kastrup, J S

AU - Pilgaard, M

AU - Nielsen, Peter E.

PY - 1995/4/17

Y1 - 1995/4/17

N2 - Peptide nucleic acids (PNAs) are DNA mimics with a peptide backbone. PNAs are being intensely investigated owing to a potential as gene-targeted drugs. A PNA (H-GTAGATCACT-NH2)-DNA (5'-AGTGATCTAC-3') complex has been crystallized in a tetragonal space group P4(1)22 with cell dimensions a = b = 79.8, c = 99.9 angstrum. The crystals diffract to about 5 angstrum resolution.

AB - Peptide nucleic acids (PNAs) are DNA mimics with a peptide backbone. PNAs are being intensely investigated owing to a potential as gene-targeted drugs. A PNA (H-GTAGATCACT-NH2)-DNA (5'-AGTGATCTAC-3') complex has been crystallized in a tetragonal space group P4(1)22 with cell dimensions a = b = 79.8, c = 99.9 angstrum. The crystals diffract to about 5 angstrum resolution.

KW - Base Sequence

KW - Crystallization

KW - Crystallography, X-Ray

KW - DNA/chemistry

KW - Molecular Sequence Data

KW - Oligodeoxyribonucleotides/chemistry

M3 - Journal article

C2 - 7729531

SN - 0014-5793

VL - 363

SP - 115

EP - 117

JO - F E B S Letters

JF - F E B S Letters

IS - 1-2

ER -

Crystallization and preliminary X-ray analysis of a PNA-DNA complex

Abstract

Fingeraftryk

Citationsformater