Publikationer pr. år
Publikationer pr. år
Personlig profil
Primære forskningsområder
The research interests are centered around the DNA mimic PNA (peptide nucleic acid), and the chemical biology and medicinal chemistry properties and applications of derivatives of this molecule. This includes drug discovery (antisense antibiotics, muscular dystrophy, cystic fibrosis), gene targeting and antisense principles in general and cellular and in vivo delivery and administration of biopharmaceuticals. Additional interests cover origin of life prebiotic systems and the effects of oxidative stress on cellular RNA.
Aktuel forskning
- Discovery of PNA and peptide based antibiotics against resistant Gram-negative bacterial infections
- Quorum sensing inhibitors as cystic fibrosis drugs
- Antisense drugs for Duchenne muscular dystrophy
- Antisense drug delivery and in vivo administration
Emneord
- Det Sundhedsvidenskabelige Fakultet
- Gene targeting
- PNA
- RNA interference
- Drug delivery
Fingeraftryk
Dyk ned i forskningsemnerne, hvor Peter E. Nielsen er aktive. Disse emneetiketter kommer fra dennes persons arbejder. Sammen danner de et unikt fingerprint.
- 6 Lignende profiler
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Cooperative Cellular Uptake and Activity of Octaarginine Antisense Peptide Nucleic acid (PNA) Conjugates
Ghavami, M., Shiraishi, T. & Nielsen, P. E., okt. 2019, I: Biomolecules. 9, 10, 554.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Downregulation of TdT Expression through Splicing Modulation by Antisense Peptide Nucleic Acid (PNA)
Montazersaheb, S., Kazemi, M., Nabat, E., Nielsen, P. E. & Hejazi, M. S., 2019, I: Current Pharmaceutical Biotechnology. 20, 2, s. 168-178 11 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Microwave-assisted solid-phase synthesis of antisense acpP peptide nucleic acid-peptide conjugates active against colistin- and tigecycline-resistant E. coli and K. pneumoniae
Hansen, A. M., Bonke, G., Hogendorf, W. F. J., Björkling, F., Nielsen, J., Kongstad, K. T., Zabicka, D., Tomczak, M., Urbas, M., Nielsen, P. E. & Franzyk, H., 15 apr. 2019, I: European Journal of Medicinal Chemistry. 168, s. 134-145 12 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Optimization of lung infection model with carbapenemase producing Klebsiella pneumoniae ST258 (KPC-2) for intranasal treatment in neutropenic NMRI mice
Goncalves Cavaco, L. M., Hjortkjær, C. B., Rasmussen, C., Nielsen, P. E. & Lundberg, C. V., 17 apr. 2019.Publikation: Konferencebidrag › Poster › Forskning › peer review
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PNA length restriction of antibacterial activity of peptide-PNA conjugates in Escherichia coli through effects of the inner membrane
Goltermann, L., Yavari, N., Zhang, M., Ghosal, A. & Nielsen, P. E., 2019, I: Frontiers in Microbiology. 10, MAY, 8 s., 1032.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Effective photo-enhancement of cellular activity of fluorophore-octaarginine antisense PNA conjugates correlates with singlet oxygen formation, endosomal escape and chromophore lipophilicity
Yarani, R., Shiraishi, T. & Nielsen, P. E., 1 dec. 2018, I: Scientific Reports. 8, 11 s., 638.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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An antisense peptide nucleic acid against Pseudomonas aeruginosa inhibiting bacterial-induced inflammatory responses in the cystic fibrosis IB3-1 cellular model system
Montagner, G., Bezzerri, V., Cabrini, G., Fabbri, E., Borgatti, M., Lampronti, I., Finotti, A., Nielsen, P. E. & Gambari, R., 1 jun. 2017, I: International Journal of Biological Macromolecules. 99, s. 492-498 7 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Antisense PNA antibiotics against multiresistant Gram-negative bacteria
Nielsen, P. E., Björkling, F. & Franzyk, H., 2017, I: International Journal of Molecular Medicine. 40, Suppl. 1, s. S22 1 s., Abstract 169.Publikation: Bidrag til tidsskrift › Konferenceabstrakt i tidsskrift › Forskning
Aktiviteter
- 1 Redaktør af serie
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Humana Press - Springer Verlag (Forlag)
Nielsen, P. E. (Redaktør)
2014Aktivitet: Udgivelse af peer-review og redaktionelt arbejde - typer › Redaktør af serie › Forskning