Beyond genetics. Influence of dietary factors and gut microbiota on type 1 diabetes

TY - JOUR

T1 - Beyond genetics. Influence of dietary factors and gut microbiota on type 1 diabetes

AU - Nielsen, Dennis Sandris

AU - Krych, Lukasz

AU - Buschard, Karsten

AU - Hansen, Camilla Hartmann Friis

AU - Hansen, Axel Jacob Kornerup

N1 - Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

PY - 2014/11/17

Y1 - 2014/11/17

N2 - Type 1 diabetes (T1D) is an autoimmune disease ultimately leading to destruction of insulin secreting β-cells in the pancreas. Genetic susceptibility plays an important role in T1D etiology, but even mono-zygotic twins only have a concordance rate of around 50%, underlining that other factors than purely genetic are involved in disease development. Here we review the influence of dietary and environmental factors on T1D development in humans as well as animal models. Even though data are still inconclusive, there are strong indications that gut microbiota dysbiosis plays an important role in T1D development and evidence from animal models suggests that gut microbiota manipulation might prove valuable in future prevention of T1D in genetically susceptible individuals.

AB - Type 1 diabetes (T1D) is an autoimmune disease ultimately leading to destruction of insulin secreting β-cells in the pancreas. Genetic susceptibility plays an important role in T1D etiology, but even mono-zygotic twins only have a concordance rate of around 50%, underlining that other factors than purely genetic are involved in disease development. Here we review the influence of dietary and environmental factors on T1D development in humans as well as animal models. Even though data are still inconclusive, there are strong indications that gut microbiota dysbiosis plays an important role in T1D development and evidence from animal models suggests that gut microbiota manipulation might prove valuable in future prevention of T1D in genetically susceptible individuals.

U2 - 10.1016/j.febslet.2014.04.010

DO - 10.1016/j.febslet.2014.04.010

M3 - Journal article

C2 - 24746688

SN - 0014-5793

VL - 588

SP - 4234

EP - 4243

JO - FEBS Letters

JF - FEBS Letters

IS - 22

ER -